Protein & Cell:中科院发现,SIRT7作为异染色质稳定剂,拮抗人类干细胞衰老。

2020-06-07 MedSci原创 MedSci原创

SIRT7作为与衰老和疾病有关的sirtuin家族成员,是新陈代谢和压力反应的调节器。至今为止,我们仍然不清楚人类成体干细胞群体如何受到SIRT7的影响。

SIRT7作为与衰老和疾病有关的sirtuin家族成员,是新陈代谢和压力反应的调节器。至今为止,我们仍然不清楚人类成体干细胞群体如何受到SIRT7的影响。

最近,中科院曲静、刘光慧、宋默识以及张维绮课题组合作发现,SIRT7的表达在人类间充质干细胞(hMSC)衰老过程中下降,SIRT7的缺失会加速衰老。

在机制上说,SIRT7与核层蛋白和异染色质蛋白形成复合物,从而维持异染色质在核外周的抑制状态。相应地,SIRT7的缺失会导致异染色质的丢失,LINE1逆转录子(LINE1)的去抑制,并通过cGAS-STING通路激活先天免疫信号。

这些与衰老相关的细胞缺陷可通过异染色质蛋白的过度表达或用LINE1靶向逆转录酶抑制剂处理来逆转。

这些研究结果共同凸显了SIRT7保障染色质结构的原理,以控制先天免疫调节,并提供干细胞老化期间的保护。

 

原始出处:

Shijia Bi et al. SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer, Protein & Cell (2020). 

 

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    2021-11-12 湘雅科教

    已拜读,受益匪浅。

    0

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    2020-08-23 维他命
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createdTime=Mon Jan 11 09:29:23 CST 2021, time=2021-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025463, encodeId=43ff10254636a, content=干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Wed Jun 10 10:29:23 CST 2020, time=2020-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337119, encodeId=da11133e11990, content=<a href='/topic/show?id=715ae8023ea' target=_blank style='color:#2F92EE;'>#细胞衰老#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78023, encryptionId=715ae8023ea, topicName=细胞衰老)], attachment=null, authenticateStatus=null, 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style='color:#2F92EE;'>#染色质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61842, encryptionId=dc0e6184243, topicName=染色质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d4ac16256960, createdName=guozhenyu, createdTime=Tue Jun 09 01:29:23 CST 2020, time=2020-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602273, encodeId=11bc16022e316, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Tue Jun 09 01:29:23 CST 2020, time=2020-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605211, encodeId=0cb716052110b, content=<a href='/topic/show?id=d88814e5699' target=_blank style='color:#2F92EE;'>#protein#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14756, encryptionId=d88814e5699, topicName=protein)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a45319348704, createdName=江川靖瑶, createdTime=Tue Jun 09 01:29:23 CST 2020, time=2020-06-09, status=1, ipAttribution=)]
    2021-01-11 gous
  5. 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style='color:#2F92EE;'>#染色质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61842, encryptionId=dc0e6184243, topicName=染色质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d4ac16256960, createdName=guozhenyu, createdTime=Tue Jun 09 01:29:23 CST 2020, time=2020-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602273, encodeId=11bc16022e316, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Tue Jun 09 01:29:23 CST 2020, time=2020-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605211, encodeId=0cb716052110b, content=<a href='/topic/show?id=d88814e5699' target=_blank style='color:#2F92EE;'>#protein#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14756, encryptionId=d88814e5699, topicName=protein)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a45319348704, createdName=江川靖瑶, createdTime=Tue Jun 09 01:29:23 CST 2020, time=2020-06-09, status=1, ipAttribution=)]
    2020-06-10 独孤立克

    干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦

    0

  6. 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  7. 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  8. 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  9. 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    2020-06-09 sunylz
  10. 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