Gastroenterology :外源性激素与女性致显微镜下结肠炎风险

2018-08-23 zhangfan MedSci原创

女性使用外源性激素导致显微镜下结肠炎风险增加

显微镜下结肠炎是一种慢性炎症性疾病,主要影响绝经后妇女。近日研究人员就激素决定因素,包括生殖和绝经因素,与显微镜下结肠炎之间的关系进行了考察。

NHS研究包含22766名女性参与者,参与者基线无显微镜下结肠炎史,参与者在1988-1989年接受生殖和更年期因素评估,并在2年内进行复查,根据病理记录评估显微镜下结肠炎,采用COX比例风险模型考察生殖和绝经因素与显微镜下结肠炎之间的相关性。

在5147282个随访年中,发生了275例显微镜下结肠炎。相对于从未接受过停经后荷尔蒙治疗的女性,正在接受停经后荷尔蒙治疗的女性其显微镜下结肠炎风险增加(HR=2.64),长期接受停经后荷尔蒙治疗或者减量停药人群风险仍然增加。有口服避孕药使用史人群的显微镜下结肠炎风险增加(HR=1.57)。月经初潮年龄、分娩次数、头胎年龄、更年期年龄、更年期类型和事件与显微镜下结肠炎不相关。

研究认为,女性使用外源性激素导致显微镜下结肠炎风险增加。

原始出处:


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    2019-07-28 zhangph
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    2019-05-14 许安
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  6. [GetPortalCommentsPageByObjectIdResponse(id=2029041, encodeId=0b9d202904124, content=<a href='/topic/show?id=a6bf4288e6f' target=_blank style='color:#2F92EE;'>#外源性激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42887, encryptionId=a6bf4288e6f, topicName=外源性激素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Jan 09 22:43:00 CST 2019, time=2019-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711595, encodeId=141c1e11595e1, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Mon Jan 28 18:43:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989780, encodeId=19231989e80f9, content=<a href='/topic/show?id=5c3c428850d' target=_blank style='color:#2F92EE;'>#外源性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42885, encryptionId=5c3c428850d, topicName=外源性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sun Jul 28 15:43:00 CST 2019, time=2019-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072250, encodeId=7c3e20e225050, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Tue May 14 08:43:00 CST 2019, time=2019-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064454, encodeId=4fdc20644545d, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Sep 14 15:43:00 CST 2018, time=2018-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341145, encodeId=61e83411452f, content=哈哈哈,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1ee1608797, createdName=huangshang9812, createdTime=Mon Aug 27 14:20:47 CST 2018, time=2018-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893784, encodeId=e4bc1893e8406, content=<a href='/topic/show?id=ab2159e343a' target=_blank style='color:#2F92EE;'>#显微镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59734, encryptionId=ab2159e343a, topicName=显微镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Tue Apr 16 06:43:00 CST 2019, time=2019-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1286383, encodeId=642b12863834c, content=<a href='/topic/show?id=24395268347' target=_blank style='color:#2F92EE;'>#性激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52683, encryptionId=24395268347, topicName=性激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sat Aug 25 00:43:00 CST 2018, time=2018-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504451, encodeId=4b7615044519e, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Aug 25 00:43:00 CST 2018, time=2018-08-25, status=1, ipAttribution=)]
    2018-08-27 huangshang9812

    哈哈哈,学习了

    0

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    2019-04-16 tulenzi
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