JAHA:糖尿病与青年和中年卒中幸存者的住院和长期预后不良相关

2021-07-04 MedSci原创 MedSci原创

对于65岁以下既往有糖尿病的卒中患者长期预后不佳的问题可能需要重点进行二级预防和危险因素管理。

在18至64岁的成年人中,缺血性卒中的发病率有所增加,但对特定危险因素与结局之间的关系知之甚少。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在调查65岁以下伴有糖尿病的卒中患者院内和长期结局。

2003年至2013年间,研究人员纳入了来自安大略省综合性卒中中心连续就诊年龄小于65岁的急性缺血性卒中患者。多项Lgositic回归用于估计住院死亡率或直接出院至长期或持续护理的调整比值比(OR[95%CI])。Cox比例风险回归用于估计长期死亡率、卒中/短暂性脑缺血发作再入院、长期护理入院和痴呆事件的调整风险比(aHR[95%CI])。预先定义的敏感性分析用于评估年轻(18-49岁)和中年(50-65岁)亚组的卒中结局。

在8293名卒中幸存者(平均年龄为53.6±8.9岁)中,既往伴有糖尿病与院内死亡(调整后的OR为1.46[95%CI为1.14-1.87])或直接出院至长期治疗的可能性更高(调整后的OR为1.65[95%CI为1.07-2.54])。出院的卒中幸存者(N=7847)中位随访6.3年期间,既往有糖尿病与死亡(aHR为1.68[95%CI为1.50-1.88])、接受长期护理(aHR为1.57[95%CI为1.35-1.82])、卒中/短暂性脑缺血发作再入院(aHR为1.37[95%CI为0.21-1.54])和痴呆事件(aHR为1.44[95%CI为1.17]-1.77])风险增加相关。只有年轻卒中幸存者的痴呆事件没有增加。

由此可见,对于65岁以下既往有糖尿病的卒中患者长期预后不佳的问题可能需要重点进行二级预防和危险因素管理

原始出处:

Bradley J. MacIntosh.et al.Diabetes Mellitus Is Associated With Poor In‐Hospital and Long‐Term Outcomes in Young and Midlife Stroke Survivors.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.019991

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    2021-07-06 zhaohui6731
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  5. [GetPortalCommentsPageByObjectIdResponse(id=2018371, encodeId=134120183e122, content=<a href='/topic/show?id=5cac36039a1' target=_blank style='color:#2F92EE;'>#卒中幸存者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36039, encryptionId=5cac36039a1, topicName=卒中幸存者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6393434, createdName=ailian1202, createdTime=Sun May 01 13:31:42 CST 2022, time=2022-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645651, encodeId=a815164565139, content=<a href='/topic/show?id=79d99e04630' target=_blank style='color:#2F92EE;'>#长期预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97046, encryptionId=79d99e04630, topicName=长期预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e4823226485, createdName=ymljack, createdTime=Mon May 02 18:31:42 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268576, encodeId=e20e12685e61f, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Jul 06 08:31:42 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488386, encodeId=2bc11488386e5, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Tue Jul 06 08:31:42 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026897, encodeId=ac43102689ec7, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Jul 04 20:31:42 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043681, encodeId=0e57104368143, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jul 04 20:31:42 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996160, encodeId=0734996160a7, content=年轻化的患病人群让我们很头疼, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b274784389, createdName=wwcq11240306, createdTime=Sun Jul 04 19:15:10 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996139, encodeId=6e81996139bd, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sun Jul 04 17:43:56 CST 2021, time=2021-07-04, status=1, ipAttribution=)]
    2021-07-04 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2018371, encodeId=134120183e122, content=<a href='/topic/show?id=5cac36039a1' target=_blank style='color:#2F92EE;'>#卒中幸存者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36039, encryptionId=5cac36039a1, topicName=卒中幸存者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6393434, createdName=ailian1202, createdTime=Sun May 01 13:31:42 CST 2022, time=2022-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645651, encodeId=a815164565139, content=<a href='/topic/show?id=79d99e04630' target=_blank style='color:#2F92EE;'>#长期预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97046, encryptionId=79d99e04630, topicName=长期预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e4823226485, createdName=ymljack, createdTime=Mon May 02 18:31:42 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268576, encodeId=e20e12685e61f, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Jul 06 08:31:42 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488386, encodeId=2bc11488386e5, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Tue Jul 06 08:31:42 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026897, encodeId=ac43102689ec7, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Jul 04 20:31:42 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043681, encodeId=0e57104368143, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jul 04 20:31:42 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996160, encodeId=0734996160a7, content=年轻化的患病人群让我们很头疼, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b274784389, createdName=wwcq11240306, createdTime=Sun Jul 04 19:15:10 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996139, encodeId=6e81996139bd, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sun Jul 04 17:43:56 CST 2021, time=2021-07-04, status=1, ipAttribution=)]
    2021-07-04 misszhang

