BMJ:慢性腹泻与非酒精性脂肪肝病和肥胖相关疾病的关系

2019-09-13 不详 MedSci原创

目前学界对于腹泻和肥胖之间的关联或增加的体重指数(BMI)的机制尚不清楚。因此,本项研究旨在评估肠道模式与BMI,代谢综合征(MS),非酒精性脂肪性肝病(NAFLD)和其他肥胖相关疾病的关系。

背景及目的:
目前学界对于腹泻和肥胖之间的关联或增加的体重指数(BMI)的机制尚不清楚。因此,本项研究旨在评估肠道模式与BMI,代谢综合征(MS),非酒精性脂肪性肝病(NAFLD)和其他肥胖相关疾病的关系。

方法:
研究人员对2005年至2010年全国健康和营养检查调查中完成肠道健康问题调查问卷的成年人的数据进行了横断面分析。使用多项Logistic回归分析关系。通过顺序建模检验人口统计学,吸烟,酒精和BMI的混杂影响。

结果:
本项研究共纳入13413名成人,便秘和腹泻患病率分别为8.9%和6.6%。平均BMI与肠道模式相关(p <0.001),腹泻(30.3 kg / m 2)与正常肠道模式(28.6 kg / m 2)和腹泻与便秘(27.8 kg / m 2)相比更高。在调整分析中,NAFLD在腹泻与正常肠道模式(OR = 1.34,95%CI 1.01至1.78)或便秘(OR = 1.45,95%CI 1.03,2.03)中更为普遍(ORs,95%CI)。腹泻与便秘的MS患病率较高(OR = 1.27,95%CI 0.97-1.67)。

结论:
本项研究结果表明腹泻与NAFLD之间存在关联,但与BMI无关。

原始出处:

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    2020-01-29 gaoxiaoe
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