Evid Based Complement Alternat Med:如何利用代谢组学辨别中医的体质?

2022-06-26 August MedSci原创

北京中医药大学王琦教授开发的《中医体质分类标准》和《中医体质九大体质分类量表》是目前公认的中医体质诊断标准。

体质是指人类个体生命过程中遗传或后天获得的形态结构、生理功能和心理状态的综合而相对稳定的特征。建立了一种特殊的代谢组学数据处理方法来寻找唯一的m/z每个宪法的价值。结合随机森林决策树算法,构建了中医9种体质的判别模型,并对模型进行了验证和检验。测试结果表明,每种体质的分类准确率均高于80%,说明该模型能够很好地识别出中医的九种体质。分类精度与体质区分的难易程度有关。此研究为中医体质鉴别提供了一种快速、准确的方法,为中医临床体质的分类判断提供了客观的表征,为中医现代化提供了科学依据。

平和体质及8种偏体质标准表:

八种偏向体质的m/z值与平和体质的比较:

中医体质通过研究人体的生理、病理反应状态和个体差异,将人分为不同的体质类型,探讨不同体质类型与疾病之间的关系,进而通过干预不同的体质来实现防病治病的目的。有研究分析和讨论了中医体质鉴定的历史沿革,中医体质鉴定对辨证论治的指导,以及中医体质鉴定对防治COVID-19的指导意义。他们提出应用中医体质识别理论分析不同人群的体质特征,进行早期干预和矫正。可降低COVID-19的发病率,对COVID-19的治疗应根据地域和气候差异,结合不同个体的体质特点,做到辨证体质相结合,提高临床疗效。为中医体质鉴定在COVID-19防治中的应用提供理论参考。

一些研究表明中医体质是影响社区居民心血管疾病发生的危险因素,其中气虚、阴虚、瘀血、血虚等偏质体质人群患心血管疾病的风险显着升高。表明痰湿质、阳虚质和湿热质是多囊卵巢综合征(PCOS)患者的主要偏向体质类型,痰湿质、湿热质和血瘀质可能是多囊卵巢综合征(PCOS)发生的危险因素。另外,酒精性肝病患者的体质特征为湿热体质,而酒精性肝炎患者的体质特征则倾向于气滞体质和血瘀体质。酒精性肝硬化患者的体质偏血瘀体质和痰湿体质。

体质鉴别模型的测试结果。(a) 正模式条件下的测试结果。(b) 负模式条件下的测试结果。

综上所述,这些研究表明体质类型与疾病密切相关,中医体质鉴定是判断个体不同体质类型的重要方法。中医体质鉴定已经并将继续在指导中医师防治人类疾病方面发挥重要作用。研究基于代谢组学数据,构建了中医九体质的判别模型,提出了新的方法和思路。模型库可以不断扩充数据,不断接受每个体质的新特征信息,有望能够识别多个样本,实现体质的客观、科学、快速识别。虽然本研究可为中医体质鉴别提供客观依据,但仍需更多研究进一步探索各种体质作用机制的差异。简言之,通过良好的体质鉴定可以预防和治疗疾病。

 

原文:Huang C, Chen Y, Li B, Zhang Q, Jiang L, Nie B, Chen L, Jian H, Xu G. Traditional Chinese Medicine Constitution Discrimination Model Based on Metabolomics and Random Forest Decision Tree Algorithm. Evid Based Complement Alternat Med. 2022 May 16;2022:3490130. doi: 10.1155/2022/3490130. PMID: 35615685; PMCID: PMC9126728.

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    2023-04-19 w363522449
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    2022-09-02 liye789132251
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    2023-01-21 shizhenshan
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    2022-07-14 般若傻瓜
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    2022-11-03 zsyan
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    2022-08-26 xuyong536
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