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迄今最大规模研究表明：每天这样喝咖啡，或能延长寿命、降低心脏病风险！

2022-04-18 乐一 MedSci原创

咖啡心血管疾病PCSK9
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每天喝两到三杯咖啡，不仅可以降低心脏病和心率异常发病风险，还与寿命延长有关！而且，这一趋势对不论是否患有心血管疾病的人都适用。

咖啡，对于职场人士来说几乎是提神醒脑的必备饮品，有人把咖啡称为工作日的“续命水”，尤其到下午，困意袭来，不来杯咖啡都撑不到下班。
然而，并不是每个人都能理解“咖啡星人”的乐趣。“别喝那么多咖啡！对心脏不好！！！”诸如此类的“温馨提示”总会冷不丁的给人当头一棒。一直以来，喝咖啡都会被很多人认为是一件不健康的事情。因为咖啡中含有的咖啡因是一种中枢神经兴奋剂，可以刺激中枢神经系统，造成交感神经兴奋，进一步刺激心脏收缩，造成心跳加速、心慌等表现。因此人们每当出现这种状态时，都会很“顺理成章”地把这锅先甩给咖啡。
那么，事实真的是这样吗？
近日，第71届美国心脏病学会年度科学会议上，来自阿尔弗雷德大学教授兼心律失常研究负责人、医学博士Peter M. Kistler发表的最新研究为咖啡发声：每天喝两到三杯咖啡，不仅可以降低心脏病和心率异常发病风险，还与寿命延长有关！而且，这一趋势对不论是否患有心血管疾病的人都适用。

*小编谷歌得知：1 US cup= 236 mls

图片

（图片来源：ACC官网）

这是迄今最大规模的关于咖啡在心脏病和死亡风险中的潜在作用的研究分析。研究团队使用了来自英国生物银行的样本数据，包含50多万人的健康信息，这些人被追踪了至少10年。研究人员研究了这些参与者的咖啡摄入量（分为不喝咖啡、每天少于1杯、1杯、2-3杯、4-5杯、大于5杯）与心率问题、心血管疾病、死亡风险和心脏相关死亡风险之间的关联。
研究人员评估了382,535名没有已知心脏病的受试者的数据，以了解在10年的随访跟踪调查中，喝咖啡是否在心脏病或卒中的发展中发挥了作用。受试者的平均年龄为57岁，其中一半为女性。
有趣的是，研究人员发现，每天喝两到三杯咖啡的益处最大，可以降低10%-15%患冠心病、心力衰竭、心律失常或因任何原因死亡的风险。每天喝一杯咖啡的人中风或心脏相关死亡的风险最低。研究人员观察到咖啡摄入量与新的心律问题呈U型关系：每天喝两到三杯咖啡的人获益最大，而多喝或少喝咖啡的人获益较少。
图片
习惯性饮用咖啡对心血管疾病、心律失常和死亡率的影响。（图片来源：ACC官网）
此外，研究人员对常规咖啡摄入与心血管疾病死亡率改善间的相关性进行了探索，研究的对象是34,279名患有某种心血管疾病的成年人。与不喝咖啡的人相比，每天喝两到三杯咖啡的患者具有较低的死亡率。另外，在纳入分析的对象中有24,111名患有心律失常，喝咖啡使得他们有着更低的死亡风险。最重要的是，饮用任何量的咖啡都不会增加心律问题的风险，包括心房颤动或心房扑动。
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定期摄入咖啡与改善流行心血管疾病的死亡率有关。（图片来源：ACC官网）
甚至，为了全面替咖啡“平反”，研究者对咖啡种类不同产生的影响也进行了探究。
通过调查不同类型的咖啡——含咖啡因的咖啡、含咖啡因的速溶咖啡和不含咖啡因的咖啡与健康程度的关系，研究人员发现，无论喝的是现磨咖啡还是速溶咖啡，每天喝两到三杯，患心律失常、冠状动脉阻塞、卒中或心力衰竭的风险最低。饮用任何咖啡类型都可以降低死亡率。但是，不含咖啡因的咖啡对突发性心律失常并没有良好效果，虽然它确实能减少心血管疾病风险。
图片
不同咖啡类型摄入量与心律失常和心血管疾病的关系。（图片来源：ACC官网）
总而言之，这项大规模研究向人们传递了一个重要信息：定期摄入一定量的咖啡是安全并且有益的，甚至“对于心脏病患者来说，这可能是健康饮食的一部分。”主要作者Kistler博士表示。
看到这里，手里捧着某巴克、某幸咖啡的“咖星人”表示松了口气。那么，口味醇厚、提神醒脑的咖啡又为何会拥有如此神效呢？来自加拿大的研究人员在摄入咖啡因与心血管健康之间找到了分子机制上的解释。
这项研究发表在Nature Communications，研究人员揭示了摄入咖啡因会使血液中PCSK蛋白的水平降低，从而清除血液中的“坏”胆固醇，起到保护心血管系统的作用。
图片
（图片来源：Nature Communications）
众所周知，PCSK9是一种蛋白质，主要在肝脏表达并分泌到血液中，可降低肝脏处理过量低密度脂蛋白（LDL）胆固醇（即俗称的“坏”胆固醇）的能力。LDL胆固醇是心血管疾病风险的重要指标。当PCSK蛋白水平下降或活性受到抑制时，肝细胞表面的LDL受体会迅速去除血液中多余的LDL胆固醇。
当研究人员向体外培养的肝细胞中加入不同浓度的咖啡因，他们发现肝细胞分泌的PCSK9减少了，肝细胞表面LDL-R表达增多了，对胆固醇的摄取能力也更强了。并且加入的咖啡因浓度越高，效果越明显。
随后研究人员在人体实验中进行了验证：12名年龄在22-45岁之间的健康人空腹口服400mg的咖啡因（大约2杯咖啡的量），在服用后2小时、4小时，参与者血浆中的PCSK9水平分别降低了25%和21%。另一方面，小鼠实验证明，在腹腔注射咖啡因（50mg/kg）4小时后，小鼠血浆中PCSK9水平也降低，肝脏对胆固醇的摄取能力增强，血液里甘油三酯、胆固醇含量明显下降。
图片
小鼠血浆PCSK9、甘油三酯含量。（图片来源：Nature Communications）
 
