Neurology:白质高信号标志与死亡和缺血性卒中长期风险之间的关联

2021-03-19 MedSci原创 MedSci原创

WMH体积、类型和形状与症状性动脉疾病患者的长期死亡和缺血性卒中风险相关。

近日,神经病学领域权威杂志Neurology上发表了一篇研究文章,该研究旨在明确MRI上的白质高信号(WMH)标记是否与患者长期死亡和缺血性卒中风险相关。

研究人员纳入了SMART-MR研究中患有明显动脉疾病的患者。研究人员使用自动化算法从基线进行的脑部MRI扫描中获得了WMH标记(体积、类型和形状)。在随访期间,记录了受试者死亡和缺血性卒中的发生情况。研究人员通过Cox回归,评估了WMH标志与死亡和缺血性卒中风险之间的相关性,并根据人口统计学、血管疾病危险因素和脑血管疾病进行了调整。

研究人员纳入了999例患者(59±10岁;男性占79%),随访12.5年(范围为0.2-16.0年)。脑室周围或融合的WMH量增加与血管性死亡的风险增加(风险比[HR]为1.29,95%CI为1.13-1.47)和缺血性卒中(HR=1.53,95%CI为1.26–1.86)相关。融合的WMH类型与血管性死亡(HR=2.05,95%CI为1.20–3.48)和非血管性死亡(HR=1.65,95%CI为1.01–2.73)和缺血性卒中(HR=4.01,95%CI为1.72–9.35)更大风险独立相关。以凹度指数衡量的更不规则的脑室周围或融合型WMH形状独立地与更大的血管性(HR=1.20,95%CI为1.05–1.38)和非血管性死亡(HR=1.21,95%CI为1.03–1.42)和缺血性卒中(HR=1.28,95%CI为1.05–1.55)风险相关。

由此可见,WMH体积、类型和形状与症状性动脉疾病患者的长期死亡和缺血性卒中风险相关。

原始出处:

Rashid Ghaznawi.et al.Association of White Matter Hyperintensity Markers on MRI and Long-term Risk of Mortality and Ischemic Stroke The SMART-MR Study.Neurology.2021.https://doi.org/10.1212/WNL.0000000000011827

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    2021-04-06 yinhl1978
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    2021-03-19 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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