类风湿性关节炎的发病全过程

2017-06-08 佚名 风湿百科

案例分型张女士,38岁,平时做些家务、织织毛衣。但从去年开始一直被关节疼痛困扰。起初,只是晨起双手指关节有绷紧感,活动不灵活,但活动一阵子后就减轻缓解了。一段时间后,从手指逐渐发展至双腕、双膝、双踀趾关节也出现僵硬不灵活现象,严重时关节肿胀、疼痛。这些症状往往在阴雨天气加重,伴有胃口不好,发低烧。张女士以为是自己多吹了空调,只要注意保暖多休息就行了。半年过去了,关节僵硬、肿胀、疼痛竟比过去更严重了

案例分型

张女士,38岁,平时做些家务、织织毛衣。但从去年开始一直被关节疼痛困扰。

起初,只是晨起双手指关节有绷紧感,活动不灵活,但活动一阵子后就减轻缓解了。

一段时间后,从手指逐渐发展至双腕、双膝、双踀趾关节也出现僵硬不灵活现象,严重时关节肿胀、疼痛。这些症状往往在阴雨天气加重,伴有胃口不好,发低烧。张女士以为是自己多吹了空调,只要注意保暖多休息就行了。

半年过去了,关节僵硬、肿胀、疼痛竟比过去更严重了,有时不能正常活动。去了医院,经风湿免疫科医生诊断,才得知是患了类风湿关节炎。

检查确诊

经检查,张女士双手、腕、双膝、双踀趾关节肿胀、疼痛、圧痛明显、活动障碍;血沉及类风因子明显增高;X线显示:双手、腕关节间隙狭窄,关节周围软组织肿胀,抗CCP抗体阳性。

不少关节痛的病人对类风湿缺乏了解,关节疼痛以为仅仅只是受了风寒。其实,类风湿关节炎是一种关节病变为主的慢性自身免疫性疾病,通常会导致关节疼痛、僵硬、肿胀、活动受限,这些症状往往与天气变化有关。

除了关节滑膜、软骨受到损害,关节周围的韧带、肌腱和相连的骨骼都会有病变。病变还可累及心、肺、血管等多个器官和组织。

因此,类风湿关节炎是一个除关节病变外,同时可伴有机体多系统损害的自身免疫性疾病。

类风湿如何起病

类风湿可见于任何年龄,发病随着年龄增长而增加。以女性多发,是男性患者的2-3倍。

类风湿大多起病隐匿,像上述张女士那样,时轻时重,反复发作,逐渐加重,往往不引起重视,以此种方式病者约占60~70%,病人往往也难以说明发病的具体日期。病程也长短不一。

最初期除有局部关节症状外,亦可伴有全身不适,部分病人先有疲乏无力,低热,食欲减退,体重下降、骨骼肌疼痛及手足麻木刺痛等症状。

像张女士那样,早晨醒来时手指关节不灵活,活动后减轻,这种现象叫“晨僵”,晨僵是类风湿关节炎的首发症状。

随着疾病的发展,会出现关节疼痛、肿胀、呈对称性。关节周围皮肤温热、潮红,当自动或被动运动时都会引起疼痛。

先多见于手指、足趾,近侧指间关节呈梭状肿大,最为常见。

继之可见于掌跖、腕、肘、肩、踝、膝、髋等关节。呈窜痛、冷痛、胀痛、酸痛,得温则舒。遇寒痛增,关节附近肌肉僵硬和萎缩。受累关节变成僵硬而畸形,膝、肘、手指、腕部都固定在屈位,最后不能动弹。

少数呈急性发病,突然一个关节或多个关节红种,呈漫肿,灼痛,其痛彻骨,压痛明显,甚至痛不可触,关节活动受限,或完全不能活动。血清粘蛋白增高,关节X线可见,关节肿胀,关节间隙增宽及关节周围软组织肿胀。

类风湿起病方式

类风湿关节炎有不同的起病方式。按起病的急缓分为隐匿型(约占50%)、亚急型(约占35%-40%)、突发型(约占10%-25%)三类。

按发病部位分为:多关节型,少关节型、单关节型及关节外型,后者可以以腱鞘炎、滑囊炎、多发性肌痛起病,亦可表现为系统性血管炎、肺纤维化或乏力、消瘦等周身症状。

临床上类风湿起病方式分类

如果将发病时间与发病部位两者结合起来,通常将RA的起病分为如下几类:

