Chest:术前右心腔测量对主动脉瓣置换术后肺动脉高压评估的影响

2020-01-18 xiangting MedSci原创

在AVR后的长期预后评估中,将右心腔指标纳入PH概率模型中有助于更好地进行风险识别,尤其是在“中等”概率组中。

主动脉瓣狭窄患者的严重肺动脉高压(PH)与主动脉瓣置换术(AVR)后的预后不良有关。目前的欧洲PH指南建议在PH评估时将两个不同的超声心动图信号加入三尖瓣返流速度(TRV),将其概率分为TRV≤2.8m/s)、TRV 2.9-3.4m/s)和TRV>3.4m/s)。右心室(RV)是PH预后的重要决定因素。这项研究目的是分析右房面积>18cm2RV/左室比>1AVR术后长期预后中的价值,主要是中等概率组。

研究纳入了429例连续性患者(平均年龄73±8岁,男性占55%),中位随访时间为4.25年(完成率98%)。将患者分为n=247)、中等n=117)和概率组(n=65)。中等组被分为两个亚组:亚组2a”n=27TRV不可测量或≤2.8m/s,并且有2个信号)和亚组2b”n=90TRV 2.9-3.4m/s,没有或只有1个信号)。

随访期间“低”、“中”和“高”概率组的总死亡率分别为24%、32%和42%。”PH概率是全因死亡率的独立预测因子(HR 1.8295CI1.11-3.00),但是经过多因素分析后,中等组没有达到统计学显著性(HR 1.4095CI0.91- 2.16)。将中等组划分为亚组时,亚组2a”的死亡率(56%)高于亚组2b”24%,p=0.002)和概率组(24%,p<0.001)。经过多因素分析,与“低”概率组比较,亚组2a”的死亡率(HR 2.1395CI1.11-4.10)明显高于亚组2b”HR 1.2495CI0.75-2.05)。

AVR后的长期预后评估中,将右心腔指标纳入PH概率模型中有助于更好地进行风险识别,尤其是在中等概率组中。

原始出处:

Mercè Cladellas. Impact of preoperative right heart chambers measurement in the evaluation of pulmonary hypertension after aortic valve replacement. Chest. 17 January 2020.

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    2020-06-19 3631173
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createdName=Smile2680, createdTime=Wed Jul 08 04:56:00 CST 2020, time=2020-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051496, encodeId=02432051496a5, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Jul 01 11:56:00 CST 2020, time=2020-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742668, encodeId=1d4c1e4266858, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Wed Dec 09 14:56:00 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925309, encodeId=29851925309f8, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Feb 14 23:56:00 CST 2020, time=2020-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379738, encodeId=d9263e973867, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJ1w4YYR3HstX6mkYyFNeIW2FrP0jz2wYbTI9Gdt7GFibicI0H9BAf5x6WakmKtqbX6nG46gHia3Aib8w/132, createdBy=9e585255319, createdName=南山梯, createdTime=Thu Feb 27 20:22:57 CST 2020, time=2020-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332703, encodeId=208c1332e0329, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Mon Jan 20 02:56:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367201, encodeId=9afa136e20175, content=<a href='/topic/show?id=b6222320322' target=_blank style='color:#2F92EE;'>#主动脉瓣置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23203, encryptionId=b6222320322, topicName=主动脉瓣置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b24249, createdName=medsci246, createdTime=Mon Jan 20 02:56:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415605, encodeId=2d7b14156056b, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Mon Jan 20 02:56:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576753, encodeId=e9d715e675375, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Mon Jan 20 02:56:00 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-12-09 yxch48
  5. [GetPortalCommentsPageByObjectIdResponse(id=2033461, encodeId=6a1f20334619f, content=<a href='/topic/show?id=6dd73864454' target=_blank style='color:#2F92EE;'>#右心腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38644, encryptionId=6dd73864454, topicName=右心腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7a159, createdName=3631173, createdTime=Fri Jun 19 11:56:00 CST 2020, time=2020-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929607, encodeId=f7bd192960eeb, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJ1w4YYR3HstX6mkYyFNeIW2FrP0jz2wYbTI9Gdt7GFibicI0H9BAf5x6WakmKtqbX6nG46gHia3Aib8w/132, createdBy=9e585255319, createdName=南山梯, createdTime=Thu Feb 27 20:22:57 CST 2020, time=2020-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332703, encodeId=208c1332e0329, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Mon Jan 20 02:56:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367201, encodeId=9afa136e20175, content=<a 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time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576753, encodeId=e9d715e675375, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Mon Jan 20 02:56:00 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2033461, encodeId=6a1f20334619f, content=<a href='/topic/show?id=6dd73864454' target=_blank style='color:#2F92EE;'>#右心腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38644, encryptionId=6dd73864454, topicName=右心腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7a159, createdName=3631173, createdTime=Fri Jun 19 11:56:00 CST 2020, time=2020-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929607, encodeId=f7bd192960eeb, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, 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encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Wed Dec 09 14:56:00 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925309, encodeId=29851925309f8, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Feb 14 23:56:00 CST 2020, time=2020-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379738, encodeId=d9263e973867, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJ1w4YYR3HstX6mkYyFNeIW2FrP0jz2wYbTI9Gdt7GFibicI0H9BAf5x6WakmKtqbX6nG46gHia3Aib8w/132, createdBy=9e585255319, createdName=南山梯, createdTime=Thu Feb 27 20:22:57 CST 2020, time=2020-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332703, encodeId=208c1332e0329, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Mon Jan 20 02:56:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367201, encodeId=9afa136e20175, content=<a href='/topic/show?id=b6222320322' target=_blank style='color:#2F92EE;'>#主动脉瓣置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23203, encryptionId=b6222320322, topicName=主动脉瓣置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b24249, createdName=medsci246, createdTime=Mon Jan 20 02:56:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415605, encodeId=2d7b14156056b, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Mon Jan 20 02:56:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576753, encodeId=e9d715e675375, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Mon Jan 20 02:56:00 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-02-27 南山梯

    值得学习

    0

  7. 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JACC:严重主动脉瓣狭窄患者随访期间的左心室射血分数下降

在保守治疗的情况下,与LVEF无下降相比,确诊1年后LVEF下降>10%的严重AS患者AS相关临床结局更差。

JAHA:经导管主动脉瓣植入心肌血运重建的生理vs.血管造影引导

在这项观察性研究中,FFR引导与经导管主动脉瓣植入患者较好的预后相关。

JACC:低外科风险AS患者TAVR依旧是一个更好的选择

对于低外科手术风险的严重主动脉瓣狭窄(AS)患者,经导管主动脉瓣置换术(TAVR)较外科手术的术后1年死亡风险、卒中和再住院风险更低。然而,治疗策略对患者健康状态的影响尚不清楚。本研究的目的旨在比较和评估接受TAVR和外科手术治疗的低风险AS患者的术后健康状态。本研究纳入了PARTNER 3临床试验中的1000名低风险AS患者,并将其随机分成经股TAVR组和外科组,并在基线时、术后1月、6月和12

NEJM:无症状主动脉瓣狭窄患者应选择早期手术还是保守治疗?

由此可见,在无症状严重主动脉瓣狭窄患者中,接受早期主动脉瓣膜置换手术的患者在随访期间因心血管原因而导致的手术死亡或死亡的复合结局发生率显著低于接受保守治疗的患者。