Diabetologia:短期力量和平衡训练并不能改善生活质量,但可以改善糖尿病周围神经病变患者的功能状态?

2019-12-28 MedSci MedSci原创

本研究的目的是测试结构性力量和平衡训练干预对改善糖尿病周围神经病变(DPN)患者健康相关生活质量(HRQoL)和功能状态的有效性。

本研究的目的是测试结构性力量和平衡训练干预对改善糖尿病周围神经病变(DPN)患者健康相关生活质量(HRQoL)和功能状态的有效性。

本研究对象为20147月至201710月期间从新加坡5家公共机构招募的2糖尿病和神经病患者。该研究是一项单盲平行组随机对照试验,对2个月每周一次的家庭力量和平衡训练与标准的医疗治疗进行了比较。研究人员将参与者随机分为干预组和对照组。在基线、2个月和6个月时,由一名对分组分配不知情的训练有素的评估人员评估结果。主要结果为SF-36v2(一种36项的HRQoL通用仪器,已在新加坡得到验证)physical component summary (PCS)评分变化和EQ-5D-5L指数评分(超过6个月)。次要结果为功能状态的改变(起跳[TUG]5次坐立[FTSTS]、功能伸展、静态平衡、踝关节肌肉力量和膝关节活动范围)和平衡信心(超过6个月)。使用混合模型比较各组间得分的平均差异。

本研究随机纳入143名参与者(干预,n = 70;对照组(n = 73),每组纳入67名参与者进行最终意向治疗分析。除性别外,这两组参与者组成相似。主要结果PCS评分的组间无显著性差异(mean difference [MD] 1.56 [95% CI−1.75,4.87];p = 0.355)EQ-5D-5L指数评分(MD 0.02 [95% CI−0.01,0.06];p = 0.175)TUG试验性能(MD−1.14 [95% CI−2.18−0.1]s;FTSTS测试性能(MD−1.31 [95% CI−2.12−0.51]s;踝关节肌力(MD 4.18 [95% CI 0.4, 7.92] N;p = 0.031),膝关节活动范围(MD 6.82 [95% CI 2.87, 10.78]°;p = 0.001)和平衡信心评分(MD 6.17 [95% CI 1.89, 10.44];p = 0.005)均有明显改善。整个研究过程没有由于参与研究或研究干预而引起的不良事件报告。

研究结果表明,短期的结构性力量和平衡训练对HRQoL没有影响,但在6个月时产生了功能状态和平衡信心的持续改善。可能需要更深入的干预来影响这些患者的HRQoL。然而,对于DPN患者来说,这种干预可能是一种有效的治疗选择,以减少跌倒和受伤的风险。

原始出处:

Kavita VenkataramanBee Choo TaiShort-term strength and balance training does not improve quality of life but improves functional status in individuals with diabetic peripheral neuropathy: a randomised controlled trial

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    2019-12-28 misszhang

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