(1)逐渐起病:病人只能说出发病大致的月份。大多为对称性的多个外周小关节受累,如腕关节、掌指关节、近端指间关节、踝关节和趾关节。晨僵比较显着。

(2)隐匿性单关节起病:常首先累及大关节,在一段时间内病变局限于该关节,但最终可扩散到腕、指、踝、趾等多个关节。

(3)突发性多关节受累:少数患者可以突然出现肩、肘、腕、指、髓、膝、踝等多关节明显疼痛,弥漫性肿胀,关节活动受限。病人可以准确说出发病的日期。这种发作方式可见于任何年龄的病人,但以老年为主。随着病程的进展而出现典型的RA临床表现。这种起病方式需与缓解性血清阴性对称性滑膜炎伴可凹性水肿进行鉴别。

(4)急性单关节受累:以膝、肘、肩关节受累为主,感染、假性痛风、痛风等有类似表现,但疼痛较重,滑液化验有助于鉴别。

(5)滑囊炎和腱鞘炎可以是 RA的首发表现。有些患者以腕管综合征的症状就诊。

(6)老年患者中有以多发肌痛、多关节痛的症状起病,累及颈部、肩、肘、膝关节,乏力明显,发热可持续数月,加之血沉增快,类似风湿性多肌痛。最终进展为典型的RA。

一般说来,只要早发现并在早期进行积极的综合性治疗,预后较好,易于恢复。如治疗不及时,延误时机,晚期可致残废,预后较差。

因此,如果出现以上任何一条类风湿关节炎症状,请及时的去有风湿科的医院进行详细检查,作出正确的诊断,以便及早诊治。

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    2017-06-10 lmm397
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level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jun 09 08:22:09 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208500, encodeId=dd7320850072, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Jun 09 08:09:15 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208474, encodeId=1ebc2084e481, content=这个很不错,学习提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Jun 09 07:31:36 CST 2017, time=2017-06-09, status=1, ipAttribution=)]
    2017-06-10 wei834766788

    很好!学习了!!!!

    0

  6. 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level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jun 09 08:22:09 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208500, encodeId=dd7320850072, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Jun 09 08:09:15 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208474, encodeId=1ebc2084e481, content=这个很不错,学习提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Jun 09 07:31:36 CST 2017, time=2017-06-09, status=1, ipAttribution=)]
    2017-06-09 133****4869

    诊断特点要掌握。

    0

  7. 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level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jun 09 08:22:09 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208500, encodeId=dd7320850072, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Jun 09 08:09:15 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208474, encodeId=1ebc2084e481, content=这个很不错,学习提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Jun 09 07:31:36 CST 2017, time=2017-06-09, status=1, ipAttribution=)]
    2017-06-09 Y—xianghai

    学习了,唉!我妈妈就是得了此病。

    0

  8. 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level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jun 09 08:22:09 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208500, encodeId=dd7320850072, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Jun 09 08:09:15 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208474, encodeId=1ebc2084e481, content=这个很不错,学习提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Jun 09 07:31:36 CST 2017, time=2017-06-09, status=1, ipAttribution=)]
    2017-06-09 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0

  9. 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level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jun 09 08:22:09 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208500, encodeId=dd7320850072, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Jun 09 08:09:15 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208474, encodeId=1ebc2084e481, content=这个很不错,学习提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Jun 09 07:31:36 CST 2017, time=2017-06-09, status=1, ipAttribution=)]
    2017-06-09 明月清辉

    谢谢分享,学习了

    0

  10. 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level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jun 09 08:22:09 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208500, encodeId=dd7320850072, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Jun 09 08:09:15 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208474, encodeId=1ebc2084e481, content=这个很不错,学习提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Jun 09 07:31:36 CST 2017, time=2017-06-09, status=1, ipAttribution=)]
    2017-06-09 飛歌

    这个很不错,学习提高了

    0

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