Diabetologia:做2型糖尿病筛查会获益更多?

2018-01-30 MedSci MedSci原创

近日,国际杂志 《Diabetologia》上在线发表一项关于做2型糖尿病筛查是否会获益更多的研究。研究人员的目的是调查在筛查中发现的糖尿病病例是否比在临床检测到的病例中有更好的健康结局。 Västerbotten干预项目是瑞典Västerbotten县的一个以社区和个人为基础的公共卫生项目。研究人员邀请居民参加临床检查,包括30岁,40岁,50岁和60岁的OGTT筛查糖尿病(符合筛查条件的

近日,国际杂志 《Diabetologia》上在线发表一项关于做2糖尿病筛查是否会获益更多的研究。研究人员的目的是调查在筛查中发现的糖尿病病例是否比在临床检测到的病例中有更好的健康结局。

Västerbotten干预项目是瑞典Västerbotten县的一个以社区和个人为基础的公共卫生项目。研究人员邀请居民参加临床检查,包括30岁,40岁,50岁和60岁的OGTT筛查糖尿病(符合筛查条件的个人,n=142,037)。在1992年至2013年期间,研究人员使用注册数据确定了1024个筛查的病例和8642个临床检测到的糖尿病病例。临床检测到的个人是先前筛选的参与者(n= 4506)或没有参与筛选的人(非参与者,n = 4136)。从筛选日到随访结束,移植,死亡或心血管疾病(CVD),肾脏疾病或视网膜病变事件结束之后,对患有糖尿病的个体进行研究,并使用日历时间,检测年龄,发现年份,性别和社会经济状况校正的Cox比例风险回归进行比较。

研究发现,与临床检测的个体相比,筛查个体糖尿病诊断的平均年龄的个体低4.6岁。总的来说,临床上检测到的患者的健康状况比筛检出的患者更差(全因死亡的HR2.07 [95CI 1.63,2.62])。与筛查的研究个体相比,非参与筛查者的临床检测个体的全因死亡率(HR 2.31 [95CI 1.82,2.94])高于之前参加过筛查参与者(HR 1.70 [ 95CI 1.32,2.18])。估计CVD,肾病和视网膜病的遵循类似模式。

在全因死亡率,心血管疾病,肾脏疾病和视网膜病方面,筛查的糖尿病患者似乎因为诊断较早,比那些临床检测的患者结局较好。这些关联中有多少可以通过早期治疗来解释,仍需要进一步调查。

原始出处:

Adina L. Feldman, Simon J. Griffin, Eva Fhärmet al. Screening for type 2 diabetes: do screen-detected cases fare better?

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createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Jan 31 07:22:44 CST 2018, time=2018-01-31, status=1, ipAttribution=)]
    2018-02-02 chunjianf

    学习了.谢谢分享

    0

  5. 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createdBy=18741984753, createdName=smartxiuxiu, createdTime=Wed Jan 31 07:56:23 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283758, encodeId=e282283e5861, content=还是要提高三率, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Wed Jan 31 07:25:19 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283753, encodeId=4a1b283e5351, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Jan 31 07:22:44 CST 2018, time=2018-01-31, status=1, ipAttribution=)]
    2018-02-01 flysky120

    学习一下知识了

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Jan 31 14:53:08 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283781, encodeId=9381283e813f, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Jan 31 08:40:41 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283769, encodeId=c6e5283e69b5, content=支持, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, 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createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Jan 31 07:22:44 CST 2018, time=2018-01-31, status=1, ipAttribution=)]
    2018-01-31 sunfeifeiyang

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Jan 31 07:22:44 CST 2018, time=2018-01-31, status=1, ipAttribution=)]
    2018-01-31 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Jan 31 07:22:44 CST 2018, time=2018-01-31, status=1, ipAttribution=)]
    2018-01-31 smartxiuxiu

    支持

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Jan 31 07:22:44 CST 2018, time=2018-01-31, status=1, ipAttribution=)]
    2018-01-31 lou.minghong

    还是要提高三率

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Jan 31 07:22:44 CST 2018, time=2018-01-31, status=1, ipAttribution=)]
    2018-01-31 榄枷檬

    谢谢分享

    0

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