左房结构或功能异常,增痴呆风险!JAHA研究

2022-08-13 中国循环杂志 中国循环杂志

在排除房颤或脑卒中患者,且考虑了其他血管风险后,那些有心房心肌病患者的痴呆风险仍分别增加31%和28%。

近日发表在《美国心脏协会杂志》上的一项研究表明,左心房结构或功能异常,无论有无症状,或均是痴呆症发生的独立危险因素。

而且在那些即使未发生过房颤或脑卒中者中,这种风险也会增加。

这项研究中,心房心脏病定义为在参与者第五次随访时出现≥1种下列情况:

心电图显示,V1导联 P波终末电势>5000?mV·ms,NT-proBNP >250?pg/mL ,或经胸超声心动图显示左心房容积指数≥34?ml/m2。

研究显示,随访30多年,在人群中,心房心肌病患病率为34%(1709/5078),有763人罹患痴呆症。

心房心肌病患者的痴呆症绝对发病率明显升高(3.69/1000 人年 vs. 1.86/1000 人年)。

进一步分析可见,有心房心肌病者其罹患痴呆风险高出35%。

如果以≥2种上述情况定义心房心肌病(共478例患者),则增加54%的痴呆风险。

在排除房颤或脑卒中患者,且考虑了其他血管风险后,那些有心房心肌病患者的痴呆风险仍分别增加31%和28%。

图1 未校正(A)和校正(B)相关因素后,心房心脏病患者累积无痴呆生存率的Kaplan-Meier 曲线

这项研究分析了社区动脉粥样硬化风险 (ARIC) 研究中5078位参与者的资料,平均年龄为75岁,59%为女性,21%为非裔。

来源:Risk of Dementia Associated With Atrial Cardiopathy: The ARIC Study, Journal of the American Heart Association (2022). DOI: 10.1161/JAHA.121.025646

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    2022-08-15 zhaohui6731
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  4. [GetPortalCommentsPageByObjectIdResponse(id=1914395, encodeId=390119143955d, content=<a href='/topic/show?id=7c90328e6f1' target=_blank style='color:#2F92EE;'>#功能异常#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32876, encryptionId=7c90328e6f1, topicName=功能异常)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Aug 24 18:30:06 CST 2022, time=2022-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268883, encodeId=03411268883c5, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Mon Aug 15 02:30:06 CST 2022, time=2022-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316862, encodeId=19b01316862b2, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Mon Aug 15 02:30:06 CST 2022, time=2022-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247175, encodeId=b8e1124e1756e, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Aug 13 14:30:06 CST 2022, time=2022-08-13, status=1, ipAttribution=)]
    2022-08-13 neuro.Dr

    老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!

    0

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