BMJ:遗传风险、健康生活方式和卒中

2018-10-25 xing.T MedSci原创

在该队列研究中,遗传和生活方式因素与卒中事件独立相关。这些结果强调了坚持健康生活方式对整个人群的益处,并且独立于遗传风险。

近日,顶级杂志BMJ上发表了一篇研究文章,研究人员旨在评估多基因风险评分和健康生活方式与卒中的相关性。

该研究为基于人群的前瞻性队列研究,以英国生物银行为基础。参与者为在2006年至2010年间招募的306473名男性和女性,年龄为40-73岁。研究人员采用Cox回归估计了首次卒中的风险比。在P<1×10-5时构建了先前与卒中相关的90个单核苷酸多态性的多基因风险评分,以评估与卒中的关联。坚持健康的生活方式取决于四个因素:非吸烟者、健康饮食、体重指数<30kg/m2以及定期体育锻炼。

在中位随访7.1年(2138443人次每年)期间,研究人员确定了2077例卒中(1541例缺血性卒中,287例脑内出血和249例蛛网膜下腔出血)患者。高遗传风险(多基因评分的前三分之一)与低遗传风险(后三分之一)相比,卒中风险高出35%:风险比为1.35(95%置信区间为1.21-1.50),P=3.9 ×10-8。与健康的生活方式(3或4个健康生活方式因素)相比,不良的生活方式(0或1个健康生活方式因素)与卒中风险增加66%相关:1.66(1.45-1.89),P=1.19×10-13。卒中与生活方式的关联独立于遗传风险分层。

在该队列研究中,遗传和生活方式因素与卒中事件独立相关。这些结果强调了坚持健康生活方式对整个人群的益处,并且独立于遗传风险。 

原始出处:

Loes CA Rutten, et al.Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants.BMJ 2018; https://www.bmj.com/content/363/bmj.k4168

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    2019-06-01 gaoxiaoe
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    2018-10-28 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  4. 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  5. 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  6. 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    2018-10-27 清风拂面

    谢谢分享学习

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Oct 27 07:27:03 CST 2018, time=2018-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350556, encodeId=949835055633, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri Oct 26 08:40:06 CST 2018, time=2018-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350555, encodeId=b17635055554, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Fri Oct 26 08:23:57 CST 2018, time=2018-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350546, encodeId=72353505460c, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Fri Oct 26 07:10:05 CST 2018, time=2018-10-26, status=1, ipAttribution=), 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    2018-10-26 龙胆草

    学习谢谢分享

    0

  8. 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    2018-10-26 183****7028

    学习

    0

  9. 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    2018-10-26 深海的鱼

    学习学习学习

    0

  10. 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    2018-10-26 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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