别再不舍得开空调!Nature最新研究:温度调低,抑制多种癌症生长!还能燃脂减肥

2022-08-08 梅斯头条 MedSci原创

低温疗法对治疗癌症和减肥有很多益处

癌症是一种消耗性疾病,晚期癌症病人经常表现为极度消瘦、形似骷髅。

肿瘤细胞无限制地生长、增殖和转移需要摄取大量的葡萄糖进行有氧糖酵解提供能量。直接阻断糖酵解通路、减少肿瘤细胞的能量供应,不失为一条治疗策略。

但今天要介绍另一种方法,不仅简单、方便、经济实惠(相较药物而言),甚至在家都能完成。

近期发表在《自然》杂志上,来自瑞典卡罗林斯卡学院的华人科学家曹义海教授团队的一项研究证明:通过低温激活体内的棕色脂肪细胞耗能产热,与肿瘤细胞抢夺葡萄糖,使得肿瘤细胞 “无糖可用”,可抑制多种肿瘤生长,延长患癌小鼠生存期,人体试验中,22℃的低温疗法同样展现了其治疗潜力。(转发至家族群,配文:不是谣言!科学家发现开空调能够治疗癌症!)

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皮下移植了结直肠癌肿瘤细胞的小鼠,分别置于30℃和4℃的环境中,和30℃环境下的肿瘤小鼠相比,4℃环境下的小鼠,肿瘤生长速度明显被抑制,肿瘤组织内增殖的细胞占比更低,肿瘤小鼠总生存期翻倍。

图片

除了结直肠癌,在其它的癌症类型包括纤维肉瘤、乳腺癌、黑色素瘤,甚至是“癌中之王”胰腺癌的小鼠身上,低温都能够抑制这些肿瘤生长,说明“低温疗法”适用于多种癌症。

要证明低温状态激发棕色脂肪组织与肿瘤细胞争夺葡萄糖,最直接的方法就是利用PET-CT显示小鼠体内葡萄糖的去向,可以看到,4℃的环境下,葡萄糖大量聚集在小鼠棕色脂肪区域,而肿瘤区域的葡萄糖摄取则显著下降。

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不仅如此,在低温状态下,小鼠肿瘤组织中糖酵解相关的代谢产物减少,而棕色脂肪组织中糖酵解相关代谢产物增多、脂肪组织呈现出小的多房结构、线粒体含量及微血管密度增加的激活表现,进一步说明了低温时,棕色脂肪组织激活,能够与肿瘤组织争夺葡萄糖,抑制肿瘤细胞糖酵解产能。

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当肿瘤小鼠的棕色脂肪组织被切除,或去除对于棕色脂肪产热至关重要的UCP1基因时,低温抑制肿瘤生长的效果消失,证实低温抑癌关键在于棕色脂肪产热。

又或者在低温治疗时,给肿瘤小鼠补充15%的葡萄糖溶液,此时棕色脂肪虽然也在孜孜不断摄取葡萄糖,但在葡萄糖供过于求的情况下,肿瘤组织也分到了一杯羹,低温抑癌失败,再次强调了限制肿瘤细胞摄取葡萄糖,“不能让肿瘤组织尝到一点甜头”的重要性。(吹空调还要管住嘴)

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最后,也是大家最关心的问题,“低温疗法”能不能用到人身上?研究人员初步进行了小小的人体试验尝试,募集了6名身体健康的22-25岁男性和女性,以及1名经历了化疗的18岁霍奇金淋巴瘤患者。

6名健康成人身着T恤、短裤,呆在16℃的环境中每天2-6小时,持续14天,PET-CT显示这些年轻人颈部、胸骨旁区域以及双侧锁骨上的棕色脂肪正在“燃烧”,虽然每个人脂肪燃烧的程度还存在着一些个体差异,不过这至少也说明了16℃就能使健康成人棕色脂肪激活(还好不是4℃)。

图片

而在唯一的一名癌症患者身上,研究人员对其进行的是为期7天、22℃的更加温和的“低温治疗”,结果还是比较鼓舞人心的:这名患者棕色脂肪区域激活,摄取葡萄糖增加,而纵膈淋巴瘤部位的葡萄糖信号显著降低。

图片

总的来说,在一个大多数人可以耐受的低温环境(比如22℃),激活棕色脂肪组织抢夺肿瘤的葡萄糖,减少肿瘤能量供应,从而抑制肿瘤生长,目前看来,可能是一种很有前途的癌症治疗新方法,但还需要在更大规模的临床研究中进行验证。

