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JAMA Intern Med：阿哌沙班血栓预防可显著降低心衰患者骨折风险

2019-11-27 MedSci MedSci原创

骨折血栓阿哌沙班心衰
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研究认为，对于心衰患者使用直接口服抗凝剂，特别是阿哌沙班，可降低骨折风险

华法林可用于预防房颤(AF)患者血栓事件，但华法林治疗导致患者骨折风险增加。近日研究人员考察了直接口服抗凝剂(DOAC)的骨折风险。

非瓣膜性AF患者参与研究，随机接受华法林或DOACs(达比加群酯、利伐沙班和阿哌沙班)。研究的主要终点为髋部骨折、需住院治疗骨折以及全部骨折。

167275名AF患者，38.0%为女性，平均年龄68.9岁，平均随访16.9个月，共发生817例髋部骨折、2013例需住院治疗骨折和7294例全部临床骨折。调整后，相对于华法林使用者， DOACs使用者需要住院治疗的骨折(0.87) 风险较低，但所有临床骨折(0.93)以及髋部骨折 (0.91)则无统计学意义。单个DOACs与华法林相比，阿哌沙班可降低髋部骨折（0.67）、需要住院治疗的骨折（0.60）以及所有临床骨折（0.86）风险。在亚组分析中， DOACs 对骨质疏松症的AF患者更为有益。

研究认为，对于心衰患者使用直接口服抗凝剂，特别是阿哌沙班，可降低骨折风险。

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    2019-11-29 yuanming7

    #心衰患者#

    0

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    2019-11-29 heli0118

    #骨折风险#

    0

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    2019-11-29 12498cf9m38(暂无昵称)

    #血栓预防#

    0

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    2019-11-29 ms3994565386320060

    #Med#

    0

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    2019-11-27 旺医

    顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息

    0

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