Circ-Heart Fail:咖啡摄入量与心力衰竭风险之间的关联

2021-03-03 MedSci原创 MedSci原创

咖啡摄入量的增加与HF风险降低相关。有必要进行深入研究,以更好地明确咖啡摄入量作为HF潜在可调整危险因素的作用,及其可能的因果关系和潜在机制。

冠心病、心力衰竭(HF)和卒中是具有多种临床表型的复杂疾病。尽管这些疾病的许多危险因素是已知的,但对尚未确定的危险因素进行调查可能会改善这些疾病的风险评估以及患者对预防指南的依从性。

近日,血管领域权威杂志Circ-Heart Fail上发表了一篇研究文章,研究人员对弗莱明翰心脏研究(FHS)、心血管心脏研究(CHS)和社区动脉粥样硬化风险研究(ARIC)中的饮食域进行了调查,以确定与冠心病、HF和卒中相关的潜在生活方式和行为因素。

研究人员使用基于随机森林分析的机器学习功能选择来确定在FHS研究中与冠心病、卒中和HF相关的潜在危险因素。研究人员使用针对已知心血管风险调整后的单变量和多变量Cox比例风险分析评估了所选变量的重要性。并将FHS研究中获得的结果在CHS和ARIC研究中进行验证。

研究人员确定了心血管疾病结局的多种饮食和行为风险因素,包括婚姻状况、红肉、全脂牛奶和咖啡摄入量。在CHS研究(每1杯/天的HR为0.86 [95%CI为0.78–0.96];P=0.005)和ARIC研究(每1杯/天HR为0.98 [95%CI为0.96-0.99];P=0.048)中,咖啡摄入量的增加与HF的长期风险降低相关。根据FHS风险评分进行调整后,CHS研究中的咖啡摄入量仍然与HF显著相关(每1杯/天HR为0.88 [95%CI为0.79–0.97];P=0.01)。

由此可见,在所有三项研究中,咖啡摄入量的增加与HF风险降低相关。有必要进行深入研究,以更好地明确咖啡摄入量作为HF潜在可调整危险因素的作用,及其可能的因果关系和潜在机制

原始出处:

Laura M. Stevens,et al.Association Between Coffee Intake and Incident Heart Failure Risk A Machine Learning Analysis of the FHS, the ARIC Study, and the CHS.Circulation:heart failure. 2021.https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.119.006799

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    2021-04-07 lmm397
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    2021-03-05 ms4305551391379490

    到底是正相关还是负相关

    0

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    2021-03-05 zhaojie88
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    2021-03-05 slcumt
  6. [GetPortalCommentsPageByObjectIdResponse(id=1860689, encodeId=1c39186068946, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Wed Apr 07 07:07:30 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995352, encodeId=e7f6199535253, content=<a href='/topic/show?id=6efb39e7692' target=_blank style='color:#2F92EE;'>#咖啡摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39776, encryptionId=6efb39e7692, topicName=咖啡摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fca128, createdName=licz0423, createdTime=Sun Dec 19 15:07:30 CST 2021, time=2021-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945747, encodeId=8f45945e47f1, content=到底是正相关还是负相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cf011880311, createdName=ms4305551391379490, createdTime=Fri Mar 05 15:43:12 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357661, encodeId=0a6a135e66140, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 05 10:07:30 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563419, encodeId=544d1563419f7, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 05 10:07:30 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945336, encodeId=a2b894533656, content=负相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84f85464656, createdName=ms2000000050996988, createdTime=Thu Mar 04 08:19:08 CST 2021, time=2021-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945261, encodeId=287e945261e1, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=969d2873055, createdName=走,走走, createdTime=Wed Mar 03 22:14:12 CST 2021, time=2021-03-03, status=1, ipAttribution=)]
    2021-03-04 ms2000000050996988

    负相关

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1860689, encodeId=1c39186068946, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Wed Apr 07 07:07:30 CST 2021, time=2021-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995352, encodeId=e7f6199535253, content=<a href='/topic/show?id=6efb39e7692' target=_blank style='color:#2F92EE;'>#咖啡摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39776, encryptionId=6efb39e7692, topicName=咖啡摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fca128, createdName=licz0423, createdTime=Sun Dec 19 15:07:30 CST 2021, time=2021-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945747, encodeId=8f45945e47f1, content=到底是正相关还是负相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cf011880311, createdName=ms4305551391379490, createdTime=Fri Mar 05 15:43:12 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357661, encodeId=0a6a135e66140, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 05 10:07:30 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563419, encodeId=544d1563419f7, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 05 10:07:30 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945336, encodeId=a2b894533656, content=负相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84f85464656, createdName=ms2000000050996988, createdTime=Thu Mar 04 08:19:08 CST 2021, time=2021-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945261, encodeId=287e945261e1, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=969d2873055, createdName=走,走走, createdTime=Wed Mar 03 22:14:12 CST 2021, time=2021-03-03, status=1, ipAttribution=)]
    2021-03-03 走,走走

    有意思

    0

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