Circulation:运动和减肥对肥胖的老年人的主动脉僵硬度的保护作用

2021-09-06 Nebula MedSci原创

对于肥胖的老年人,有氧运动与适度的热量限制相结合,比单纯运动更能改善近端主动脉僵硬度

肥胖可能会加速与年龄相关的主动脉僵硬度进展。虽然有氧运动训练对主动脉结构和功能都有良好的影响,但单纯运动可能不足以改善肥胖老年人的主动脉僵硬度。本研究旨在确定有氧运动训练±中高热量限制(CR)对 160 名(65-79 岁)肥胖(体重指数[BMI] 30-45 kg/m2)老年人的近端主动脉结构和功能的影响

受试者被随机分至三组:纯有氧运动训练组(第1组,跑步机 30 min,4天/周,心率储备 65-70%,n=56),有氧运动训练+CR组(第2组,n=55)和有氧运动训练+更高强度CR组(第3组,n=49),持续干预20周。通过血管磁共振成像评估主动脉脉搏波速度、主动脉扩张性,以及主动脉结构和功能等指标。

三组动脉僵硬度和张力的变化

与纯有氧运动训练组(-1.66 kg [95% CI -2.94~-0.38])相比,有氧运动训练+CR组(-8.0 kg [-9.17~-6.87])和有氧运动训练+更高强度CR组(-8.98 kg [-10.23~-7.73)的体重减少均更显著(p<0.017)。

有氧运动训练+中度CR对降主动脉扩张能力(p=0.008)、张力(p=0.004)和主动脉弓脉波速度(p=0.01)均有显著治疗效果,扩张能力提高了21% (p=0.016),脉波速度降低了8% (p=0.058)。 但在纯有氧运动训练组和有氧运动训练+更高强度CR组,主动脉僵硬度指标、主动脉结构和功能的其他指标均无显著变化。

总体而言,主动脉扩张性的增加与体重和体脂分布改善相关,但经对多重对比调整后,这些相关性的显著性消失。综上,对于肥胖的老年人,有氧运动与适度的CR相结合,比单纯运动更能改善近端主动脉僵硬度

原始出处:

Tina E. Brinkley, et al. Effects of Exercise and Weight Loss on Proximal Aortic Stiffness in Older Adults With Obesity. Circulation. 2021;144:684–693

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  5. 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=858f5514421, createdName=ms3000000726440470, createdTime=Tue Sep 07 00:07:25 CST 2021, time=2021-09-07, status=1, ipAttribution=)]
  6. 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=858f5514421, createdName=ms3000000726440470, createdTime=Tue Sep 07 00:07:25 CST 2021, time=2021-09-07, status=1, ipAttribution=)]
    2021-09-07 ms4000001011140431

    学习了

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=858f5514421, createdName=ms3000000726440470, createdTime=Tue Sep 07 00:07:25 CST 2021, time=2021-09-07, status=1, ipAttribution=)]
    2021-09-07 查查佳佳

    咯俄语课

    0

  8. 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encodeId=05ff10152e363, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45db5439244, createdName=ms4000001011140431, createdTime=Tue Sep 07 09:01:43 CST 2021, time=2021-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1015262, encodeId=64ce1015262ae, content=咯俄语课, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Tue Sep 07 08:57:52 CST 2021, time=2021-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1015251, encodeId=191c101525168, content=很好的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e3a5419766, createdName=ms6000000800992147, createdTime=Tue Sep 07 08:02:04 CST 2021, time=2021-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048400, encodeId=81d8104840020, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Tue Sep 07 00:11:32 CST 2021, time=2021-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1015208, encodeId=712f10152087c, content=棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=858f5514421, createdName=ms3000000726440470, createdTime=Tue Sep 07 00:07:25 CST 2021, time=2021-09-07, status=1, ipAttribution=)]
    2021-09-07 ms6000000800992147

    很好的研究

    0

  9. 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content=很好的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e3a5419766, createdName=ms6000000800992147, createdTime=Tue Sep 07 08:02:04 CST 2021, time=2021-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048400, encodeId=81d8104840020, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Tue Sep 07 00:11:32 CST 2021, time=2021-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1015208, encodeId=712f10152087c, content=棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=858f5514421, createdName=ms3000000726440470, createdTime=Tue Sep 07 00:07:25 CST 2021, time=2021-09-07, status=1, ipAttribution=)]
    2021-09-07 CHANGE

    什么时候有懒人用的减肥神药?

    0

  10. 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content=很好的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e3a5419766, createdName=ms6000000800992147, createdTime=Tue Sep 07 08:02:04 CST 2021, time=2021-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048400, encodeId=81d8104840020, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Tue Sep 07 00:11:32 CST 2021, time=2021-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1015208, encodeId=712f10152087c, content=棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=858f5514421, createdName=ms3000000726440470, createdTime=Tue Sep 07 00:07:25 CST 2021, time=2021-09-07, status=1, ipAttribution=)]
    2021-09-07 ms3000000726440470

    0

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