Int J Rheum Dis:长期随访结果表明手术仍然是强直性脊柱炎患者AL的更佳治疗方法

2021-05-04 MedSci原创 MedSci原创

强直性脊柱炎(AS)是一种众所周知的慢性炎症性风湿病,会导致脊柱结构的渐进性损伤和运动受限。Andersson病变(AL)是AS患者的罕见并发症,表现为脊柱的破坏性椎体或发现性椎体病变。大多数关于AL

强直性脊柱炎(AS)是一种众所周知的慢性炎症性风湿病,会导致脊柱结构的渐进性损伤和运动受限。Andersson病变(AL)是AS患者的罕见并发症,表现为脊柱的破坏性椎体或发现性椎体病变。大多数关于AL的临床研究都是基于病例报告和小样本的回顾性研究,所以缺乏对这种病变的中长期结果的大规模调查。近日,研究人员利用中长期随访数据评估了AL治疗的临床疗效和预后因素,并探讨了AL的临床特点和治疗方法,研究结果已发表于Int J Rheum Dis。

2011年6月至2018年3月,研究人员对48例连续AL病例进行了回顾性分析,包括13例保守治疗和35例手术治疗。回顾了流行病学特征、治疗方式、临床特征和结果,以及日本骨科协会(JOA)康复率的预后因素。通过美国脊柱损伤协会(ASIA)的分类进行评估患者神经功能的恢复。由JOA评分、视觉模拟量表(VAS)评分和Cobb角度来评价临床疗效。

 

结果,平均总体随访时间为(44.5±18.5)个月(范围为27-85个月)。36名男性和12名女性患者,平均年龄为49.4±13.1岁(范围,26-72岁)。最常见的病变位置是胸腰部,即T10-L2(n=33;68.8%),其次是胸椎(n=10)和腰椎(n=5)。在最后的随访中,手术治疗的患者的JOA评分、VAS评分和Cobb's角度都明显优于保守治疗的患者(P<.05)。单变量和二元逻辑回归分析确定了影响JOA评分恢复率的两个预后因素:治疗方式(OR=0.157;95%CI,0.028-0.89;P=0.036)和骨融合(OR=9.965;95%CI,2.052-48.387;P=0.004)。保守治疗和骨不连预示着更差的JOA评分恢复。

综上所述,该研究结果表明,手术仍然是强直性脊柱炎患者AL的最佳治疗方法,中长期随访数据证明了其更好的临床疗效。

 

原始出处:

 

Minhao Wu, et al., Effects of Andersson lesion treatment in ankylosing spondylitis: A medical record review study focused on medium- to long-term outcomes. Int J Rheum Dis. 2020 Jun;23(6):753-762. doi: 10.1111/1756-185X.13826.  

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    2021-08-11 zywlvao
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    2021-05-12 ms5000000790714074

    受益匪浅#学习#

    0

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