NEJM:恢复期血浆治疗新冠肺炎,一波三折再现曙光!

2021-01-14 MedSci原创 MedSci原创

对于未接受机械通气的新冠肺炎住院患者,接受高滴度抗体血浆治疗有助于患者康复

恢复期血浆用于治疗呼吸系统感染的历史已有100多年,1918年流感大流行期间,恢复期患者血浆或血清已被广泛的使用。新冠肺炎患者恢复期血浆是临床治疗的常用手段,但其疗效差异很大,可能因素在于抗体水平的差异显著。
 
在中国国内,对于新冠肺炎,较早采用恢复期血浆治疗,但是没有严格的随机对照试验,详细见:JAMA:恢复期血浆治疗COVID-19的可能性与挑战,同时,国内还专门发布了共识:新冠肺炎康复者恢复期血浆临床治疗方案(试行第二版)
 
但是,恢复期血浆用于新冠肺炎可谓一波三折。在先前的研究中观察到在恢复期血浆治疗的患者和接受安慰剂的患者之间,临床状态或总体死亡率方面未观察到显著差异,详细见:NEJM:新冠患者的恢复期血浆——被高估的抗体治疗。这项研究也得到另外一项研究结果的应证,文章发表在BMJ上,详细见:BMJ:恢复期血浆用于中度新冠肺炎住院患者的治疗效果评估
 
这项研究则是进一步观察了恢复期血浆的抗体水平与患者死亡风险的关系。
 
本次研究为对美国国家登记数据的回顾性研究,研究人员测定了用于治疗Covid-19住院患者的恢复期血浆中抗SARS-Cov-2 IgG抗体水平,使用Vitros抗SARS-Cov-2IgG化学发光免疫分析法评估血清结合抗体水平,定义信噪比低于4.62的血浆抗体水平为低,4.62-18.45为中等,高于18.45为高。研究的主要终点为血浆治疗后30天患者死亡。
 
3082名患者参与研究,515名患者接受高滴度抗体血浆治疗,2006名患者接受中等滴度抗体血浆治疗,而561名患者接受低滴度抗体血浆治疗,各组30天死亡患者人数分别为115例、549例和166例(22.3% vs27.4% vs 29.6%)。调整机械通气后,治疗血浆的抗体水平与患者死亡风险中等相关,对于未接受机械通气的患者,高滴度抗体血浆治疗组患者的30天死亡风险低于低滴度抗体治疗组(RR=0.66),但对于接受机械通气患者,高滴度抗体血浆治疗的效果不显著(RR=1.02)
 
研究认为,对于未接受机械通气的新冠肺炎住院患者,接受高滴度抗体血浆治疗有助于患者康复
 
梅斯医学认为,对于科学问题的探索是无止境的,不能因为一时的成败而放弃或肯定,从恢复期血浆的案例中可以看出,既不能神话这种方法,也不能因为部分研究是阴性结果而抛弃它,要理性和辩证地看待临床问题,并进行深入地探索。
 
原始出处:
 
Michael J. Joyner et al. Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19. N Engl J Med, January 13, 2021.