    谢谢MedSci提供最新的资讯

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2018371, encodeId=134120183e122, content=<a href='/topic/show?id=5cac36039a1' target=_blank style='color:#2F92EE;'>#卒中幸存者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36039, encryptionId=5cac36039a1, topicName=卒中幸存者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6393434, createdName=ailian1202, createdTime=Sun May 01 13:31:42 CST 2022, time=2022-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645651, encodeId=a815164565139, content=<a href='/topic/show?id=79d99e04630' target=_blank style='color:#2F92EE;'>#长期预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97046, encryptionId=79d99e04630, topicName=长期预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e4823226485, createdName=ymljack, createdTime=Mon May 02 18:31:42 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268576, encodeId=e20e12685e61f, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Jul 06 08:31:42 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488386, encodeId=2bc11488386e5, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Tue Jul 06 08:31:42 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026897, encodeId=ac43102689ec7, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Jul 04 20:31:42 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043681, encodeId=0e57104368143, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jul 04 20:31:42 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996160, encodeId=0734996160a7, content=年轻化的患病人群让我们很头疼, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b274784389, createdName=wwcq11240306, createdTime=Sun Jul 04 19:15:10 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996139, encodeId=6e81996139bd, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sun Jul 04 17:43:56 CST 2021, time=2021-07-04, status=1, ipAttribution=)]
    2021-07-04 wwcq11240306

    年轻化的患病人群让我们很头疼

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2018371, encodeId=134120183e122, content=<a href='/topic/show?id=5cac36039a1' target=_blank style='color:#2F92EE;'>#卒中幸存者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36039, encryptionId=5cac36039a1, topicName=卒中幸存者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6393434, createdName=ailian1202, createdTime=Sun May 01 13:31:42 CST 2022, time=2022-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645651, encodeId=a815164565139, content=<a href='/topic/show?id=79d99e04630' target=_blank style='color:#2F92EE;'>#长期预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97046, encryptionId=79d99e04630, topicName=长期预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e4823226485, createdName=ymljack, createdTime=Mon May 02 18:31:42 CST 2022, time=2022-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268576, encodeId=e20e12685e61f, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Tue Jul 06 08:31:42 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488386, encodeId=2bc11488386e5, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Tue Jul 06 08:31:42 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026897, encodeId=ac43102689ec7, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Jul 04 20:31:42 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043681, encodeId=0e57104368143, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jul 04 20:31:42 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996160, encodeId=0734996160a7, content=年轻化的患病人群让我们很头疼, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b274784389, createdName=wwcq11240306, createdTime=Sun Jul 04 19:15:10 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996139, encodeId=6e81996139bd, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sun Jul 04 17:43:56 CST 2021, time=2021-07-04, status=1, ipAttribution=)]
    2021-07-04 yangchou

    好文章,谢谢分享。

    0

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Ann Allergy Asthma Immunol:哮喘和过敏性疾病不是COVID-19儿童住院的风险因素

COVID-19在2019年底出现大流行,导致大量人员感染并死亡。最近,有研究人员确定了过敏性疾病是否是COVID-19住院的风险因素。

柳叶刀:苏格兰大规模接种首剂COVID-19疫苗后,COVID-19住院人数减少

2019年12月,中国武汉爆发SARS-CoV-2疫情,随后被世界卫生组织宣布为新冠肺炎大流行。自大流行开始以来,截至2021年4月20日,全球223多个国家和地区报告了超过1.41亿例病例和300万

BMJ:各国covid-19住院患者药物治疗大不相同

covid-19大流行的最初几个月使用了多种药物,有很大的地理和时间差异。羟基氯喹、阿奇霉素、洛匹那韦-利托那韦和umifenovir (仅在中国)是处方最多的改用药物。

BMJ:出生胎龄与儿童期住院风险研究

胎龄与住院风险之间的关系随着年龄的增长而降低,但在整个儿童时期,即使是孕38-39周出生儿童,其住院风险也高于孕40周儿童

Heart:心力衰竭诊断中利钠肽水平及其与住院和死亡风险的关系

基线较高的NP水平与HF相关住院率增加和生存率降低相关。

Dig Dis Sci:基于急诊简单评分可预测炎性肠病患者的住院治疗风险

炎症性肠疾病(IBD)的疾病复发与住院治疗显著相关,虽然采用类固醇紧急治疗可以获得不错的疗效,但是仍有近40%的患者将经历疾病恶化的临床过程,并需要外科手术或