Hypertension:无论什么年龄,只要血压高就能加速认知功能下降

2020-12-21 MedSci原创 MedSci原创

尽管药物治疗已取得长足进展,高血压仍是全球早死的主要原因。近期研究发现,患高血压会对认知功能的减退起到加速作用,并且与患者的年龄无关。预防高血压不再是老年人的话题,而应当成为所有人警惕和关注的问题。

尽管药物治疗已取得长足进展,高血压仍是全球早死的主要原因。根据Lancet发布的一项研究报告显示,1975至到2015年,全球饱受高血压之苦的人数从5.94亿增至11亿。其中,2.26亿高血压患者生活在中国。众所周知,高血压与认知功能减退有关,但高血压在不同发病年龄段、患病时间以及血压控制等对认知功能的影响之间差别尚无定论。近日,发表在Hypertension杂志的一项研究显示,无论什么年龄患高血压,无论患病时间多长,都可能会加速认知功能的减退。

在这项研究中,研究人员收纳了来自成人健康纵向研究(ELSA-Brasil)2008年到2010年7063名参与者信息,平均年龄58.9岁。在基线和2012年到2014年间,参与者接受了2次认知功能评估,包括记忆力、语言流畅性、反应速度、注意力等指标。在本研究中,研究人员将收缩压≤120mmHg,舒张压≤80mmHg且未服用降压药的人群被视为血压正常;将收缩压为120mmHg到139mmHg,或舒张压为80mmHg到89mmHg,且未服用降压药,血压偏高,被认为高血压前期;将收缩压≥140 mmHg或舒张压≥90 mmHg,或正在服用降压药定义为高血压。通过分析高血压、高血压前期、年龄段、诊断时间以及血压控制情况,对认知功能的影响。

在平均随访4年后,研究人员发现,在未使用降压药的情况下,收缩压在121至139 mmHg之间或舒张压在81至89 mmHg之间与中老年人的认知能力下降有关。与控制高血压的成年人相比,不受控制的高血压患者的记忆力和整体认知功能下降的趋势明显更快。另外,不论高血压持续时间长短,认知下降的速度都会发生,这意味着在任何时间段(甚至持续时间很短)内的高血压都可能影响认知下降。此外,研究结果强调,及时诊断和控制高血压,是预防或减缓认知功能下降的重要手段。

总体来说,只要患有高血压,不论什么年龄,都在不同程度上使得认知功能下降,即使是高血压前期。而且高血压、高血压前期和血压控制情况,均是认知功能下降的不同独立预测因子。


原始出处

Sara Teles de Menezes , Luana Giatti , Luisa Campos Caldeira Brant, Rosane Harter Griep.et al.Hypertension, Prehypertension, and Hypertension Control Association With Decline in Cognitive Performance in the ELSA-Brasil Cohort.Hypertension.2020

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    2021-05-16 feather89
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  5. [GetPortalCommentsPageByObjectIdResponse(id=2034335, encodeId=4cd5203433529, content=<a href='/topic/show?id=2fda91215d2' target=_blank style='color:#2F92EE;'>#认知功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91215, encryptionId=2fda91215d2, topicName=认知功能下降)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Sat Feb 27 11:53:45 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039230, encodeId=52302039230a2, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Tue May 18 00:53:45 CST 2021, time=2021-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728745, encodeId=bad11e287453b, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun May 16 09:53:45 CST 2021, time=2021-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501507, encodeId=1ab7150150e67, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Wed Dec 23 08:53:45 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910230, encodeId=b36c91023046, content=年轻人,也要做好血压管理, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Tue Dec 22 23:02:46 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910091, encodeId=179a910091b9, content=一定要重视血压,不要有高血压!<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Dec 22 15:19:21 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909914, encodeId=b2bf9099148f, content=所以保持血压正常是保证认知水平的前提, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200901/629d1ce7d6f64d17a642c37c90dea72c/202f9333a3ea4b23a9b07ede3364e86b.jpg, createdBy=1a335163906, createdName=Sunny orchard, createdTime=Mon Dec 21 23:08:50 CST 2020, time=2020-12-21, status=1, ipAttribution=)]
    2020-12-22 rayms

    年轻人,也要做好血压管理

    0

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    2020-12-22 Jessica

    一定要重视血压,不要有高血压!#高血压#

    0

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    2020-12-21 Sunny orchard

    所以保持血压正常是保证认知水平的前提

    0

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