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    2021-04-09 by2009
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    2021-07-19 yangpeizhi
  4. [GetPortalCommentsPageByObjectIdResponse(id=1953048, encodeId=d90a1953048cc, content=<a href='/topic/show?id=bafc5283ed3' target=_blank style='color:#2F92EE;'>#恢复期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52837, encryptionId=bafc5283ed3, topicName=恢复期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Fri Apr 09 02:29:39 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667234, encodeId=62c1166e2343e, content=<a href='/topic/show?id=ea04891988c' target=_blank style='color:#2F92EE;'>#血浆治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89198, encryptionId=ea04891988c, topicName=血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150026134820, createdName=jianjun75, createdTime=Sun Jan 31 13:29:39 CST 2021, time=2021-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725196, encodeId=b3d81e2519629, content=<a href='/topic/show?id=58476021257' target=_blank style='color:#2F92EE;'>#曙光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60212, encryptionId=58476021257, topicName=曙光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=180c33737541, createdName=yangpeizhi, createdTime=Mon Jul 19 03:29:39 CST 2021, time=2021-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587298, encodeId=0586158e298ef, content=<a href='/topic/show?id=a6785283909' target=_blank style='color:#2F92EE;'>#恢复期血浆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52839, encryptionId=a6785283909, topicName=恢复期血浆)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f73917462216, createdName=doctorzheng, createdTime=Sat Jan 16 01:29:39 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916645, encodeId=aae5916645e4, content=<a href='/topic/show?id=d5161040529e' target=_blank style='color:#2F92EE;'>#恢复期血浆治疗#</a>又有用了!看来有没有作用,主要看血浆中的抗体多与少!, beContent=null, objectType=article, channel=null, level=null, likeNumber=206, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104052, encryptionId=d5161040529e, topicName=恢复期血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily, createdTime=Thu Jan 14 21:47:13 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916581, encodeId=da1d9165818d, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Thu Jan 14 17:21:22 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916508, encodeId=01aa916508da, content=感谢梅斯医学分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201221/137a6965d29349108c0e34d1034c142d/7d4214f027494937a9ccbccf0d523684.jpg, createdBy=84b02217108, createdName=孤舟蓑笠一老翁, createdTime=Thu Jan 14 14:08:42 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028999, encodeId=14bc1028999e1, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Thu Jan 14 13:29:39 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035551, encodeId=be5f103555199, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jan 14 13:29:39 CST 2021, time=2021-01-14, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1953048, encodeId=d90a1953048cc, content=<a href='/topic/show?id=bafc5283ed3' target=_blank style='color:#2F92EE;'>#恢复期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52837, encryptionId=bafc5283ed3, topicName=恢复期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Fri Apr 09 02:29:39 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667234, encodeId=62c1166e2343e, content=<a href='/topic/show?id=ea04891988c' target=_blank style='color:#2F92EE;'>#血浆治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89198, encryptionId=ea04891988c, topicName=血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150026134820, createdName=jianjun75, createdTime=Sun Jan 31 13:29:39 CST 2021, time=2021-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725196, encodeId=b3d81e2519629, content=<a href='/topic/show?id=58476021257' target=_blank style='color:#2F92EE;'>#曙光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60212, encryptionId=58476021257, topicName=曙光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=180c33737541, createdName=yangpeizhi, createdTime=Mon Jul 19 03:29:39 CST 2021, time=2021-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587298, encodeId=0586158e298ef, content=<a href='/topic/show?id=a6785283909' target=_blank style='color:#2F92EE;'>#恢复期血浆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52839, encryptionId=a6785283909, topicName=恢复期血浆)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f73917462216, createdName=doctorzheng, createdTime=Sat Jan 16 01:29:39 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916645, encodeId=aae5916645e4, content=<a href='/topic/show?id=d5161040529e' target=_blank style='color:#2F92EE;'>#恢复期血浆治疗#</a>又有用了!看来有没有作用,主要看血浆中的抗体多与少!, beContent=null, objectType=article, channel=null, level=null, likeNumber=206, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104052, encryptionId=d5161040529e, topicName=恢复期血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily, createdTime=Thu Jan 14 21:47:13 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916581, encodeId=da1d9165818d, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Thu Jan 14 17:21:22 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916508, encodeId=01aa916508da, content=感谢梅斯医学分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201221/137a6965d29349108c0e34d1034c142d/7d4214f027494937a9ccbccf0d523684.jpg, createdBy=84b02217108, createdName=孤舟蓑笠一老翁, createdTime=Thu Jan 14 14:08:42 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028999, encodeId=14bc1028999e1, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Thu Jan 14 13:29:39 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035551, encodeId=be5f103555199, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jan 14 13:29:39 CST 2021, time=2021-01-14, status=1, ipAttribution=)]
    2021-01-14 lifefamily

