BMC Medicine:合理营养,减少COVID-19疫情下营养不良和肥胖

2021-04-22 MedSci原创 MedSci原创

大量证据表明,在食物短缺时期营养缺乏对健康有长期的影响。据估计,随着中低收入国家目前的大流行,COVID-19大流行将大幅增加各种形式的营养不良。特别令人关切但被低估的是,有可能增加营养不良和肥胖(营

大量证据表明,在食物短缺时期营养缺乏对健康有长期的影响。据估计,随着中低收入国家目前的大流行,COVID-19大流行将大幅增加各种形式的营养不良。特别令人关切但被低估的是,有可能增加营养不良和肥胖(营养不良双重负担DBM)。在中低收入国家,营养不良与超重和肥胖(或与饮食有关的非传染性疾病)并存的情况正在迅速增加。尽管多种因素导致DBM,但食物不安全(FI)和肠道微生物失调发挥了关键作用。营养不足和营养过剩都已证明是粮食不安全的后果。大流行已经造成食物供应的重大变化,对肠道微生物群产生了直接影响。肠道微生物群最近也被认为在营养不足和营养过剩中发挥作用,改变了二者的群落结构和功能。尽管中低收入国家在减少营养不良方面取得了很大进展,但这些国家仍然很脆弱。由于COVID-19的意外干扰,他们的许多成果将会丧失。在此,Paula Littlejohn & B. Brett Finlay描述了食品不安全和肠道微生物群与DBM的关系,以及在COVID-19大流行的背景下,这可能如何加剧。迫切需要采取行动减轻其中一些影响。

世界粮食计划署(粮食计划署)估计,到2020年,中低收入国家将有2.65亿人因大流行而遭受严重饥饿,几乎是原先预计的1.35亿人的两倍。粮食贸易的全球边境关闭、粮食生产的损失和家庭收入的明显下降将加剧饥饿,同时也将迫使家庭求助于高热量、缺乏营养的食品,从而加剧肥胖。食物不安全,即持续缺乏充足和营养丰富的食物,将主要驱动营养行为,肠道微生物群可能是一个关键的生物机制。大量的人类和动物研究将低多样性和炎症物种的增加描述为营养不良和营养过剩的肠道微生物群的特征。事实上,粪便移植研究表明,微生物群从营养不良和营养过剩的人类转移到缺乏微生物群的无菌小鼠,转移了物理和代谢表型,表明微生物群在营养不足和营养过剩中起因果作用。SARS-CoV-2与DBM结合后的微生物群失调呈现粘性循环。

低收入至中等收入国家可能会看到DBM流行病的增加。应该优先考虑提供有营养的食物和保护个人的肠道微生物群使“DBM轨迹曲线平坦”。

该文建议旨在使DBM曲线变平的中低收入国家应该优先考虑营养方面的努力。增加母乳喂养做法和获得低成本营养食品,这些已经证明的干预措施至关重要。此外,由于健康的肠道微生物群调节肠道之外的疾病,针对微生物群可能在对抗营养不良的斗争中有未实现的好处。益生菌和益生元调节肠道微生物群的作用已得到充分证实。利用这些见解可能会有效地减轻肠道微生物组的损害,而肠道微生物组会影响营养不良一个尚未探索的干预措施是加快社区使用微生物区系指导的补充食物(MDCF),这是一种由Gehrig等人设计的用于修复和加强微生物区系的饮食。MDCF被证明是一种恢复孟加拉国儿童代谢功能和微生物组结构的有效疗法。在当前的大流行中,将这些策略结合起来可能有助于改变DBM的发展轨迹。

原文出处

Littlejohn, P., & Finlay, B. B. (2021). When a pandemic and an epidemic collide: COVID-19, gut microbiota, and the double burden of malnutrition. BMC medicine19(1), 31. https://doi.org/10.1186/s12916-021-01910-z

 

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    2021-09-27 kalseyzl
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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/240d3ae7a8e8452d9f49793c3923ad60/78defa70ab2947c28066b378f1117648.jpg, createdBy=fa315475285, createdName=梅斯小助手, createdTime=Thu Apr 22 11:20:43 CST 2021, time=2021-04-22, status=1, ipAttribution=)]
    2021-05-14 ms6000001608459305

    0

  4. 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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/240d3ae7a8e8452d9f49793c3923ad60/78defa70ab2947c28066b378f1117648.jpg, createdBy=fa315475285, createdName=梅斯小助手, createdTime=Thu Apr 22 11:20:43 CST 2021, time=2021-04-22, status=1, ipAttribution=)]
    2021-05-06 莉莉安 Lillian C.

    宝贵的新鲜完整食物…

    0

  5. 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    2021-08-18 jeanqiuqiu
  6. 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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/240d3ae7a8e8452d9f49793c3923ad60/78defa70ab2947c28066b378f1117648.jpg, createdBy=fa315475285, createdName=梅斯小助手, createdTime=Thu Apr 22 11:20:43 CST 2021, time=2021-04-22, status=1, ipAttribution=)]
  7. 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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/240d3ae7a8e8452d9f49793c3923ad60/78defa70ab2947c28066b378f1117648.jpg, createdBy=fa315475285, createdName=梅斯小助手, createdTime=Thu Apr 22 11:20:43 CST 2021, time=2021-04-22, status=1, ipAttribution=)]
  8. 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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/240d3ae7a8e8452d9f49793c3923ad60/78defa70ab2947c28066b378f1117648.jpg, createdBy=fa315475285, createdName=梅斯小助手, createdTime=Thu Apr 22 11:20:43 CST 2021, time=2021-04-22, status=1, ipAttribution=)]
    2021-04-22 Lizhihua6

    学习了

    0

  9. 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    2021-04-22 SUPERCAI

    赞👍

    0

  10. 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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/240d3ae7a8e8452d9f49793c3923ad60/78defa70ab2947c28066b378f1117648.jpg, createdBy=fa315475285, createdName=梅斯小助手, createdTime=Thu Apr 22 11:20:43 CST 2021, time=2021-04-22, status=1, ipAttribution=)]
    2021-04-22 梅斯小助手

    三人行,必有我师。 #梅斯医学科研互助群# 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!

    0

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