JNNP:家族性额颞部痴呆神经炎症的活体PET显像

2020-11-22 MedSci原创 MedSci原创

五分之一的额颞叶性痴呆(FTD)病例为常染色体显性遗传,最常见于MAPT、GRN或C9orf72基因突变。家族性FTD的病理和临床特征与散发病例非常相似,但突变携带者允许推断潜在病理学的分子特异性。虽

五分之一的额颞叶性痴呆(FTD)病例为常染色体显性遗传,最常见于MAPT、GRN或C9orf72基因突变。家族性FTD的病理和临床特征与散发病例非常相似,但突变携带者允许推断潜在病理学的分子特异性。虽然tau或TDP-43(蛋白的错误折叠和聚集导致了典型的FTD神经病理学,但神经炎可能是一个早期的致病过程,而不是神经退行性变的结果。这一假设得到全基因组关联研究的支持,这些研究涉及FTD,3中的免疫途径,以及动物研究,这些研究确定了tau积累之前的炎症变化。作者报告了7例家族性额颞叶痴呆(FTD)患者的神经炎症和异常蛋白聚集模式,使用[11C]PK11195来量化MAPT、GRN或C9orf72突变的有症状家族性FTD患者的体内神经炎症。然后比较了炎症的分布和[18F]AV-1451结合的分布。

方法:从剑桥大学额颞部痴呆中心招募了7例家族性FTD患者:2例MAPT基因突变,2例GRN和3例C9orf72扩增。6名患者符合行为变异性FTD(bvFTD)的诊断标准。1名患者符合非流利变异性原发性进行性失语症(nfvPPA)的诊断标准。应用正电子发射断层扫描(PET)技术,探讨放射性配体[11C]PK11195测量的活化小胶质细胞分布与tau或TDP-43病理学区域分布的相关性,并用放射性配体[18F]AV-1451进行注射检查。家庭FTD-PET数据与健康对照组比较。

结果:所有突变组中家族性FTD患者的[11C]PK11195结合增加主要发生在额颞叶区域,其他区域则表现为个体异常。MAPT突变患者的[18F]AV-1451结合在整个大脑中的分布是一致的,在GRN和C9orf72突变携带者之间分布不均匀。

讨论:这一系列病例表明神经炎症是家族性FTD病理生理学的一部分,因此需要进一步考虑免疫调节疗法来改变和预防疾病。

Malpetti MRittman TJones PS, et al In vivo PET imaging of neuroinflammation in familial frontotemporal dementia

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    2021-06-02 feather89
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    2020-12-03 1341ffcd52m

    学习

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1717520, encodeId=28c51e1752049, content=<a href='/topic/show?id=1a47e436211' target=_blank style='color:#2F92EE;'>#神经炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74362, encryptionId=1a47e436211, topicName=神经炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=662f32423113, createdName=liye789132262, createdTime=Sun Sep 26 18:21:12 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728723, encodeId=7bc81e287233e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Jun 02 15:21:12 CST 2021, time=2021-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904612, encodeId=58a590461222, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201105/955e25d151f04dcc890fb972d32943d4/e774c2ca032f404b997220611a7a6c17.jpg, createdBy=8a152145515, createdName=1341ffcd52m, createdTime=Thu Dec 03 15:58:43 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331167, encodeId=de7c133116ea4, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Tue Nov 24 08:21:12 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629584, encodeId=19691629584a0, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26fc21339997, createdName=wetgdt, createdTime=Tue Nov 24 08:21:12 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901531, encodeId=27a490153162, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d86e1299318, createdName=911524993, createdTime=Mon Nov 23 19:27:34 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901284, encodeId=4ac5901284dc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b4b4230603, createdName=13df4a40m17暂无昵称, createdTime=Sun Nov 22 21:56:21 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048688, encodeId=c45010486887f, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sun Nov 22 20:21:12 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901246, encodeId=6a589012467e, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoIpjT9rusL9u93rJvkVShGeoZEj0I1HQ2FNloXibKyicHnFj0cfQSxXgTXyzia9fQxkmkyZGBFFdqJQ/0, createdBy=63d22215150, createdName=mayue8866, createdTime=Sun Nov 22 18:34:33 CST 2020, time=2020-11-22, status=1, ipAttribution=)]
    2020-11-24 wetgdt
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    2020-11-23 911524993

    学习

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    2020-11-22 13df4a40m17暂无昵称

    学习了

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    2020-11-22 junJUN

    老年人痴呆何药可用??

    0

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    2020-11-22 mayue8866

    值得学习

    0

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