Diabetologia |哈佛研究:坚持吃草,尤其是健康的植物性饮食能明显降低2型糖尿病的风险

2022-04-23 网络 网络

以植物为基础的饮食,特别是富含健康植物食物的饮食,与2型糖尿病的风险较低有关

以植物为基础的饮食,特别是富含健康植物食物的饮食,与2型糖尿病的风险较低有关。然而,与植物性饮食相关的血浆代谢物谱是否反映了这种关联尚不清楚。为了确定与植物性饮食相关的血浆代谢物谱,并评估所确定的代谢物谱与2型糖尿病风险之间的关联,来自哈佛大学的学者开展了相关研究,结果发表在Diabetologia杂志上。

在三个前瞻性队列(护士健康研究、护士健康研究II和卫生专业人员随访研究)中,研究人员使用高通量LCMS测量了10684名参与者的血浆代谢物。对植物性饮食的坚持是通过食物频率调查表得出的三个指数来评估的:总体植物性饮食指数(PDI)、健康植物性饮食指数(hPDI)和不健康植物性饮食指数(uPDI)。

结果共确定了包括55个PDI的代谢物、93个hPDI的代谢物和75个uPDI的代谢物的多代谢物。基于所鉴定的代谢物谱的得分与相应的饮食指数相关(Pearson r = 0.33-0.35,PDI为0.41-0.45,uPDI为0.37-0.38,均为p<0.001)。

总的来说,PDI的代谢物谱得分(每提高1SD,风险降低19%,HR=0.81[95% CI 0.75, 0.88])和hPDI(每提高1SD,风险降低23%,HR=0.77[95% CI 0.71, 0.84])与发生2型糖尿病呈反向关系,而uPDI的代谢物谱得分与风险没有关系。

对代谢物谱中所选择的代谢物,包括三甘醇、海马酸、异亮氨酸和三酰甘油的一个子集进行相互调整,削弱了饮食指数PDI和hPDI与较低的2型糖尿病风险的关联。这些代谢物可解释的PDI/hPDI相关的糖尿病风险比例在8.5%和37.2%之间(所有P<0.05)。

综上,与植物性饮食有关的血浆代谢物,特别是健康的植物性饮食,与一般健康人群中较低的2型糖尿病风险有关。

 

参考文献:

Plasma metabolite profiles related to plant-based diets and the risk of type 2 diabetes. Diabetologia (2022). https://doi.org/10.1007/s00125-022-05692-8

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    2022-06-18 xuyong535
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    2023-01-20 docwu2019
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    2022-06-23 1245455dm62暂无昵称

    健康的植物性饮食,有吗

    0

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    2022-04-24 ms1000001822049992

    学到了

    0

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    2022-04-15 amyloid

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