图片
人类血浆PCSK9含量。（图片来源：Nature Communications）
随着这项研究的发表，咖啡甚至顺带在减肥人群中圈了一波粉。这大概就是为什么爱喝咖啡的人不仅瘦，心脏跳的也有劲儿的原因吧。
不过，尽管喝咖啡对人体有所裨益，但仍要“因人而异、适可而止”，当服用咖啡给人带来焦虑或者不舒服的感觉时，应当减少咖啡的摄入。同时，更加推荐大家饮用含咖啡因的咖啡，不加或少加奶精和糖会使得手里的咖啡更加健康~
 
参考文献

[1] Good News for Coffee Lovers: Daily Coffee May Benefitthe Heart. Retrieved Mar 24, 2022 fromhttps://www.acc.org/About-ACC/Press-Releases/2022/03/23/17/55/Good-News-for-Coffee-Lovers-Daily-Coffee-May-Benefit-the-Heart.

[2] Lebeau PF, Byun JH, Platko K, Saliba P, Sguazzin M, MacDonald ME, Paré G, Steinberg GR, Janssen LJ, Igdoura SA, Tarnopolsky MA, Wayne Chen SR, Seidah NG, Magolan J, Austin RC. Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance. Nat Commun. 2022 Feb 9;13(1):770. doi: 10.1038/s41467-022-28240-9.

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    2022-09-29 ylz8403

    #大规模#

    0

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    2022-06-15 ms9000001252711052

