Gastroenterology:米索前列醇可治疗因阿司匹林导致的小肠出血

2018-07-03 zhangfan MedSci原创

研究认为,对于因阿司匹林持续治疗导致小肠出血的患者,米索前列醇可在不停药的情况下促进小肠溃疡面愈合

目前尚无有效的因阿司匹林导致小肠溃疡出血的药物治疗方法。近日研究人员考察了米索前列醇对持续性阿司匹林小肠出血患者的愈合效果。

研究招募了84名因服用阿司匹林导致小肠出血的患者,患者经胶囊内镜检查存在小肠溃疡或多重糜烂,随机接受米索前列醇(200 ug, 每天4次; n=42)或安慰剂(n=42) ,持续8周,所有患者每天仍服用100mg的阿司匹林。研究的主要终点为内镜溃疡完全愈合,次要终点为血红蛋白水平和溃疡/糜烂数量变化。

米索前列醇组12名患者实现溃疡完全愈合,而安慰剂组仅4人实现完全愈合(28.6% vs 9.5%)。与安慰剂相比,米索前列醇治疗平均血红蛋白增加(平均差异0.70 mg/dL)以及溃疡/糜烂数量减少(平均减少4.5处vs 3处)更为显著。

研究认为,对于因阿司匹林持续治疗导致小肠出血的患者,米索前列醇可在不停药的情况下促进小肠溃疡面愈合。

原始出处:

Moe H. Kyaw et al. Misoprostol Heals Small Bowel Ulcers in Aspirin Users With Small Bowel Bleeding. Gastroenterology. July 2, 2018.

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    2019-03-05 许安
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objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue Jul 03 07:37:37 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2018-07-03 通通

    临床治疗提供了新参考.

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jul 03 09:58:39 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328917, encodeId=1c3232891e77, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Jul 03 08:08:49 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328910, encodeId=5df3328910ba, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue Jul 03 07:37:37 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2018-07-03 神功盖世

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue Jul 03 07:37:37 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2018-07-03 龙胆草

    学习谢谢分享

    0

  10. 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    2018-07-03 kafei

    了解一下谢谢

    0

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