Clin Infect Dis:头孢托罗VS.万古霉素加阿曲南治疗急性细菌性皮肤和皮肤结构感染的疗效

2021-12-02 MedSci原创 MedSci原创

开发对革兰阳性和阴性细菌都有效的新型广谱抗生素,可能有益于提高急性细菌性皮肤和皮肤结构感染(ABSSSI)的治疗方案。本文对比了头孢托罗和万古霉素加阿兹雷治疗ABSSSI的疗效。

开发对革兰氏阳性和革兰氏阴性细菌都有效的新型广谱抗生素可能有益于提高急性细菌性皮肤和皮肤结构感染(ABSSSI)的治疗方案。头孢托罗是一种先进的静脉注射头孢菌素,在体外对革兰氏阳性(包括耐甲氧西林的金黄色葡萄球菌)和革兰氏阴性病原体具有广泛的活性。TARGET是一项随机、双盲、主动控制、平行分组、多中心的3期非劣效研究,比较了头孢匹罗与万古霉素加阿兹雷南,研究结果已发表于Clin Infect Dis。

食品和药物管理局定义的主要疗效终点是治疗开始后48-72小时的早期临床反应,欧洲药品管理局定义的主要终点是研究人员评估的治愈试验(TOC)时的临床成功。非劣效性被定义为成功率差异(头孢托罗减去万古霉素/阿曲南)的95%CI下限>-10%。通过不良事件和实验室数据收集来评估治疗的安全性。

结果,总共有679名患者被随机分配到头孢托罗(n = 335)或万古霉素/阿曲南(n = 344)。分析结果显示,头孢托罗组和万古霉素/阿曲南组的早期临床成功率分别为91.3%和88.1%,并显示出非劣效性(校正后差异:3.3%;95%CI:-1.2, 7.8)。在TOC访问中,研究者评估的临床成功率在两组之间相似,ITT(90.1% vs 89.0%)和临床可评估(97.9% vs 95.2%)人群都显示出非劣效性。两个治疗组都显示出类似的微生物学成功和安全状况。

综上所述,TARGET研究结果显示,从早期临床反应和研究者评估的TOC访问的临床成功率来看,头孢托罗在治疗ABSSSIs方面不逊于万古霉素/阿曲南。

 

原始出处:

 

J Scott Overcash, et al., Ceftobiprole Compared With Vancomycin Plus Aztreonam in the Treatment of Acute Bacterial Skin and Skin Structure Infections: Results of a Phase 3, Randomized, Double-blind Trial (TARGET). Clin Infect Dis. 2021 Oct 5;73(7):e1507-e1517. doi: 10.1093/cid/ciaa974.

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    2022-09-07 小小医者

    #头孢托罗#VS.#万古霉素##阿曲南#治疗急性细菌性皮肤和皮肤结构#感染#的疗效

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1247605, encodeId=4335124e60542, content=<a href='/topic/show?id=fbd91046826a' target=_blank style='color:#2F92EE;'>#头孢托罗#</a>VS.<a href='/topic/show?id=79b51952ee8' target=_blank style='color:#2F92EE;'>#万古霉素#</a>加<a href='/topic/show?id=dfba104683e4' target=_blank style='color:#2F92EE;'>#阿曲南#</a>治疗急性细菌性皮肤和皮肤结构<a href='/topic/show?id=cfd353291f3' target=_blank style='color:#2F92EE;'>#感染#</a>的疗效, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104682, encryptionId=fbd91046826a, topicName=头孢托罗), TopicDto(id=19527, encryptionId=79b51952ee8, topicName=万古霉素), TopicDto(id=104683, encryptionId=dfba104683e4, topicName=阿曲南), TopicDto(id=53291, encryptionId=cfd353291f3, topicName=感染)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=小小医者, createdTime=Wed Sep 07 03:20:26 CST 2022, time=2022-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013764, encodeId=3e802013e64a2, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Jan 12 06:23:57 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076139, encodeId=759610e6139b9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79b85613715, createdName=快到碗里来, createdTime=Thu Dec 02 10:06:56 CST 2021, time=2021-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459580, encodeId=1002145958063, content=<a href='/topic/show?id=82a24434020' target=_blank style='color:#2F92EE;'>#头孢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44340, encryptionId=82a24434020, topicName=头孢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=acae6165124, createdName=jj000003, createdTime=Wed Dec 01 06:23:57 CST 2021, time=2021-12-01, status=1, ipAttribution=)]
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    2021-12-02 快到碗里来

    学习了

    0

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    2021-12-01 jj000003

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