NEJM:“麻疹”之旅

2015-06-05 MedSci MedSci原创

一名54的女士作为传教士访问菲律宾后返回美国,随即出现了发热、咳嗽和流鼻涕的症状,持续了5天之久。既往她没有显著的临床病史,不记得自己以往是否有患过麻疹病史。但是,她称在自己小的时候,曾经全面接受过疫苗接种,其中包括麻疹疫苗。但药物的剂量和浓度已不明确。经体格检查发现,她的头部、颈部和肩膀部(如图A所示)等部位均出现了全身弥漫性分布的麻疹。在颊部黏膜上可见有白色的小丘疹(图B所示)。此外,该女士还

一名54的女士作为传教士访问菲律宾后返回美国,随即出现了发热、咳嗽和流鼻涕的症状,持续了5天之久。既往她没有显著的临床病史,不记得自己以往是否有患过麻疹病史。但是,她称在自己小的时候,曾经全面接受过疫苗接种,其中包括麻疹疫苗。但药物的剂量和浓度已不明确。
经体格检查发现,她的头部、颈部和肩膀部(如图A所示)等部位均出现了全身弥漫性分布的麻疹。在颊部黏膜上可见有白色的小丘疹(图B所示)。此外,该女士还出现了颈部淋巴结肿大和结膜炎症状,眼部有浆液性的分泌物渗出(如图C所示)。




实验室检查结果显示,该女士转氨酶升高、白细胞减少和血小板减少。血清学检测结果显示antirubeola IgM抗体滴度升高(为正常上限的4.4倍)和antirubeola IgG抗体滴度降低。根据以上的临床检查结果及其临床表现,高度怀疑其患上的是麻疹,该女士随后立即被进行空气隔离处理。

针对本案例中的患者表现出的麻疹所特有的症状,其又刚从麻疹高发地区旅行归来,即可怀疑其患上的是麻疹,对于麻疹,免疫力低下的人群需要注意保护性的隔离,而正在接种麻疹疫苗的人群也一样。

确诊后,该女士接受了支持性的治疗,大量补充维生素A,不久即康复出院。

原始出处:

Evelyn Lilly, Bhaskar Srivastava.Measles.N Engl J Med 2015; 372:2217June 4, 2015DOI: 10.1056/NEJMicm1407399

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    2015-07-15 皮肤小生

    惊讶同楼上

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=32835, encodeId=3eb932835bf, content=惊讶同楼上, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150715/IMG55A6458618E327245.jpg, createdBy=69501634546, createdName=皮肤小生, createdTime=Wed Jul 15 19:38:00 CST 2015, time=2015-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26732, encodeId=01f226e3202, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Tue Jun 09 19:49:00 CST 2015, time=2015-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355554, encodeId=3bad13555547f, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jun 07 06:18:00 CST 2015, time=2015-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26157, encodeId=cf432615e79, content=为什么人家一个麻疹的报道也能发新英格兰杂志呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jun 06 13:04:00 CST 2015, time=2015-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26139, encodeId=10c0261398b, content=连麻疹的个案都能上NEJM?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c061611816, createdName=sumer, createdTime=Fri Jun 05 23:34:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26134, encodeId=a5fb2613424, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Fri Jun 05 21:04:00 CST 2015, time=2015-06-05, status=1, ipAttribution=)]
    2015-06-09 huaxipanxing

    ?

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=32835, encodeId=3eb932835bf, content=惊讶同楼上, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150715/IMG55A6458618E327245.jpg, createdBy=69501634546, createdName=皮肤小生, createdTime=Wed Jul 15 19:38:00 CST 2015, time=2015-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26732, encodeId=01f226e3202, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Tue Jun 09 19:49:00 CST 2015, time=2015-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355554, encodeId=3bad13555547f, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jun 07 06:18:00 CST 2015, time=2015-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26157, encodeId=cf432615e79, content=为什么人家一个麻疹的报道也能发新英格兰杂志呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jun 06 13:04:00 CST 2015, time=2015-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26139, encodeId=10c0261398b, content=连麻疹的个案都能上NEJM?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c061611816, createdName=sumer, createdTime=Fri Jun 05 23:34:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26134, encodeId=a5fb2613424, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Fri Jun 05 21:04:00 CST 2015, time=2015-06-05, status=1, ipAttribution=)]
    2015-06-07 zhaojie88
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    2015-06-06 lovetcm

    为什么人家一个麻疹的报道也能发新英格兰杂志呢

    0

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    2015-06-05 sumer

    连麻疹的个案都能上NEJM?

    0

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    2015-06-05 s312486

    学到了

    0

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