Arthritis Rheumatol:系统性红斑狼疮中的周围神经系统疾病

2019-08-26 xiangting MedSci原创

这项研究目的是在一个多民族/种族、前瞻性SLE初始队列中,确定不同类型周围神经系统(PNS)疾病的发病率、临床特征、相关性和结局。每年对患者进行19个神经精神(NP)事件评估,其中包括7种类型的PNS疾病。衡量SLE疾病活动性、器官损伤、自身抗体、患者和医师对结局的评估。适当时使用事件时间和线性回归。在1,827名SLE患者中,88.8%为女性,48.8%为高加索人。平均±SD年龄为35.1±13

这项研究目的是在一个多民族/种族、前瞻性SLE初始队列中,确定不同类型周围神经系统(PNS)疾病的发病率、临床特征、相关性和结局。

每年对患者进行19个神经精神(NP)事件评估,其中包括7种类型的PNS疾病。衡量SLE疾病活动性、器官损伤、自身抗体、患者和医师对结局的评估。适当时使用事件时间和线性回归。

在1,827名SLE患者中,88.8%为女性,48.8%为高加索人。平均±SD年龄为35.1±13.3岁,入组时的病程为5.6±4.2个月,随访时间为7.6±4.6年。139/1,827名患者(7.6%)中有161例PNS事件。主要事件是周围神经病变[66/161(41.0%)],单神经病变[44/161(27.3%)]和颅神经病变[39/161(24.2%)],并且大部分归因于SLE。多因素Cox回归分析表明,有神经病变既往史的患者达到缓解所需的时间更长,与其他神经病变相比,周围神经病患者SLE诊断时的年龄更大,SLEDAI-2K评分更高。与没有NP事件的患者相比,神经病变与SF-36躯体和心理成分总分明显降低相关。大多数神经病变随着时间推移消失或改善,这与周围神经病变和单神经病变的SF-36总评分的改善相关。

PNS疾病是NPSLE的重要组成部分,对健康相关生活质量有明显的负面影响。大多数患者的预后良好,但研究发现了与缓解时间较长相关的几个因素。

在线使用:
SF-36生活质量量表

原始出处:

John G. Hanly. Peripheral nervous system disease in Systemic Lupus Erythematosus: Results from an international, inception cohort study. Arthritis Rheumatol. 07 August 2019.

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    2019-08-28 zhaojie88
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与未受到虐待的女性相比,儿童期受到身体和情感虐待的女性患SLE风险明显升高。儿童期遭遇不幸有助于SLE的发展。

J Rheumatol:系统性红斑狼疮中的动脉粥样硬化血管事件

由于对经典冠脉危险因素和SLE的有效治疗,现代SLE的AVE发病率有明显下降。

J Rheumatol:系统性红斑狼疮的疲劳指标

VAS、FSS和FACIT-疲劳量表是2008年至2017年成人SLE研究中最常用的工具。