Plos One:十年间,中国心肌梗死后使用心血管药物二次预防现状调查

2017-04-22 MedSci MedSci原创

目前,中国的心肌梗塞(MI)已成为患者发病和死亡的主要原因,但在过去二十年,MI事件发生后推荐的心血管药物使用情况知之甚少。近期,一项发表在杂志Plos One上的研究系统性评价了1995 - 2015年之间的心血管药物使用情况,并评估了与心血管药物趋势相关的因素。研究者们在四个数据库(Pubmed,Embase,CENTRAL和CNKI)中进行了系统的检索,以获得1995年至2015年间发表的观

目前,中国的心肌梗塞(MI)已成为患者发病和死亡的主要原因,但在过去二十年,MI事件发生后推荐的心血管药物使用情况知之甚少。


近期,一项发表在杂志Plos One上的研究系统性评价了1995 - 2015年之间的心血管药物使用情况,并评估了与心血管药物趋势相关的因素。

研究者们在四个数据库(Pubmed,Embase,CENTRAL和CNKI)中进行了系统的检索,以获得1995年至2015年间发表的观察性研究报告,报告了中国心血管药物的使用情况。对个别研究的偏见风险进行了评估,并对心血管药物的估计流行率进行了选择性研究。通过随机效应元回归模型估计1995年和2015年心血管药物使用率。

最终,确定了13940份出版物,其中包括28,000名患者的35项研究。阿司匹林、β-阻滞剂、他汀类药物、ACE抑制剂、ACE抑制剂/ ARBs以及硝酸盐的汇总使用情况分别为92%[95%置信区间(CI):0.89-0.95],63%(95%CI:0.57-0.69 ),72%(95%CI:0.60-0.82),49%(95%CI:0.41-0.57),59%(95%CI:0.48-0.69)和79%(95%CI:0.74-0.91)。

随着时间的推移,观察到β受体阻滞剂和他汀类药物使用量的显着增加,以及硝酸盐类药物使用量的下降。 2015年,β-阻滞剂、他汀类药物和硝酸盐类药物的估计使用情况分别为78%、91.1%和59.3%,而1995年分别为32%、17%和96%。

此项研究结果表明:尽管1995-2015年期间其使用率普遍上升,但是心脏梗死后心血管药物的使用在中国患者中远未达到最佳水平。随着中国MI患者人数的迅速增加,二级预防的综合战略是有必要的。

原始出处:
Zhao M, Klipstein-Grobusch K, et al. Prevalence of cardiovascular medication on secondary prevention after myocardial infarction in China between 1995-2015: A systematic review and meta-analysis. PLoS One. 2017 Apr 20;12(4):e0175947. doi: 10.1371/journal.pone.0175947. eCollection 2017.

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    2017-04-27 大爰

    学习了增加知识了分享了谢谢

    0

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    2017-04-25 ylzr123

    认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。点赞啦!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1789944, encodeId=43341e89944a7, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Wed Feb 28 23:36:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1646033, encodeId=54bd164603385, content=<a href='/topic/show?id=470051898b0' target=_blank style='color:#2F92EE;'>#心血管药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51898, encryptionId=470051898b0, topicName=心血管药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8b223291988, createdName=jiafufeng@yaho, createdTime=Mon Dec 11 06:36:00 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190961, encodeId=662719096101, content=学习了增加知识了分享了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Apr 27 06:24:57 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190333, encodeId=4f751903334d, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。点赞啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Apr 25 05:33:56 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190014, encodeId=10521900147e, content=可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8732047543, createdName=wen2009, createdTime=Mon Apr 24 00:11:46 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189759, encodeId=c129189e59a6, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=101c2041447, createdName=1881e9c2b1m, createdTime=Sun Apr 23 01:38:31 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189671, encodeId=310f1896e112, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Apr 22 16:30:53 CST 2017, time=2017-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189641, encodeId=4e1e18964115, content=非常好的研究,很受益。, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Apr 22 15:09:59 CST 2017, time=2017-04-22, status=1, ipAttribution=)]
    2017-04-24 wen2009

    可怕

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1789944, encodeId=43341e89944a7, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Wed Feb 28 23:36:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1646033, encodeId=54bd164603385, content=<a href='/topic/show?id=470051898b0' target=_blank style='color:#2F92EE;'>#心血管药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51898, encryptionId=470051898b0, topicName=心血管药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8b223291988, createdName=jiafufeng@yaho, createdTime=Mon Dec 11 06:36:00 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190961, encodeId=662719096101, content=学习了增加知识了分享了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Apr 27 06:24:57 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190333, encodeId=4f751903334d, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。点赞啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Apr 25 05:33:56 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190014, encodeId=10521900147e, content=可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8732047543, createdName=wen2009, createdTime=Mon Apr 24 00:11:46 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189759, encodeId=c129189e59a6, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=101c2041447, createdName=1881e9c2b1m, createdTime=Sun Apr 23 01:38:31 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189671, encodeId=310f1896e112, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Apr 22 16:30:53 CST 2017, time=2017-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189641, encodeId=4e1e18964115, content=非常好的研究,很受益。, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Apr 22 15:09:59 CST 2017, time=2017-04-22, status=1, ipAttribution=)]
    2017-04-23 1881e9c2b1m

    不错,学习了

    0

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    2017-04-22 1e10c84am36(暂无匿称)

    文章不错,值得分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1789944, encodeId=43341e89944a7, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Wed Feb 28 23:36:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1646033, encodeId=54bd164603385, content=<a href='/topic/show?id=470051898b0' target=_blank style='color:#2F92EE;'>#心血管药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51898, encryptionId=470051898b0, topicName=心血管药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8b223291988, createdName=jiafufeng@yaho, createdTime=Mon Dec 11 06:36:00 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190961, encodeId=662719096101, content=学习了增加知识了分享了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Apr 27 06:24:57 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190333, encodeId=4f751903334d, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。点赞啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Apr 25 05:33:56 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190014, encodeId=10521900147e, content=可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8732047543, createdName=wen2009, createdTime=Mon Apr 24 00:11:46 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189759, encodeId=c129189e59a6, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=101c2041447, createdName=1881e9c2b1m, createdTime=Sun Apr 23 01:38:31 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189671, encodeId=310f1896e112, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Apr 22 16:30:53 CST 2017, time=2017-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189641, encodeId=4e1e18964115, content=非常好的研究,很受益。, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Apr 22 15:09:59 CST 2017, time=2017-04-22, status=1, ipAttribution=)]
    2017-04-22 天涯183

    非常好的研究,很受益。

    0

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