Arthritis Rheumatol:银屑病关节炎的高冠脉斑块负荷与代谢综合征无关,并与潜在疾病严重性相关

2017-12-07 xiangting MedSci原创

PsA与加快的冠脉斑块形成有关,特别是混合斑块,与代谢疾病无关。

这篇文章旨在探讨代谢综合征(Metsy)和银屑病相关变量对银屑病关节炎(PsA)患者冠脉斑块负荷的影响。

无冠脉疾病(CAD)症状的50例PsA患者(25例患Metsy,25例无Metsy(NMetsy))和50例年龄和性别匹配的对照接受64排冠脉CT血管造影(CCTA)。计算斑块定位,节段累及评分(SIS),狭窄严重度评分(SSS)和总斑块体积(TPV)。斑块分为钙化(CP),混合(MP)和非钙化斑块(NCP)。采用Kruskal-Wallis检验,秩相关和线性回归分析研究PsA、Metsy与斑块负荷的关系。

76%PsA vs.44%对照有斑块(P = 0.001),PsA患者冠脉受累的比例较高(P = 0.007)。与对照组相比,PsA的SIS、SSS和TPV更高(分别为P = 0.003,P = 0.001,P = <0.001)。与对照组相比,更多的PsA患者有MPs,MP体积更高(P = <0.001)。Metsy的 PsA患者与NMetsy患者具有相似的斑块负荷和类型。SIS、SSS和TPV与Metsy的特征没有显著关系,但是与疾病活动度有显著相关性。TPV与PsA的诊断相关(B = 0.865,P = 0.008),但与Metsy无关。年龄,CRP max,SJC max,病程和血糖是PsA斑块负荷较高的独立预测因子。

PsA与加快的冠脉斑块形成有关,特别是混合斑块,与代谢疾病无关。银屑病疾病活动性和严重程度可能比传统风险因素能够更好地预测冠脉斑块负荷。

原始出处:

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    2018-06-08 xue8602
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    2017-12-09 lmm397
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    2017-12-09 zhaojie88
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