Diabetes Care:早期婴儿饮食和胰岛自身免疫!

2018-01-18 xing.T MedSci原创

由此可见,辅食中加入面筋的时机IA之间的相关性值得进一步研究。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在评估母乳喂养时间、补充辅食时机与胰岛自身免疫(IA)风险之间的相关性。

TEDDY研究前瞻性地随访了美国、芬兰、德国和瑞典的8676例遗传风险增加的1型糖尿病(T1D)患者。这项研究包含了7563名至少随访9个月的儿童。从出生到评价IA时每3个月进行血液样本收集,IA定义为持续性的、胰岛素自身抗体(IAAs)、谷氨酸脱羧酶或胰岛抗原-2阳性。研究人员使用Cox回归模型评估了饮食与IA风险之间的相关性,调整了国家、糖尿病家族史、HLA基因型、性别和早期益生菌暴露。此外,研究人员评估了残差和对数秩统计量以确定饮食暴露的年龄临界点。

辅食中较晚的加入面筋与任何IA和IAA风险增加有关。辅食中加入面筋的时间每晚一个月的风险比(HR)分别为1.05(95%可信区间为1.01-1.10;P=0.02)和1.08(95%可信区间为1-1.16;P=0.04)。残差分析表明辅食中加入面筋的时间可分为小于4, 4-9个月、大于9个月。IA风险与在小于4个月龄期间辅食中加入面筋之间的相关性较低(HR为0.68,95%可信区间为0.47-0.99),相比于在4个月-9个月期间辅食中加入面筋相比,超过9个月龄辅食中加入面筋患儿的IA风险较高(HR为1.57,95%可信区间为1.07-2.31)。

由此可见,辅食中加入面筋的时机IA之间的相关性值得进一步研究。

原始出处:

Ulla Uusitalo, et al. Early Infant Diet and Islet Autoimmunity in the TEDDY Study. Diabetes Care 2018.https://doi.org/10.2337/dc17-1983

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    2018-06-07 baoya
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    2018-01-29 haige

    学习了!谢谢分享!

    0

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    2018-01-18 137****9095

    henhao

    0

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    2018-01-18 惠映实验室

    学习了.谢谢分享.

    0