看了这篇研究之后,再面对夏天的电费刺客,感觉有被安慰到(咱开空调不为治疗癌症,就想燃烧一下脂肪)。

参考文献:

[1]Seki T, Yang Y, Sun X, et al. Brown-fat-mediated tumour suppression by cold-altered global metabolism [published online ahead of print, 2022 Aug 3]. Nature. 2022;10.1038/s41586-022-05030-3. doi:10.1038/s41586-022-05030-3

撰文 | 四五七
编辑 | 阿拉斯加宝

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    2023-03-22 liye789132251
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    2022-10-16 12186135m89(暂无昵称)

    用PET评价棕色脂肪,尤其是用PET得出“棕色脂肪高摄取时的纵隔淋巴结摄取变低”的结论是有问题的。

    0

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    2022-08-16 贵阳
  4. [GetPortalCommentsPageByObjectIdResponse(id=1885926, encodeId=061d1885926fc, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Mar 22 10:36:10 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2093992, encodeId=455e20939925d, content=用PET评价棕色脂肪,尤其是用PET得出“棕色脂肪高摄取时的纵隔淋巴结摄取变低”的结论是有问题的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8a52261621, createdName=12186135m89(暂无昵称), createdTime=Sun Oct 16 00:28:11 CST 2022, time=2022-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736512, encodeId=fe9c1e3651226, content=<a href='/topic/show?id=a421604e721' target=_blank style='color:#2F92EE;'>#最新#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60477, encryptionId=a421604e721, topicName=最新)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4bd534165494, createdName=贵阳, createdTime=Tue Aug 16 07:36:10 CST 2022, time=2022-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237572, encodeId=5058123e572ad, content=学习了,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bcd35483456, createdName=ms4000001452516490, createdTime=Tue Aug 09 14:22:21 CST 2022, time=2022-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237404, encodeId=5415123e40418, content=冬天会有效吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96198245009, createdName=ms3000001153881213, createdTime=Mon Aug 08 16:53:54 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237297, encodeId=0d4c123e2978a, content=有没有所有寒带国家相同年龄段性别下,癌症发病率比热带国家低的研究数据?, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230412/7f4409075a2847aea5d6fdb1ed77e1c1/afb81e82b8894278bf02e15e5c56100f.jpg, createdBy=8bba6454600, createdName=ms3000000123620759, createdTime=Mon Aug 08 11:26:57 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237190, encodeId=f498123e1907b, content=哈哈哈好消息, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Mon Aug 08 08:25:32 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237189, encodeId=f24b123e189f0, content=这样算下来靠近南北极国家的人天然就比赤道附近国家的人有优势。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=49278254559, createdName=ms4000000559567758, createdTime=Mon Aug 08 08:23:07 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1245954, encodeId=4c2c12459547f, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Mon Aug 08 02:36:10 CST 2022, time=2022-08-08, status=1, ipAttribution=)]
    2022-08-09 ms4000001452516490

    学习了,谢谢!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1885926, encodeId=061d1885926fc, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Mar 22 10:36:10 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2093992, encodeId=455e20939925d, content=用PET评价棕色脂肪,尤其是用PET得出“棕色脂肪高摄取时的纵隔淋巴结摄取变低”的结论是有问题的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8a52261621, createdName=12186135m89(暂无昵称), createdTime=Sun Oct 16 00:28:11 CST 2022, time=2022-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736512, encodeId=fe9c1e3651226, content=<a href='/topic/show?id=a421604e721' target=_blank style='color:#2F92EE;'>#最新#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60477, encryptionId=a421604e721, topicName=最新)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4bd534165494, createdName=贵阳, createdTime=Tue Aug 16 07:36:10 CST 2022, time=2022-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237572, encodeId=5058123e572ad, content=学习了,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bcd35483456, createdName=ms4000001452516490, createdTime=Tue Aug 09 14:22:21 CST 2022, time=2022-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237404, encodeId=5415123e40418, content=冬天会有效吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96198245009, createdName=ms3000001153881213, createdTime=Mon Aug 08 16:53:54 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237297, encodeId=0d4c123e2978a, content=有没有所有寒带国家相同年龄段性别下,癌症发病率比热带国家低的研究数据?, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230412/7f4409075a2847aea5d6fdb1ed77e1c1/afb81e82b8894278bf02e15e5c56100f.jpg, createdBy=8bba6454600, createdName=ms3000000123620759, createdTime=Mon Aug 08 11:26:57 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237190, encodeId=f498123e1907b, content=哈哈哈好消息, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Mon Aug 08 08:25:32 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237189, encodeId=f24b123e189f0, content=这样算下来靠近南北极国家的人天然就比赤道附近国家的人有优势。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=49278254559, createdName=ms4000000559567758, createdTime=Mon Aug 08 08:23:07 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1245954, encodeId=4c2c12459547f, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Mon Aug 08 02:36:10 CST 2022, time=2022-08-08, status=1, ipAttribution=)]
    2022-08-08 ms3000001153881213

