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JAHA：肠道菌群代谢物TMAO与心血管死亡风险相关

2020-05-06 MedSci原创 MedSci原创

心血管肠道菌群心血管死亡风险
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三甲胺N-氧化物（TMAO）可能具有血栓的特性。本研究的目的旨在评估TMAO四分位数与主要心血管不良事件（MACE）的相关性，以及TMAO对替卡格雷疗效的影响。

三甲胺N-氧化物（TMAO）可能具有血栓的特性。本研究的目的旨在评估TMAO四分位数与主要心血管不良事件（MACE）的相关性，以及TMAO对替卡格雷疗效的影响。

PEGASUS‐TIMI 54临床研究将既往有心梗的患者随机分成替卡格雷组和安慰剂组（平均随访时间是33个月），并对597名患者和1206名匹配的对照进行了血浆TMAO水平的检测，分析结果发现，更高的TMAO水平与MACE风险呈相关性（P=0.015）。心血管死亡和卒中是导致这种相关性的主要原因。另外，替卡格雷对MACE的降低作用在各TMAO四分位数是一致的。

研究结果显示，在既往心肌梗死患者中，较高的TMAO水平与心血管死亡和卒中相关，但与复发性心肌梗死无关。

原始出处：

Baris G et al.Gut Microbiota‐Dependent Trimethylamine N‐oxide and Cardiovascular Outcomes in Patients With Prior Myocardial Infarction: A Nested Case Control Study From the PEGASUS‐TIMI 54 Trial.JAHA.2020 May.

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    2020-09-28 旅苦化文_216

    #代谢物#

    0

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    2020-05-11 guicaiwei

    好

    0

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    2020-05-08 quxin068

    #死亡风险#

    0

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    2020-05-08 一叶知秋

    #AHA#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1659994, encodeId=fd7f1659994a4, content=<a href='/topic/show?id=24e82545262' target=_blank style='color:#2F92EE;'>#代谢物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25452, encryptionId=24e82545262, topicName=代谢物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c1225086772, createdName=旅苦化文_216, createdTime=Mon Sep 28 06:55:13 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=382726, encodeId=59f5382e267e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/BHHqJOYCGO2Qnoy0HvW6a8484LMTViaaTLQricqaDrrg5shY907vventGeHZZgj5mlobGntCxX1JqYBgoEhLePCw/132, createdBy=a4312343135, createdName=guicaiwei, createdTime=Mon May 11 21:02:54 CST 2020, time=2020-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255975, encodeId=42a112559e517, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268268, encodeId=e1aa126826886, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392394, encodeId=3cb313923946c, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460360, encodeId=b75214603607f, content=<a href='/topic/show?id=96571e54928' target=_blank style='color:#2F92EE;'>#TMAO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17549, encryptionId=96571e54928, topicName=TMAO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0e56300497, createdName=JR19860221, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554214, encodeId=c706155421425, content=<a href='/topic/show?id=ab025182080' target=_blank style='color:#2F92EE;'>#心血管死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51820, encryptionId=ab025182080, topicName=心血管死亡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0fb814514579, createdName=huperzia, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629875, encodeId=868b16298e5fa, content=<a href='/topic/show?id=a913518225e' target=_blank style='color:#2F92EE;'>#心血管死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51822, encryptionId=a913518225e, topicName=心血管死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e76421361831, createdName=baoya, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=)]
    2020-05-08 1249897bm37(暂无昵称)

    #肠道菌#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1659994, encodeId=fd7f1659994a4, content=<a href='/topic/show?id=24e82545262' target=_blank style='color:#2F92EE;'>#代谢物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25452, encryptionId=24e82545262, topicName=代谢物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c1225086772, createdName=旅苦化文_216, createdTime=Mon Sep 28 06:55:13 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=382726, encodeId=59f5382e267e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/BHHqJOYCGO2Qnoy0HvW6a8484LMTViaaTLQricqaDrrg5shY907vventGeHZZgj5mlobGntCxX1JqYBgoEhLePCw/132, createdBy=a4312343135, createdName=guicaiwei, createdTime=Mon May 11 21:02:54 CST 2020, time=2020-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255975, encodeId=42a112559e517, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268268, encodeId=e1aa126826886, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392394, encodeId=3cb313923946c, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460360, encodeId=b75214603607f, content=<a href='/topic/show?id=96571e54928' target=_blank style='color:#2F92EE;'>#TMAO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17549, encryptionId=96571e54928, topicName=TMAO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0e56300497, createdName=JR19860221, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554214, encodeId=c706155421425, content=<a href='/topic/show?id=ab025182080' target=_blank style='color:#2F92EE;'>#心血管死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51820, encryptionId=ab025182080, topicName=心血管死亡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0fb814514579, createdName=huperzia, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629875, encodeId=868b16298e5fa, content=<a href='/topic/show?id=a913518225e' target=_blank style='color:#2F92EE;'>#心血管死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51822, encryptionId=a913518225e, topicName=心血管死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e76421361831, createdName=baoya, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=)]
    2020-05-08 JR19860221

