JAHA:肺动脉高压患者缺血性卒中预后的性别差异

2021-03-10 MedSci原创 MedSci原创

PH与住院死亡率没有显著的相关性,但与住院时间延长和不良出院结局相关。男性PH患者比女性PH患者更有可能住院期间死亡。

已有充分的证据证实全身性高血压与脑血管疾病之间的相关性。然而,肺动脉高压(PH)对急性缺血性卒中预后的影响尚未明确,尽管PH被认为是急性缺血性卒中的危险因素。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在明确PH与急性缺血性卒中后不良住院结局之间的关系,以及这种相关性是否存在性别差异。

该研究纳入了2015年10月至2017年12月期间美国全国住院患者样本中急性缺血性卒中入院病例。研究人员采用logistic回归分析了PH与结局(死亡率、住院时间延长4天以上和常规出院)之间的关系,并调整了人口统计学、合并症和血管重建治疗。PH与性别和年龄组之间的相互作用也纳入进行分析。

研究人员共纳入了1106045名患者的221249次住院病历;2.9%的患者伴有PH,其中35.34%为男性。PH与患者住院死亡率无关(比值比[OR]为0.96;95%CI为0.86-1.09),但与住院时间延长几率增加(OR为1.15;95%CI为1.09-1.22)和常规出院几率降低(OR为0.87;95%CI为0.81-0.94)相关。与年轻患者相比,老年PH患者常规出院的几率显著降低(P=0.028)。与女性PH患者相比,男性PH患者住院死亡的几率高出31% (P=0.024)。

由此可见,PH与住院死亡率没有显著的相关性,但与住院时间延长和不良出院结局相关。男性PH患者比女性PH患者更有可能住院期间死亡。

原始出处:

Tiberiu A. Pana.et al.Sex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.019341

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    2021-03-11 医者仁心
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    2021-03-11 Lizhihua6

    学习了

    0

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    2021-03-10 科研科研科研

    肺动脉高压患者

    0

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    2021-03-10 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2021-03-10 明天jing

    肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。

    0

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