Science Immunol:COVID-19-急性呼吸窘迫综合征患者的SARS-CoV-2特异性T细胞的表型和动力学

2020-06-28 MedSci原创 MedSci原创

SARS-CoV-2已被确定为全球呼吸道疾病 (COVID-19)暴发的病原体。在某些患者中,感染导致中度至重度急性呼吸窘迫综合征(ARDS),需要进行有创的机械通气。高血清水平的IL-6、IL-10

SARS-CoV-2已被确定为全球呼吸道疾病 (COVID-19)暴发的病原体。在某些患者中,感染导致中度至重度急性呼吸窘迫综合征(ARDS),需要进行有创的机械通气。高血清水平的IL-6、IL-10和免疫高反应性被称为“细胞因子风暴”,与临床预后不良有关。

尽管已有大量的COVID-19感染病例和死亡病例,但有关SARS-CoV-2特异性T细胞的表型和动力学的信息仍然有限。

Weiskopf等人研究了10位需要在重症监护病房治疗的COVID-19患者,分别在10位和8位患者中检测到了SARS-CoV-2特异性CD4 +和CD8 + T细胞。此外,研究人员还从以前未接触过SARS-CoV-2的2位健康对照(共检测了10人)中检测到了低水平的SARS-CoV-2-反应性T细胞,提示由于过去感染过“普通感冒”的冠状病毒而产生了交叉反应。

最强的T细胞反应针对的是突触(S)表面糖蛋白,SARS-CoV-2特异性T细胞主要产生效应因子和Th1细胞因子,虽然也检测到了Th2和Th17细胞因子。

此外,研究人员通过对T细胞动力学进行研究发现,SARS-CoV-2特异性T细胞出现相对较早,而且随时间的推移而增加。

总之,本研究数据揭示了指示疾病严重程度的T细胞应答的潜在变化,这一问题对于理解免疫病理在该病中的潜在作用至关重要,同时也为疫苗设计和评估提供了依据。

原始出处:

Daniela Weiskopf, et al. Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome. Science Immunology. 26 Jun 2020: Vol. 5, Issue 48, eabd2071. DOI: 10.1126/sciimmunol.abd2071

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    2020-12-03 hukaixun
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    2020-07-22 nxwyy

    👍

    0

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    2020-06-30 小刀医生
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    2020-06-30 jichang
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    2020-06-30 tastas
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单克隆抗体ALT-100或可用于急性呼吸窘迫综合征(ARDS)和呼吸机诱发的肺损伤(VILI)

Aqualung Therapeutics正在开发治疗性单克隆抗体ALT-100以抵抗严重的炎症,旨在降低急性呼吸窘迫综合征(ARDS)和呼吸机诱发的肺损伤(VILI)的死亡率。