    #TMAO#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1659994, encodeId=fd7f1659994a4, content=<a href='/topic/show?id=24e82545262' target=_blank style='color:#2F92EE;'>#代谢物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25452, encryptionId=24e82545262, topicName=代谢物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c1225086772, createdName=旅苦化文_216, createdTime=Mon Sep 28 06:55:13 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=382726, encodeId=59f5382e267e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/BHHqJOYCGO2Qnoy0HvW6a8484LMTViaaTLQricqaDrrg5shY907vventGeHZZgj5mlobGntCxX1JqYBgoEhLePCw/132, createdBy=a4312343135, createdName=guicaiwei, createdTime=Mon May 11 21:02:54 CST 2020, time=2020-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255975, encodeId=42a112559e517, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268268, encodeId=e1aa126826886, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392394, encodeId=3cb313923946c, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460360, encodeId=b75214603607f, content=<a href='/topic/show?id=96571e54928' target=_blank style='color:#2F92EE;'>#TMAO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17549, encryptionId=96571e54928, topicName=TMAO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0e56300497, createdName=JR19860221, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554214, encodeId=c706155421425, content=<a href='/topic/show?id=ab025182080' target=_blank style='color:#2F92EE;'>#心血管死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51820, encryptionId=ab025182080, topicName=心血管死亡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0fb814514579, createdName=huperzia, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629875, encodeId=868b16298e5fa, content=<a href='/topic/show?id=a913518225e' target=_blank style='color:#2F92EE;'>#心血管死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51822, encryptionId=a913518225e, topicName=心血管死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e76421361831, createdName=baoya, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=)]
    2020-05-08 huperzia

    #心血管死亡#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1659994, encodeId=fd7f1659994a4, content=<a href='/topic/show?id=24e82545262' target=_blank style='color:#2F92EE;'>#代谢物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25452, encryptionId=24e82545262, topicName=代谢物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c1225086772, createdName=旅苦化文_216, createdTime=Mon Sep 28 06:55:13 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=382726, encodeId=59f5382e267e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/BHHqJOYCGO2Qnoy0HvW6a8484LMTViaaTLQricqaDrrg5shY907vventGeHZZgj5mlobGntCxX1JqYBgoEhLePCw/132, createdBy=a4312343135, createdName=guicaiwei, createdTime=Mon May 11 21:02:54 CST 2020, time=2020-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255975, encodeId=42a112559e517, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268268, encodeId=e1aa126826886, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392394, encodeId=3cb313923946c, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460360, encodeId=b75214603607f, content=<a href='/topic/show?id=96571e54928' target=_blank style='color:#2F92EE;'>#TMAO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17549, encryptionId=96571e54928, topicName=TMAO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0e56300497, createdName=JR19860221, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554214, encodeId=c706155421425, content=<a href='/topic/show?id=ab025182080' target=_blank style='color:#2F92EE;'>#心血管死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51820, encryptionId=ab025182080, topicName=心血管死亡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0fb814514579, createdName=huperzia, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629875, encodeId=868b16298e5fa, content=<a href='/topic/show?id=a913518225e' target=_blank style='color:#2F92EE;'>#心血管死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51822, encryptionId=a913518225e, topicName=心血管死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e76421361831, createdName=baoya, createdTime=Fri May 08 05:55:13 CST 2020, time=2020-05-08, status=1, ipAttribution=)]
    2020-05-08 baoya

    #心血管死亡风险#

    0

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