    #恢复期血浆治疗#又有用了!看来有没有作用,主要看血浆中的抗体多与少!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1953048, encodeId=d90a1953048cc, content=<a href='/topic/show?id=bafc5283ed3' target=_blank style='color:#2F92EE;'>#恢复期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52837, encryptionId=bafc5283ed3, topicName=恢复期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Fri Apr 09 02:29:39 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667234, encodeId=62c1166e2343e, content=<a href='/topic/show?id=ea04891988c' target=_blank style='color:#2F92EE;'>#血浆治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89198, encryptionId=ea04891988c, topicName=血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150026134820, createdName=jianjun75, createdTime=Sun Jan 31 13:29:39 CST 2021, time=2021-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725196, encodeId=b3d81e2519629, content=<a href='/topic/show?id=58476021257' target=_blank style='color:#2F92EE;'>#曙光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60212, encryptionId=58476021257, topicName=曙光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=180c33737541, createdName=yangpeizhi, createdTime=Mon Jul 19 03:29:39 CST 2021, time=2021-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587298, encodeId=0586158e298ef, content=<a href='/topic/show?id=a6785283909' target=_blank style='color:#2F92EE;'>#恢复期血浆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52839, encryptionId=a6785283909, topicName=恢复期血浆)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f73917462216, createdName=doctorzheng, createdTime=Sat Jan 16 01:29:39 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916645, encodeId=aae5916645e4, content=<a href='/topic/show?id=d5161040529e' target=_blank style='color:#2F92EE;'>#恢复期血浆治疗#</a>又有用了!看来有没有作用,主要看血浆中的抗体多与少!, beContent=null, objectType=article, channel=null, level=null, likeNumber=206, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104052, encryptionId=d5161040529e, topicName=恢复期血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily, createdTime=Thu Jan 14 21:47:13 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916581, encodeId=da1d9165818d, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Thu Jan 14 17:21:22 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916508, encodeId=01aa916508da, content=感谢梅斯医学分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201221/137a6965d29349108c0e34d1034c142d/7d4214f027494937a9ccbccf0d523684.jpg, createdBy=84b02217108, createdName=孤舟蓑笠一老翁, createdTime=Thu Jan 14 14:08:42 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028999, encodeId=14bc1028999e1, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Thu Jan 14 13:29:39 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035551, encodeId=be5f103555199, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jan 14 13:29:39 CST 2021, time=2021-01-14, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1953048, encodeId=d90a1953048cc, content=<a href='/topic/show?id=bafc5283ed3' target=_blank style='color:#2F92EE;'>#恢复期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52837, encryptionId=bafc5283ed3, topicName=恢复期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Fri Apr 09 02:29:39 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667234, encodeId=62c1166e2343e, content=<a href='/topic/show?id=ea04891988c' target=_blank style='color:#2F92EE;'>#血浆治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89198, encryptionId=ea04891988c, topicName=血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150026134820, createdName=jianjun75, createdTime=Sun Jan 31 13:29:39 CST 2021, time=2021-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725196, encodeId=b3d81e2519629, content=<a href='/topic/show?id=58476021257' target=_blank style='color:#2F92EE;'>#曙光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60212, encryptionId=58476021257, topicName=曙光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=180c33737541, createdName=yangpeizhi, createdTime=Mon Jul 19 03:29:39 CST 2021, time=2021-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587298, encodeId=0586158e298ef, content=<a href='/topic/show?id=a6785283909' target=_blank style='color:#2F92EE;'>#恢复期血浆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52839, encryptionId=a6785283909, topicName=恢复期血浆)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f73917462216, createdName=doctorzheng, createdTime=Sat Jan 16 01:29:39 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916645, encodeId=aae5916645e4, content=<a href='/topic/show?id=d5161040529e' target=_blank style='color:#2F92EE;'>#恢复期血浆治疗#</a>又有用了!看来有没有作用,主要看血浆中的抗体多与少!, beContent=null, objectType=article, channel=null, level=null, likeNumber=206, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104052, encryptionId=d5161040529e, topicName=恢复期血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily, createdTime=Thu Jan 14 21:47:13 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916581, encodeId=da1d9165818d, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Thu Jan 14 17:21:22 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916508, encodeId=01aa916508da, content=感谢梅斯医学分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201221/137a6965d29349108c0e34d1034c142d/7d4214f027494937a9ccbccf0d523684.jpg, createdBy=84b02217108, createdName=孤舟蓑笠一老翁, createdTime=Thu Jan 14 14:08:42 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028999, encodeId=14bc1028999e1, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Thu Jan 14 13:29:39 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035551, encodeId=be5f103555199, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jan 14 13:29:39 CST 2021, time=2021-01-14, status=1, ipAttribution=)]
    2021-01-14 孤舟蓑笠一老翁

