JAMA Netw Open:孕妇体重情况与儿童过敏性疾病有何关系?

2020-10-04 AlexYang MedSci原创

最近,有研究人员蒂阿查了孕产妇孕前体重指数和妊娠体重增加(GWG)与儿童过敏性疾病风险的关系,包括了哮喘和/或喘息、过敏性鼻炎、湿疹、食物和/或药物过敏。

最近,有研究人员蒂阿查了孕产妇孕前体重指数和妊娠体重增加(GWG)与儿童过敏性疾病风险的关系,包括了哮喘和/或喘息、过敏性鼻炎、湿疹、食物和/或药物过敏。

研究是一个项横断面研究,在2019年4月12日至6月1日进行,研究包括了15 145对母子。研究发现,在SCAS内15145名3至14岁儿童(7911[52.2%]男孩)中,8877名儿童(58.6%)接受了过敏性疾病的筛查。多变量对数二项回归模型表明,GWG过高与儿童19%的哮喘/打喷嚏风险、过敏性鼻炎11%的风险和10%湿疹风险有关。妊娠前超重/肥胖的妇女妊娠体重增加高于医学研究所指南时,则与儿童哮喘/打喷嚏(调整后的患病率比,1. 42;95%CI,1.16-1.74;P=0.001)、过敏性鼻炎(调整后的患病率比,1.32;95%CI,1.12-1.56;P=0.001)和湿疹(调整后的患病率比,1.24;95%CI,1.08-1.41;P=0.002)的最高风险相关。当母亲孕前体重正常且妊娠体重增加低于医学研究所指南时,则与儿童哮喘/打喷嚏的风险减弱13%、过敏性鼻炎的风险减弱11%、湿疹的风险减弱14%、食物/药物过敏的风险减弱15%有关;另外,研究人员在体重不足的母亲中观察到相似的关联,但在超重母亲中没有发现上述关联。一般来说,根据儿童年龄组进行分层分析时,关联性相似。此外,在过敏原检测亚组中,结果也相似。

孕产妇BMI和GWG与儿童过敏疾病关联分析

最后,研究人员指出,过高的GWG可能是儿童过敏性疾病的一个风险因素。进一步研究宫内环境对儿童健康的长期影响时可能会考虑到孕期母体体重管理,且GWG是一个可控和可改变的风险因素。

原始出处:

Yiting Chen , Jianzhen Zhu , Jiajun Lyu et al. Association of Maternal Prepregnancy Weight and Gestational Weight Gain With Children's Allergic Diseases. JAMA Netw Open. Sep 2020

 

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    2021-07-08 canlab
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    2021-01-10 zutt
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    2020-12-17 feather89
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    2020-10-05 1240394fm61暂无昵称

    学习

    0

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    2020-10-04 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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