CLIN CHEM LAB MED:高c反应蛋白/原降钙素比值可预测肺炎支原体感染?

2019-11-17 MedSci MedSci原创

目前,鉴别肺炎支原体(MP)与肺炎链球菌(SP)和社区获得性肺炎(CAP)病毒病因仍具有难度,但同时者对经验性抗生素治疗具有重要意义。本研究调查病人入院时的参数来预测MP感染。

目前,鉴别肺炎支原体(MP)与肺炎链球菌(SP)和社区获得性肺炎(CAP)病毒病因仍具有难度,但同时者对经验性抗生素治疗具有重要意义。本研究调查病人入院时的参数来预测MP感染

研究纳入所有2013年至2017年在三级护理医院住院的确诊病因为CAP的患者,使用logistic回归分析和ROC曲线下面积来分析人口学、临床和实验室特征与病原体之间的关系。

研究总共分析了568CAP患者,其中47(8%)MP152(27%)患有SP, 369(65%)患有流感或其他病毒。通过多因素logistic回归分析比较MPSP,年龄较小([OR]100.5695CI 0.42-0.73),中性粒细胞/淋巴细胞比率较低(OR 0.90.82-0.99)和C-升高 活性蛋白/降钙素(CRP / PCT)比率(截止值为400 mg /μgOR 15.04 [5.23–43.26])可独立预测MP ROC曲线的AUC0.91(对于> 400 mg /μg临界值为0.80),CRP / PCT比是MPSP的最强预测指标。 由于MPPCT值显著降低(p < 0.001),而CRP在两组中均较高(p = 0.057),因此具有鉴别价值。比较MP和病毒感染CRP/PCT比值的结果相似(AUC 0.83;> 400毫克/μg截止5.55,2.26 - 13.64)

研究表明,在因肺炎支原体感染住院的患者中,高住院CRP/PCT比值可预测肺炎支原体感染,并可改善经验性管理

原始出处:

Olivia L. NeeserTanja VukajlovicA high C-reactive protein/procalcitonin ratio predicts Mycoplasma pneumoniae infection

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    2019-11-18 yjs木玉

    好好好好好好

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