Alzheimer&Dementia:老年痴呆的遗传易感性会增加中年抑郁症风险!

2022-06-28 MedSci原创 MedSci原创

AD的遗传易感性可能是导致中年抑郁症发病机制的因素之一。

基于社区的前瞻性队列研究发现,抑郁症,无论是中年抑郁症还是晚年抑郁症,都与随后发展为阿尔茨海默病(AD)或血管性痴呆的风险高出2倍有关。晚年抑郁症的前瞻性研究是在大约5万名社区参与者中进行的,研究表明,抑郁症,特别是晚年抑郁症,可能是AD的风险因素或前兆。

尽管抑郁症和较高的AD风险之间存在着既定的联系,但目前还不清楚这两种情况是否有共同的病理生理学。在此,来自美国Emory大学的学者调查了50岁以后出现的抑郁症是否与AD的遗传易感性有关,结果发表在Alzheimer&Dementia杂志。

该研究从以人口为基础的健康和退休研究队列中,通过两年一次的抑郁症状和认知表现的评估,对6656名欧洲血统的人进行了全基因组分型研究。主要估计了AD的多基因风险分数(PRSs),并使用回归模型检查了与认知正常的参与者的抑郁症的关联。

结果显示,在认知正常的参与者中,在考虑到抑郁症的遗传倾向、性别、年龄和教育的影响后,那些抑郁症PRS较高的人在50岁后更可能出现抑郁症(P=6.2×10-11;permuted P=1.0×10-4;GWAS P值阈值=0.0131001;β-系数=5803,N=6656)。

综上,AD的遗传易感性可能是导致中年抑郁症发病机制的因素之一。中年抑郁症和AD之间是否有共同的遗传基础,值得进一步研究。

 

参考文献:

Alzheimer's disease genetic burden is associated with mid-life depression among persons with normal cognition

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    2022-06-23 neuro.Dr

    老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!

    0

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