Hypertension:1期高血压的准妈妈服用阿司匹林可否降低先兆子痫风险?

2018-07-09 徐钰琦 环球医学

2018年7月,发表于《Hypertension》上的一项研究,考察了高风险队列中,阿司匹林对与1期高血压相关的不良妊娠结局的影响。

2018年7月,发表于《Hypertension》上的一项研究,考察了高风险队列中,阿司匹林对与1期高血压相关的不良妊娠结局的影响。

最近,美国心脏病学会/美国心脏协会(ACC/AHA)的临床实践指南工作组更新了慢性高血压诊断的建议。新分级系统包括血压为130~139/80~89mmHg的成人1期高血压的诊断。研究者旨在比较1期高血压合并高风险先兆子痫孕妇的结局,评估与高风险血压正常的孕妇相比,1期高血压孕妇是否会从阿司匹林治疗中获益。

研究者进行了一项高风险阿司匹林试验的二次分析,纳入了既往先兆子痫或糖尿病的孕妇。这些孕妇中,827人(81%)为血压正常,而193人(19%)为1期高血压。安慰剂治疗的孕妇中,调整了产妇年龄和体脂指数后,1期高血压孕妇比血压正常的高风险孕妇发生先兆子痫风险显著升高(39.1% vs 15.1%;风险比,2.49;95%CI,1.74~3.55)。进一步分析,1期高血压孕妇使用阿司匹林预防显著降低相关风险(风险比,0.61;95%CI,0.39~0.94),而血压正常的高风险孕妇并非如此(风险比,0.97;95%CI 0.70~1.34])。ACC/AHA指南在高风险人群中的实践证实,在控制其他风险因素的情况下,与血压正常的高血压孕妇相比,1期高血压与先兆子痫风险的显著性增加相关。

这些结果强调了意识到1期高血压为高风险先兆子痫孕妇的额外风险因素以及阿司匹林用于先兆子痫可获益的重要性。

原始出处:

Hauspurg A, Sutton EF, Catov JM, et.al. Aspirin Effect on Adverse Pregnancy Outcomes Associated With Stage 1 Hypertension in a High-Risk Cohort. Hypertension. 2018 Jul;72(1):202-207. doi: 10.1161/HYPERTENSIONAHA.118.11196. Epub 2018 May 25.

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