    冬天会有效吗

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1885926, encodeId=061d1885926fc, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Mar 22 10:36:10 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2093992, encodeId=455e20939925d, content=用PET评价棕色脂肪,尤其是用PET得出“棕色脂肪高摄取时的纵隔淋巴结摄取变低”的结论是有问题的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8a52261621, createdName=12186135m89(暂无昵称), createdTime=Sun Oct 16 00:28:11 CST 2022, time=2022-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736512, encodeId=fe9c1e3651226, content=<a href='/topic/show?id=a421604e721' target=_blank style='color:#2F92EE;'>#最新#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60477, encryptionId=a421604e721, topicName=最新)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4bd534165494, createdName=贵阳, createdTime=Tue Aug 16 07:36:10 CST 2022, time=2022-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237572, encodeId=5058123e572ad, content=学习了,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bcd35483456, createdName=ms4000001452516490, createdTime=Tue Aug 09 14:22:21 CST 2022, time=2022-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237404, encodeId=5415123e40418, content=冬天会有效吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96198245009, createdName=ms3000001153881213, createdTime=Mon Aug 08 16:53:54 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237297, encodeId=0d4c123e2978a, content=有没有所有寒带国家相同年龄段性别下,癌症发病率比热带国家低的研究数据?, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230412/7f4409075a2847aea5d6fdb1ed77e1c1/afb81e82b8894278bf02e15e5c56100f.jpg, createdBy=8bba6454600, createdName=ms3000000123620759, createdTime=Mon Aug 08 11:26:57 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237190, encodeId=f498123e1907b, content=哈哈哈好消息, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Mon Aug 08 08:25:32 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237189, encodeId=f24b123e189f0, content=这样算下来靠近南北极国家的人天然就比赤道附近国家的人有优势。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=49278254559, createdName=ms4000000559567758, createdTime=Mon Aug 08 08:23:07 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1245954, encodeId=4c2c12459547f, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Mon Aug 08 02:36:10 CST 2022, time=2022-08-08, status=1, ipAttribution=)]
    2022-08-08 ms3000000123620759

    有没有所有寒带国家相同年龄段性别下,癌症发病率比热带国家低的研究数据?

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1885926, encodeId=061d1885926fc, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Mar 22 10:36:10 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2093992, encodeId=455e20939925d, content=用PET评价棕色脂肪,尤其是用PET得出“棕色脂肪高摄取时的纵隔淋巴结摄取变低”的结论是有问题的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8a52261621, createdName=12186135m89(暂无昵称), createdTime=Sun Oct 16 00:28:11 CST 2022, time=2022-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736512, encodeId=fe9c1e3651226, content=<a href='/topic/show?id=a421604e721' target=_blank style='color:#2F92EE;'>#最新#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60477, encryptionId=a421604e721, topicName=最新)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4bd534165494, createdName=贵阳, createdTime=Tue Aug 16 07:36:10 CST 2022, time=2022-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237572, encodeId=5058123e572ad, content=学习了,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bcd35483456, createdName=ms4000001452516490, createdTime=Tue Aug 09 14:22:21 CST 2022, time=2022-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237404, encodeId=5415123e40418, content=冬天会有效吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96198245009, createdName=ms3000001153881213, createdTime=Mon Aug 08 16:53:54 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237297, encodeId=0d4c123e2978a, content=有没有所有寒带国家相同年龄段性别下,癌症发病率比热带国家低的研究数据?, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230412/7f4409075a2847aea5d6fdb1ed77e1c1/afb81e82b8894278bf02e15e5c56100f.jpg, createdBy=8bba6454600, createdName=ms3000000123620759, createdTime=Mon Aug 08 11:26:57 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237190, encodeId=f498123e1907b, content=哈哈哈好消息, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Mon Aug 08 08:25:32 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237189, encodeId=f24b123e189f0, content=这样算下来靠近南北极国家的人天然就比赤道附近国家的人有优势。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=49278254559, createdName=ms4000000559567758, createdTime=Mon Aug 08 08:23:07 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1245954, encodeId=4c2c12459547f, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Mon Aug 08 02:36:10 CST 2022, time=2022-08-08, status=1, ipAttribution=)]
    2022-08-08 carrotlyl

