ATVB:IL-6是传统危险因素与心肌梗死之间关联的介导因素

2021-03-06 MedSci原创 MedSci原创

血浆IL-6和IL-6二元复合物浓度与未来心肌梗死显著相关。该研究的数据表明血浆IL-6和IL-6二元复合物的浓度升高均可以部分解释这一关联,其可能与吸烟者和高血压参与者MI发生风险增加有关。

目前,缺乏阐明白介素-6(IL-6)信号转导与未来心肌梗塞(MI)风险之间相关性的研究。此外,尚未有研究探讨升高的IL-6是否解释了传统危险因素与未来MI之间的部分关联。

近日,血管领域权威杂志Arteriosclerosis, Thrombosis, and Vascular Biology上发表了一篇研究文章,研究人员进行了一项嵌套病例对照研究,纳入了584名参与者(292例病例和292例对照者)。在基线时,研究人员测量了受试者血浆胆固醇水平,并收集了参与者的临床特征。

在这项研究中,研究人员测量了IL-6、sIL-6R(可溶性IL-6受体)和sgp130(可溶性gp130)的血浆浓度。为了估计IL-6信号转导的程度,研究人员评估了一种新型生物标记物-IL-6二元复合物的血浆浓度。

与没有经历MI的参与者相比,MI患者的IL-6二元复合物浓度显著升高。单因素分析表明,IL-6二元复合物升高2倍与未来MI发生风险增加2.45倍相关(相对风险95%CI为1.65-3.66,P<0.001)。受试者工作特征分析发现,IL-6二元复合物(曲线下面积为0.614)的预测性能与IL-6(曲线下面积为0.603)相同。此外,使用过程调解分析工具,研究人员发现吸烟和高血压对未来MI具有统计学显著的间接效应,并且是通过增加血浆IL-6二元复合物或IL-6所介导。

由此可见,血浆IL-6和IL-6二元复合物浓度与未来心肌梗死显著相关。该研究的数据表明血浆IL-6和IL-6二元复合物的浓度升高均可以部分解释这一关联,其可能与吸烟者和高血压参与者MI发生风险增加有关。

原始出处:

Mulugeta M. Zegeye.et al.IL-6 as a Mediator of the Association Between Traditional Risk Factors and Future Myocardial Infarction A Nested Case-Control Study.ATVB.2021.https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.315644

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    2021-04-28 gongliu
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    2021-03-08 kzlchina
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    2021-03-06 minzhusu

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