Clin Cancer Res:18 F-DCFPyL-PET/CT对男性生化复发前列腺癌的诊断表现研究

2021-03-13 AlexYang MedSci原创

目前FDA批准的成像方式不足以定位前列腺癌生化复发(BCR)。18F-DCFPyL是一种高选择性和小分子PSMA靶向的PET放射性示踪剂。

目前FDA批准的成像方式不足以定位前列腺癌生化复发(BCR)。18F-DCFPyL是一种高选择性和小分子PSMA靶向的PET放射性示踪剂。

CONDOR是一项前瞻性研究,旨在确定18F-DCFPyL-PET/CT在BCR和无信息标准成像患者中的表现

研究包括了前列腺切除术后PSA上升{大于或等于}0.2 ng/mL,或放疗后PSA与最低值相比上升{大于或等于}2 ng/mL的男性。主要终点是正确定位率(CLR)。如果3次18F-DCFPyL-PET/CT中有2次CLR的95%置信区间下限超过20%,则认为试验成功。次要终点包括预期治疗的变化和安全性。研究中共有208名基线PSA中位数为0.8 ng/mL(范围:0.2-98.4 ng/mL)的男性接受了18F-DCFPyL-PET/CT检查。CLR为84.8%-87.0%(95%CI的下限:77.8%-80.4%)。63.9%的可评价患者在18F-DCFPyL-PET/CT后改变了预期的治疗方式。疾病检出率为59%-66%(通过18F-DCFPyL-PET/CT检测到每个患者至少一个病灶)。

最后,研究人员指出,18F-DCFPyL-PET/CT的表现达到了研究的主要终点,在阴性标准成像的情况下实现了疾病的定位,并提供了有临床意义和可操作的信息。他们的数据进一步支持了18F-DCFPyL-PET/CT在复发性前列腺癌男性中定位疾病的使用。

原始出处:

Michael J Morris, Steven P Rowe, Michael A Gorin et al. Diagnostic Performance of 18 F-DCFPyL-PET/CT in Men with Biochemically Recurrent Prostate Cancer: Results from the CONDOR Phase 3, Multicenter Study. Clin Cancer Res. Feb 2021

 

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    2021-06-06 feather89
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    2021-03-13 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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