    学习了

    0

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    2022-04-19 hittouch

    #延长寿命#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2043485, encodeId=168c2043485b6, content=<a href='/topic/show?id=13304400293' target=_blank style='color:#2F92EE;'>#大规模#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44002, encryptionId=13304400293, topicName=大规模)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fce464, createdName=ylz8403, createdTime=Thu Sep 29 04:09:13 CST 2022, time=2022-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1226615, encodeId=94761226615ac, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6725528285, createdName=ms9000001252711052, createdTime=Wed Jun 15 16:35:01 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479903, encodeId=4a0414e99038c, content=<a href='/topic/show?id=456b4954350' target=_blank style='color:#2F92EE;'>#延长寿命#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49543, encryptionId=456b4954350, topicName=延长寿命)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9587588723, createdName=hittouch, createdTime=Tue Apr 19 12:09:13 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559750, encodeId=08d91559e5065, content=<a href='/topic/show?id=b8435162302' target=_blank style='color:#2F92EE;'>#心脏病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51623, encryptionId=b8435162302, topicName=心脏病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94f015012402, createdName=mgqwxj, createdTime=Tue Apr 19 12:09:13 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565759, encodeId=3f901565e59df, content=<a href='/topic/show?id=b8435162302' target=_blank style='color:#2F92EE;'>#心脏病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51623, encryptionId=b8435162302, topicName=心脏病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94f015012402, createdName=mgqwxj, createdTime=Tue Apr 19 12:09:13 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212178, encodeId=ea3b12121e8a5, content=学习了，, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=89f91314625, createdName=段志强, createdTime=Mon Apr 18 14:05:57 CST 2022, time=2022-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212063, encodeId=a7a9121206321, content=希望看到全文。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/9c448fe1b3b54fd7bc9477662f4861bb/4bdadad22bfd46f2921aabb4c40265d3.jpg, createdBy=a8d81938466, createdName=weigq, createdTime=Mon Apr 18 06:05:59 CST 2022, time=2022-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212088, encodeId=1f2a121208884, content=一杯的量又是多少？, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=bpzdtibmsicibqQ1PCpZdf5IA&s=100&t=1556293742, createdBy=1f845148248, createdName=1994wdw, createdTime=Mon Apr 18 08:29:25 CST 2022, time=2022-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212100, encodeId=a6cd12121006e, content=真是**了我的思维, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f91a5555640, createdName=ms5000000338064393, createdTime=Mon Apr 18 09:17:22 CST 2022, time=2022-04-18, status=1, ipAttribution=)]
    2022-04-19 mgqwxj

    #心脏病风险#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2043485, encodeId=168c2043485b6, content=<a href='/topic/show?id=13304400293' target=_blank style='color:#2F92EE;'>#大规模#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44002, encryptionId=13304400293, topicName=大规模)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fce464, createdName=ylz8403, createdTime=Thu Sep 29 04:09:13 CST 2022, time=2022-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1226615, encodeId=94761226615ac, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6725528285, createdName=ms9000001252711052, createdTime=Wed Jun 15 16:35:01 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479903, encodeId=4a0414e99038c, content=<a href='/topic/show?id=456b4954350' target=_blank style='color:#2F92EE;'>#延长寿命#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49543, encryptionId=456b4954350, topicName=延长寿命)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9587588723, createdName=hittouch, createdTime=Tue Apr 19 12:09:13 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559750, encodeId=08d91559e5065, content=<a href='/topic/show?id=b8435162302' target=_blank style='color:#2F92EE;'>#心脏病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51623, encryptionId=b8435162302, topicName=心脏病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94f015012402, createdName=mgqwxj, createdTime=Tue Apr 19 12:09:13 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565759, encodeId=3f901565e59df, content=<a href='/topic/show?id=b8435162302' target=_blank style='color:#2F92EE;'>#心脏病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51623, encryptionId=b8435162302, topicName=心脏病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94f015012402, createdName=mgqwxj, createdTime=Tue Apr 19 12:09:13 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212178, encodeId=ea3b12121e8a5, content=学习了，, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=89f91314625, createdName=段志强, createdTime=Mon Apr 18 14:05:57 CST 2022, time=2022-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212063, encodeId=a7a9121206321, content=希望看到全文。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/9c448fe1b3b54fd7bc9477662f4861bb/4bdadad22bfd46f2921aabb4c40265d3.jpg, createdBy=a8d81938466, createdName=weigq, createdTime=Mon Apr 18 06:05:59 CST 2022, time=2022-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212088, encodeId=1f2a121208884, content=一杯的量又是多少？, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=bpzdtibmsicibqQ1PCpZdf5IA&s=100&t=1556293742, createdBy=1f845148248, createdName=1994wdw, createdTime=Mon Apr 18 08:29:25 CST 2022, time=2022-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212100, encodeId=a6cd12121006e, content=真是**了我的思维, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f91a5555640, createdName=ms5000000338064393, createdTime=Mon Apr 18 09:17:22 CST 2022, time=2022-04-18, status=1, ipAttribution=)]
    2022-04-19 mgqwxj

    #心脏病风险#

    0

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    2022-04-18 段志强

    学习了，

    0

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    2022-04-18 weigq

    希望看到全文。

    0

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    2022-04-18 1994wdw

    一杯的量又是多少？

    0

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    2022-04-18 ms5000000338064393

    真是**了我的思维

    0

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