    哈哈哈好消息

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1885926, encodeId=061d1885926fc, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Mar 22 10:36:10 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2093992, encodeId=455e20939925d, content=用PET评价棕色脂肪,尤其是用PET得出“棕色脂肪高摄取时的纵隔淋巴结摄取变低”的结论是有问题的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8a52261621, createdName=12186135m89(暂无昵称), createdTime=Sun Oct 16 00:28:11 CST 2022, time=2022-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736512, encodeId=fe9c1e3651226, content=<a href='/topic/show?id=a421604e721' target=_blank style='color:#2F92EE;'>#最新#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60477, encryptionId=a421604e721, topicName=最新)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4bd534165494, createdName=贵阳, createdTime=Tue Aug 16 07:36:10 CST 2022, time=2022-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237572, encodeId=5058123e572ad, content=学习了,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bcd35483456, createdName=ms4000001452516490, createdTime=Tue Aug 09 14:22:21 CST 2022, time=2022-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237404, encodeId=5415123e40418, content=冬天会有效吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96198245009, createdName=ms3000001153881213, createdTime=Mon Aug 08 16:53:54 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237297, encodeId=0d4c123e2978a, content=有没有所有寒带国家相同年龄段性别下,癌症发病率比热带国家低的研究数据?, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230412/7f4409075a2847aea5d6fdb1ed77e1c1/afb81e82b8894278bf02e15e5c56100f.jpg, createdBy=8bba6454600, createdName=ms3000000123620759, createdTime=Mon Aug 08 11:26:57 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237190, encodeId=f498123e1907b, content=哈哈哈好消息, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Mon Aug 08 08:25:32 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237189, encodeId=f24b123e189f0, content=这样算下来靠近南北极国家的人天然就比赤道附近国家的人有优势。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=49278254559, createdName=ms4000000559567758, createdTime=Mon Aug 08 08:23:07 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1245954, encodeId=4c2c12459547f, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Mon Aug 08 02:36:10 CST 2022, time=2022-08-08, status=1, ipAttribution=)]
    2022-08-08 ms4000000559567758

    这样算下来靠近南北极国家的人天然就比赤道附近国家的人有优势。

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1885926, encodeId=061d1885926fc, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Mar 22 10:36:10 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2093992, encodeId=455e20939925d, content=用PET评价棕色脂肪,尤其是用PET得出“棕色脂肪高摄取时的纵隔淋巴结摄取变低”的结论是有问题的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8a52261621, createdName=12186135m89(暂无昵称), createdTime=Sun Oct 16 00:28:11 CST 2022, time=2022-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736512, encodeId=fe9c1e3651226, content=<a href='/topic/show?id=a421604e721' target=_blank style='color:#2F92EE;'>#最新#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60477, encryptionId=a421604e721, topicName=最新)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4bd534165494, createdName=贵阳, createdTime=Tue Aug 16 07:36:10 CST 2022, time=2022-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237572, encodeId=5058123e572ad, content=学习了,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bcd35483456, createdName=ms4000001452516490, createdTime=Tue Aug 09 14:22:21 CST 2022, time=2022-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237404, encodeId=5415123e40418, content=冬天会有效吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96198245009, createdName=ms3000001153881213, createdTime=Mon Aug 08 16:53:54 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237297, encodeId=0d4c123e2978a, content=有没有所有寒带国家相同年龄段性别下,癌症发病率比热带国家低的研究数据?, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230412/7f4409075a2847aea5d6fdb1ed77e1c1/afb81e82b8894278bf02e15e5c56100f.jpg, createdBy=8bba6454600, createdName=ms3000000123620759, createdTime=Mon Aug 08 11:26:57 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237190, encodeId=f498123e1907b, content=哈哈哈好消息, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Mon Aug 08 08:25:32 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1237189, encodeId=f24b123e189f0, content=这样算下来靠近南北极国家的人天然就比赤道附近国家的人有优势。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=49278254559, createdName=ms4000000559567758, createdTime=Mon Aug 08 08:23:07 CST 2022, time=2022-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1245954, encodeId=4c2c12459547f, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Mon Aug 08 02:36:10 CST 2022, time=2022-08-08, status=1, ipAttribution=)]
    2022-08-08 CHANGE

    什么时候有懒人用的减肥神药?

    0