J Neurosurg Anesthesiol:岛叶切除对自主神经活动的影响

2015-08-30 张森 译 MedSci原创

岛叶(Insula)为大脑皮质的一部分,是向内凹陷的皮层区域,被包埋在外侧裂之内,无法直接从完整的脑的外部观察到;其与额叶,颞叶和顶叶的皮层相连通。此外,岛叶亦是中枢自主网络的基础结构,在自主神经对环境应激因素的反应中发挥着重要的作用。此前,研究人员主要就脑血管事件,对岛叶在人自主神经调节中的作用进行了探讨,但是由于缺乏脑血管事件前后时间相关进程的对照,使得对于这些发现的解释变得更加复杂。然而,通

岛叶(Insula)为大脑皮质的一部分,是向内凹陷的皮层区域,被包埋在外侧裂之内,无法直接从完整的脑的外部观察到;其与额叶颞叶顶叶的皮层相连通。此外,岛叶亦是中枢自主网络的基础结构,在自主神经对环境应激因素的反应中发挥着重要的作用。此前,研究人员主要就脑血管事件,对岛叶在人自主神经调节中的作用进行了探讨,但是由于缺乏脑血管事件前后时间相关进程的对照,使得对于这些发现的解释变得更加复杂。然而,通过手术将岛叶肿瘤切除,或许为自主神经失调和后续心律失常的神经回路提供了唯一的信息。

荷兰蒂尔堡大学的研究人员,分别通过左和右岛叶肿瘤切除两个案例(WHO分级Ⅱ级低级星形细胞瘤)对自主神经调节的作用进行检测。同时,对患者肿瘤切除术前及术中的心率变异率和心律失常的变化进行监测。

结果显示,右岛叶肿瘤切除将导致患者心率缓慢,并进一步显著增强副交感神经的活动。而左岛叶切除并没有改变自主神经的活动。

 

此项研究表明,右岛叶在副交感神经自主调节及后续心律失常中发挥着重要作用。左和右岛叶切除,对于自主神经失调和不良的脑-心相互作用的长期作用仍需要进一步的研究来探讨,尤其是对存在心律失常风险的患者。

原始出处:

de Morree HM, Rutten GJ, et al.Effects of Insula Resection on Autonomic Nervous System Activity.J Neurosurg Anesthesiol. 2015 Jul 16.

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    2016-09-15 1e10c84am36(暂无匿称)

    文章不错,值得拜读

    0

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    2015-12-26 hixiaoluo

    值得看,好好收藏,谢谢分享

    0

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    2015-09-01 lsndxfj
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    2015-09-01 skhzy