Diabetes Care:有饮食失调的T1DM患者的DKA和死亡风险分别增加了3倍和6倍!

2021-08-16 Nebula MedSci原创

与没有饮食失调病史的同龄人相比,有饮食失调病史的1型糖尿病青少年和年轻成人患者患DKA的风险增加了三倍以上,死亡风险增加了近六倍!

饮食失调是一种复杂的心理健康状况,其特征是饮食行为异常和身体形象受损。饮食失调包括神经性厌食症、神经性贪食症、暴食症和其他特定的进食障碍。与没有糖尿病的同龄人相比,1型糖尿病青少年和年轻成人患者的饮食失调更常见

该研究旨在确定患有或不患有饮食失调的1型糖尿病青少年和年轻成人发生糖尿病酮症酸中毒 (DKA) 的风险和全因死亡率。

使用覆盖加拿大安大略省全部人口的人口级卫生保健管理数据,纳入截止2014年1月确诊的所有10-39岁的1型糖尿病患者。给有饮食失调病史的患者以10:1匹配年龄和性别比例相当的无饮食失调病史的患者。所有受试者至少随访6年,以评估其因DKA住院/急诊的发生率以及全因死亡率。

有无饮食失调的1型糖尿病患者的DKA发生率

总体上,共纳入了168位有饮食失调史的1型糖尿病患者和1680位年龄、性别相匹配的无饮食失调史的患者。在1型糖尿病青少年和年轻成人患者中,有饮食失调病史的患者占比0.8%。在有饮食失调史的患者中,DKA的粗略发生率为112.5/1000人·年;在无饮食失调史的患者中,DKA发生率为30.8/1000人·年。

有无饮食失调的1型糖尿病患者的存活率

根据基线差异进行校正后,比较有/无饮食失调的患者的分布风险比为3.30(95%CI 2.58-4.23;p<0.0001)。有饮食失调史的患者的全因死亡率为16.0//1000人·年,而无饮食失调史的患者的为2.5/1000人·年(校正风险比 5.80[95%CI 3.94-11.08];p<0.0001)。

简而言之,与没有饮食失调病史的同龄人相比,有饮食失调病史的1型糖尿病青少年和年轻成人患者患DKA的风险增加了三倍以上,死亡风险增加了近六倍!

原始出处:

Nicole K. Gibbings, et al. Diabetic Ketoacidosis and Mortality in People With Type 1 Diabetes and Eating Disorders. Diabetes Care 2021 Aug; 44(8): 1783-1787. https://doi.org/10.2337/dc21-0517

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