    感谢梅斯医学分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1953048, encodeId=d90a1953048cc, content=<a href='/topic/show?id=bafc5283ed3' target=_blank style='color:#2F92EE;'>#恢复期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52837, encryptionId=bafc5283ed3, topicName=恢复期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Fri Apr 09 02:29:39 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667234, encodeId=62c1166e2343e, content=<a href='/topic/show?id=ea04891988c' target=_blank style='color:#2F92EE;'>#血浆治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89198, encryptionId=ea04891988c, topicName=血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150026134820, createdName=jianjun75, createdTime=Sun Jan 31 13:29:39 CST 2021, time=2021-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725196, encodeId=b3d81e2519629, content=<a href='/topic/show?id=58476021257' target=_blank style='color:#2F92EE;'>#曙光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60212, encryptionId=58476021257, topicName=曙光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=180c33737541, createdName=yangpeizhi, createdTime=Mon Jul 19 03:29:39 CST 2021, time=2021-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587298, encodeId=0586158e298ef, content=<a href='/topic/show?id=a6785283909' target=_blank style='color:#2F92EE;'>#恢复期血浆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52839, encryptionId=a6785283909, topicName=恢复期血浆)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f73917462216, createdName=doctorzheng, createdTime=Sat Jan 16 01:29:39 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916645, encodeId=aae5916645e4, content=<a href='/topic/show?id=d5161040529e' target=_blank style='color:#2F92EE;'>#恢复期血浆治疗#</a>又有用了!看来有没有作用,主要看血浆中的抗体多与少!, beContent=null, objectType=article, channel=null, level=null, likeNumber=206, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104052, encryptionId=d5161040529e, topicName=恢复期血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily, createdTime=Thu Jan 14 21:47:13 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916581, encodeId=da1d9165818d, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Thu Jan 14 17:21:22 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916508, encodeId=01aa916508da, content=感谢梅斯医学分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201221/137a6965d29349108c0e34d1034c142d/7d4214f027494937a9ccbccf0d523684.jpg, createdBy=84b02217108, createdName=孤舟蓑笠一老翁, createdTime=Thu Jan 14 14:08:42 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028999, encodeId=14bc1028999e1, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Thu Jan 14 13:29:39 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035551, encodeId=be5f103555199, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jan 14 13:29:39 CST 2021, time=2021-01-14, status=1, ipAttribution=)]
    2021-01-14 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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    2021-01-14 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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Worldometers世界实时统计数据显示,截至北京时间2021年1月13日7时11分,全球累计确诊新冠肺炎(COVID-19)病例超过9194万例,新增622,056例,达到91,947,188例

2021年1月14日全球新冠肺炎(COVID-19)疫情简报,确诊超9269万,国内60岁以上老年人可接种,口罩拉到下巴处会增加传染风险

Worldometers世界实时统计数据显示,截至北京时间2021年1月14日7时21分,全球累计确诊新冠肺炎(COVID-19)病例超过9269万例,新增687,653例,达到92,691,382例

2021年1月11日全球新冠肺炎(COVID-19)疫情简报,确诊超9065万,新冠在日本又出现新的突变

Worldometers世界实时统计数据显示,截至北京时间2021年1月11日7时31分,全球累计确诊新冠肺炎(COVID-19)病例超过9065万例,新增593,300例,达到90,657,292例

Lancet Respir Med:肾素-血管紧张素系统抑制剂对新冠肺炎患者预后的影响

研究提示肾素-血管紧张素系统(RAS)抑制剂可能会影响新冠肺炎的严重程度。本研究旨在评估持续和停止使用RAS抑制剂(血管紧张素转换酶抑制剂[ACEI]或血管紧张素受体阻滞剂[ARB])是否影响新冠肺炎

2021年1月12日全球新冠肺炎(COVID-19)疫情简报,确诊超9125万,2021年无法实现新冠群体免疫

Worldometers世界实时统计数据显示,截至北京时间2021年1月12日7时11分,全球累计确诊新冠肺炎(COVID-19)病例超过9125万例,新增527,346例,达到91,252,312例

NEJM:候选新冠肺炎疫苗Ad26.cov2-s I-II期临床研究获得成功

Ad26.COV2.S表现出良好的安全性及免疫原性,其新冠肺炎预防效果需进一步的验证

拓展阅读

NEJM:新冠患者的恢复期血浆——被高估的抗体治疗

2019年末,由SARS-CoV-2病毒引起的新型冠状肺炎Covid-19引发了全球大流行,并致使数百万人被感染。而到目前为止,只有两种药物在进行的大型随机对照试验中显示出了一定程度的临床疗效。一是瑞