Hypertension:较差的肺功能会加速动脉硬化吗?

2019-08-06 xing.T MedSci原创

总之,较差的肺功能预测未来的动脉僵硬度。这些研究结果支持肺功能作为动脉僵硬度的临床重要危险因素,并为将来根据其与动脉硬度的关系进行的肺功能干预研究提供理由。

由于先前的观察性研究尚未评估与早期肺功能相关的动脉僵硬度的纵向变化,因此较差的肺功能是否加速动脉硬化的进展仍然未知。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,数据(n=5342,女性占26%)来自Whitehall II队列研究。参与者在5年内完成了1秒内用力呼气量(FEV1,L)和颈动脉-股动脉脉搏波速度(cf-PWV,m/s)的重复评估。研究人员使用线性混合效应模型估计FEV1对晚期cf-PWV及其进展的影响,并评估了可能的解释机制,例如低级别全身性炎症、先前存在的心脏代谢危险因素的常见原因解释和反向因果关系偏倚。

在调整年龄、性别、种族、心率和平均动脉压后,较差的肺功能与晚期较高的cf-PWV及其随后的进展相关(FEV1每降低1个SD的cf-PWV5年变化为0.09,95%CI为0.03-0.17/)。肺功能的下降与后来更高的cf-PWV相关(0.17,95%CI为0.04-0.30,与FEV1下降的最低四分位数相比)。没有证据支持通过循环CRP(C-反应蛋白)或IL(白细胞介素)-6来进行介导。此外,在考虑心脏代谢状态后,动脉硬度与后来的FEV1无关。

总之,较差的肺功能预测未来的动脉僵硬度。这些研究结果支持肺功能作为动脉僵硬度的临床重要危险因素,并为将来根据其与动脉硬度的关系进行的肺功能干预研究提供理由。 

原始出处:
 
Masaki Okamoto.et al.Does Poorer Pulmonary Function Accelerate Arterial Stiffening? A Cohort Study With Repeated Measurements of Carotid-Femoral Pulse Wave Velocity.Hypertension.2019.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13183

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    2019-09-25 feather89
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    2019-08-09 一天没事干

    很好的学习机会

    0

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    2019-08-08 一天没事干

    很好的学习机会

    0

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    2019-08-06 一天没事干

    很好的学习机会

    0

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