Clinica Chimica Acta:循环外胞浆菌素A是非酒精性脂肪肝的潜在生物标志物?

2019-12-21 MedSci MedSci原创

胞外质体A (EDA)是一种新的可能参与能量代谢的肝细胞因子。本研究旨在1)探讨EDA在C57BL/6小鼠和HepG2细胞肝脂肪变性中的作用;2)评价血清EDA在人非酒精性脂肪肝(NAFLD)中的作用。

胞外质体A (EDA)是一种新的可能参与能量代谢的肝细胞因子。本研究旨在1)探讨EDAC57BL/6小鼠和HepG2细胞肝脂肪变性中的作用;2)评价血清EDA在人非酒精性脂肪肝(NAFLD)中的作用。

本研究包括体外和体内实验研究和基于医院的病例对照研究。采用Western blottingqPCRELISA检测EDA水平。siRNAshRNA来敲除EDA。采用脂肪磁珠法测定血清脂肪因子。

体内和体外均在脂肪肝中检测到肝脏和分泌的EDA水平升高。EDA在体外可改善脂肪变性,而在体内可提高肝内甘油三酯含量和肝酶活性。EDA基因表达上调,脂溶性基因表达上调,脂质基因表达抑制。NAFLD患者血清EDA水平较高。此外,它揭示了循环EDA和更高的NAFLD发病几率之间的联系,而循环EDA在识别NAFLD方面具有一定的实用价值。最后,血清EDA水平依赖于BMI, TNF-α,2糖尿病和肥胖。

EDA通过在脂质沉积和消除之间达到平衡而加重脂肪沉积。它是NAFLD潜在的生物标志物。

原始出处:

Ji YangWenjing ZhouCirculating ectodysplasin A is a potential biomarker for nonalcoholic fatty liver disease

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    2020-03-16 windight
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    2019-12-22 thm112988

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