Eur Respir J:体重指数对非结核分枝杆菌性肺疾病发生率的影响

2020-08-14 MedSci原创 MedSci原创

BMI与NTM-PD的发生呈负相关,而体重减轻会增加NTM-PD的风险。

在世界范围内,非结核分枝杆菌性肺病(NTM-PD)的发病率和患病率一直在上升。营养不良人群NTM-PD的风险可能更高。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员试图阐明体重指数(BMI)及其变化对NTM-PD的影响。

研究人员进行了一项回顾性队列研究,纳入了年龄在40岁以上的韩国人,他们在2005年和2009年或2006年和2010年均接受了两年一次的国家健康保险系统(NHIS)健康检查。从研究开始日期(2009年或2010年NHIS健康检查日期)直到诊断为NTM-PD或2017年12月31日,研究人员对符合条件的个体进行了监测。根据入组时的BMI将受试者进行分类。研究人员通过计算风险比(HR),比较了根据BMI组别和BMI变化情况每100000人每年的NTM-PD发生率。

纳入最终分析的受试者共有5670229人。与BMI<18.5 kg·m-2组相比,NTM-PD的发生率随着BMI的增加而逐渐降低:BMI为18.5-22.9的受试者调整后HR(aHR)为0.38(95%置信区间[CI]为0.35-0.42),BMI为23-24.9的受试者为0.17(0.15-0.19),BMI为25-29.9的受试者为0.1(0.09-0.11),BMI≥30的受试者为0.01(0.07-0.13)。在4年中BMI降低≥1kg/m2会增加NTM-PD的发生率(aHR为1.08,95%CI为1.01-1.16),而BMI增加≥1会降低NTM-PD发生率(0.77,95%CI为0.71-0.83)。

总之,BMI与NTM-PD的发生呈负相关,而体重减轻会增加NTM-PD的风险。

原始出处:

Jin Hwa Song,et al.Impact of body mass index on development of nontuberculous mycobacterial pulmonary disease.Eur Respir J.2020.https://erj.ersjournals.com/content/early/2020/08/06/13993003.00454-2020

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