Eur J Heart Fail:超声心动图确定的射血分数变化与长期死亡率的关系

2021-04-18 MedSci原创 MedSci原创

这些数据来自大型队列的成年人随访,其结果表明适度的LVEF变化可能具有重要的临床意义。

近日,血管领域权威杂志European Journal of Heart Failure上发表了一篇研究文章,研究人员旨在调查大型真实世界患者队列中与左心室喷射分数(LVEF)变化相关的长期死亡率。

该研究共纳入了117275名成人(63±16岁,46%为女性),他们在6个月以上的间隔期内通过相同方法进行了LVEF测量。该研究纳入了17343例最初针对心力衰竭(HF)进行了筛查的患者(66±15岁,48%为女性)。

从第一至最后一个超声心动图检查的3.3年(四分位间距范围(IQR)为1.7-6.0)期间,LVEF的中位数变化为-1(IQR为-8至+5)个单位,相比于基线降低62%(IQR为54-69%)。

在后续7.6年(IQR为4.3-10.1)随访期间,分别有11397(9.7%)和34101(29.1%)名患者死于心血管疾病和全因死亡。在5年时间里,LVEF降低程度从最小到最大(从<5个单位到>30个单位)的患者全因死亡率从12%增加至29%;心血管相关死亡率的调整风险增加了2至8倍。在最初筛查HF的患者中(32%的患者初始LVEF<50%),心血管相关死亡率的调整后风险比范围为从0.35 [95%置信区间(CI)为0.28-0.49]至4.21(95%CI为3.30-5.22 )。

这些数据来自大型队列的成年人随访,其结果表明适度的LVEF变化可能具有重要的临床意义

原始出处:

Geoff Strange.et al.Change in ejection fraction and long‐term mortality in adults referred for echocardiography.European journal of heart failure.2021.https://doi.org/10.1002/ejhf.2161

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    2021-10-30 a little

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    2021-08-02 青~

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    2021-05-01 1581f8c42cm

    学习

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    2021-04-20 zhaojie88
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    2021-04-20 slcumt
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    2021-04-19 ms5991543816394679

    棒棒哒

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    2021-04-19 ZJY

    I've been taught

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