Brit J Cancer:新型尿蛋白生物标志物组可早期诊断胃癌

2020-09-16 网络 网络

新型尿蛋白生物标记物是包括早期疾病在内的有前景的GC无创生物标记物。

为了发现早期诊断胃癌(GC)的无创生物标记物,近日,肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章。研究人员进行了一项病例对照研究,旨在利用早期GC与健康对照(HC)者的尿液样本进行对比。

372位GC患者和年龄与性别相匹配的282位HC者被随机分为三组:发现队列有的18名患者;训练队列有176名患者和验证队列有88名患者。

在尿蛋白中进行全面定量蛋白质组学分析,除幽门螺杆菌状态外,尿液中TFF1(uTFF1)和ADAM12(uADAM12)的水平是GC的重要独立诊断标志物。在训练和验证队列中,联合了uTFF1、uADAM12和幽门螺杆菌的尿液生物标志物组可显著区分HC和GC患者。

在性别特异性生物标志物的分析中,该联合组对于男性GC诊断的AUC为0.858,而uTFF1、uBARD1和幽门螺杆菌的组合对于女性GC诊断AUC为0.893。值得注意的是,每个组合甚至可以区分I期GC患者和HC患者(男性AUC=0.850;女性AUC=0.845)。

由此可见,新型尿蛋白生物标记物是包括早期疾病在内的有前景的GC无创生物标记物。

原始出处:

Takaya Shimura.et al.Novel urinary protein biomarker panel for early diagnosis of gastric cancer.British Journal of Cancer.2020.https://www.nature.com/articles/s41416-020-01063-5

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    2020-10-27 lovetcm

    #胃癌##代谢组学##蛋白质组学#,很难实际应用起来

    0

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  4. 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  5. 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  6. 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  7. [GetPortalCommentsPageByObjectIdResponse(id=1841573, encodeId=22ae18415e377, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Wed Mar 10 18:20:21 CST 2021, time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894874, encodeId=79d98948e48e, content=<a href='/topic/show?id=f9e2832202f' target=_blank style='color:#2F92EE;'>#胃癌#</a>用<a href='/topic/show?id=0a66254e002' target=_blank style='color:#2F92EE;'>#代谢组学#</a>或<a href='/topic/show?id=915d88e3471' target=_blank style='color:#2F92EE;'>#蛋白质组学#</a>,很难实际应用起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=192, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83220, encryptionId=f9e2832202f, topicName=胃癌), TopicDto(id=25470, encryptionId=0a66254e002, topicName=代谢组学), TopicDto(id=88734, encryptionId=915d88e3471, topicName=蛋白质组学)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Oct 27 17:15:33 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332296, encodeId=86bc13322965f, content=<a href='/topic/show?id=33994e50466' target=_blank style='color:#2F92EE;'>#尿蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47504, encryptionId=33994e50466, topicName=尿蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dca2500075, createdName=396094184_42047355, createdTime=Fri Sep 18 03:20:21 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382708, encodeId=26f01382e08bc, content=<a href='/topic/show?id=1f4e5946422' target=_blank style='color:#2F92EE;'>#早期诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59464, encryptionId=1f4e5946422, topicName=早期诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=71f1477, createdName=s_pl2008, createdTime=Fri Sep 18 03:20:21 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560955, encodeId=0f1e1560955dd, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Sep 18 03:20:21 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566964, encodeId=0e77156696435, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Sep 18 03:20:21 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=885829, encodeId=d954885829d3, content=hah a, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8955418722, createdName=ms3000001672435237, createdTime=Wed Sep 16 17:46:17 CST 2020, time=2020-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=885922, encodeId=34e188592259, content=早期诊断真的很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200912/b6f9fd0c92f041fb87d7e5df3981cac6/ebaa3e1fcb174de291f5f06daf872739.jpg, createdBy=dab05329240, createdName=SASORIxxxx, createdTime=Wed Sep 16 23:00:46 CST 2020, time=2020-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=885885, encodeId=051b88588545, content=新型<a href='/topic/show?id=37d4103915a0' target=_blank style='color:#2F92EE;'>#尿蛋白生物标记物#</a>是<a href='/topic/show?id=16ff59446af' target=_blank style='color:#2F92EE;'>#早期胃癌#</a>的无创生物标记物。这个很好! , beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103915, encryptionId=37d4103915a0, topicName=尿蛋白生物标记物), TopicDto(id=59446, encryptionId=16ff59446af, topicName=早期胃癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Sep 16 21:25:23 CST 2020, time=2020-09-16, status=1, ipAttribution=)]
    2020-09-16 ms3000001672435237

    hah a

    0

  8. 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, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103915, encryptionId=37d4103915a0, topicName=尿蛋白生物标记物), TopicDto(id=59446, encryptionId=16ff59446af, topicName=早期胃癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Sep 16 21:25:23 CST 2020, time=2020-09-16, status=1, ipAttribution=)]
    2020-09-16 SASORIxxxx

    早期诊断真的很重要

    0

  9. 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, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103915, encryptionId=37d4103915a0, topicName=尿蛋白生物标记物), TopicDto(id=59446, encryptionId=16ff59446af, topicName=早期胃癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Sep 16 21:25:23 CST 2020, time=2020-09-16, status=1, ipAttribution=)]
    2020-09-16 Jessica

    新型#尿蛋白生物标记物##早期胃癌#的无创生物标记物。这个很好!

    0

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