JAHA:计算机断层扫描血管造影术中缺血性卒中相关的的更佳颈动脉斑块特征

2021-02-17 MedSci原创 MedSci原创

对同侧颈动脉所致卒中的最佳识别信息包括腔内血栓、最大软斑厚度和轮缘征。这些结果不支持仅使用颈动脉狭窄来确定CTA的卒中来源,表明这些替代标记可能更好地诊断易损斑块并指导治疗决策。

颈动脉狭窄一直以来都被认为是颈动脉所致卒中的主要因素。最近的证据表明,在影像学上检测到的特定斑块特征与缺血性卒中的相关程度可能比颈动脉狭窄更高。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员试图明确能够较好地区分同侧卒中来源的颈动脉斑块的计算机断层血管造影(CTA)影像学特征。

在这项回顾性横断面研究中,研究人员对494例接受同侧颈CTA脑磁共振成像检查的患者进行分析,排除了有其他卒中来源的患者。研究人员记录了受试者的颈动脉CTA和临床标志物,拟合多元Poisson回归模型。研究人员使用受试者工作特性分析、曲线下面积和自举验证确定区分性能。

最终的CTA颈动脉所致卒中预测模型包括管腔内血栓(患病率为2.8 [P<0.001];95%CI为1.6-4.9)、最大软斑厚度(患病率为1.2 [P<0.001];95%CI为1.1-1.4)和轮缘征(患病率为2.0 [P=0.007];95%CI为1.2-3.3)。最终区分数值(曲线下面积=78.3%)高于腔内血栓(56.4%,P<0.001)、最大软斑厚度(76.4%,P=0.007)或仅轮缘征(69.9%,P=0.001)。此外,NASCET(北美症状性颈动脉内膜切除术试验)中狭窄分类(临界值分别为50%和70%)对卒中的识别率较低(曲线下面积=67.4%,P<0.001)。

由此可见,对同侧颈动脉所致卒中的最佳识别信息包括腔内血栓、最大软斑厚度和轮缘征。这些结果不支持仅使用颈动脉狭窄来确定CTA的卒中来源,表明这些替代标记可能更好地诊断易损斑块并指导治疗决策

原始出处:

Hediyeh Baradaran.et al.Optimal Carotid Plaque Features on Computed Tomography Angiography Associated With Ischemic Stroke.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.019462

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    2021-07-01 bioon14
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  7. 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    2021-02-23 ms7000001204488220

    学习了

    0

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    2021-02-18 zhaohui6731
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