Clin Gastroenterology H: 肥胖与克罗恩病风险增加有关但与溃疡性结肠炎无关

2021-07-14 MedSci原创 MedSci原创

从1980-2013年,超重成年人在发达国家已经增加了28%,发展中国家接近60%。在美国,超过三分之一的成年人肥胖。

      据估计,全球约有21亿成年人超重(BMI≥25kg/m2),其中6亿为肥胖(BMI≥30kg/m2),超重和肥胖的发病率已经达到了全球流行的程度。从1980-2013年,超重成年人在发达国家已经增加了28%,发展中国家接近60%。在美国,超过三分之一的成年人肥胖。

 

      在肥胖流行同时,炎症性肠病(IBD)患病率和发病率也呈全球上升趋势。一篇涉及260项以人群为基础研究的系统性综述估计,西方国家IBD每年发病率范围为10-30例/100000人;约5%成年人患IBD。尽管有令人信服的基础科学研究数据,但尚不清楚肥胖是否与炎症性肠病的发展有关。因此,本项研究旨在探究肥胖与克罗恩病 (CD) 和溃疡性结肠炎 (UC) 风险之间的关联。

 

 

      研究人员对5项相关的前瞻性队列进行了汇总分析,这些队列对体重指数 (BMI) 和腰臀比 (WHR) 以及其他生活方式因素进行了详细测量。CD 和 UC 的诊断通过医疗记录确认或使用经过验证的定义确定。然后使用 Cox 比例风险模型来计算合并的多变量调整 HR (aHR) 和 95% CI范围。

 

       在 601009 名参与者(年龄范围:18-98 岁)和 10110018 人年的随访时间中,研究人员确认了 563 例 CD 和 1047 例 UC的发生。与正常 BMI(18.5 至 <25kg/m2)相比,肥胖(基线 BMI ≥30kg/m2)与 CD 风险增加(aHR 1.34,95% CI 1.05-1.71,I2 =0% )相关。基线 BMI每增加5kg/m2与 CD 风险增加 16% 相关(aHR 1.16,95% CI 1.05-1.22,P=0.002)。同样,成年早期 BMI(18-20 岁)每增加5kg/m2,CD 风险增加 22%(aHR 1.22,95% CI 1.05-1.40,P=0.001)。WHR 的增加与 CD 风险的增加相关,但未达到统计学显着性,同时研究人员未观察到肥胖测量值与 UC 风险之间存在关联。

图:肥胖与炎症性肠病的关系

 

      本项研究证实在成年人群中,通过 BMI 衡量的肥胖与CD的发病风险增加有关,但与 UC 无关。

 

 

原始出处 :

Simon S.M. Chan. Et al. Obesity is associated with increased risk of Crohn’s disease, but not ulcerative colitis: A pooled analysis of five prospective cohort studies. Clin Gastroenterology H.2021.

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    2021-12-12 nymo
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    2021-11-28 许安
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    2021-07-31 aklovers

    减肥是必要的

    0

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    2021-07-15 言西早

    一胖百病生

    0

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