Lancet Neurology:Satralizumab治疗视神经脊髓炎谱系障碍(NMOSD),安全有效

2020-04-26 Allan MedSci原创

Chugai制药株式会社近日宣布,Satralizumab的全球III期SAkuraStar研究(NCT02073279)的结果已于4月22日发布于《Lancet Neurology》。

Chugai制药株式会社近日宣布,Satralizumab的全球III期SAkuraStar研究(NCT02073279)的结果已于4月22日发布于《Lancet Neurology》。Satralizumab是一种抗IL6受体的人源化抗体,正在开发用于治疗视神经脊髓炎谱系障碍(NMOSD)。III期研究检查了Satralizumab单药治疗NMOSD的有效性和安全性。NMOSD是一种罕见的中枢神经系统自身免疫性疾病,患者的免疫系统侵袭视神经和脊髓,导致视力丧失和瘫痪。

Chugai总裁兼首席运营官Osamu Okuda博士说:“Satralizumab单药的长期疗效强调了IL-6抑制在治疗NMOSD中的重要作用”。

在SAkuraStar研究中,Satralizumab显著降低了总人群的复发风险。重要的是,接受Satralizumab治疗的患者在第48、96和144周时无复发,无复发患者比例分别为76.1%、72.1%和62.8%,而安慰剂组无复发患者比例分别为61.9%、51.2%和34.1%。Satralizumab和安慰剂治疗组之间的严重不良事件比例相似,Satralizumab组中最常见的不良事件是尿路感染和上呼吸道感染。

 

原始出处:

https://www.firstwordpharma.com/node/1718291

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GetPortalCommentsPageByObjectIdResponse(id=1949510, encodeId=b83019495103e, content=<a href='/topic/show?id=f237e452185' target=_blank style='color:#2F92EE;'>#神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74521, encryptionId=f237e452185, topicName=神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Mon Oct 05 15:23:49 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1674268, encodeId=325416e426871, content=<a href='/topic/show?id=589615914ee' target=_blank style='color:#2F92EE;'>#Satralizumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15914, encryptionId=589615914ee, topicName=Satralizumab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ef626951425, createdName=zblhy, createdTime=Wed Apr 29 23:23:49 CST 2020, time=2020-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667000, encodeId=a4e0166e00006, content=<a href='/topic/show?id=5fda90e061e' target=_blank style='color:#2F92EE;'>#视神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90706, encryptionId=5fda90e061e, topicName=视神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=14db26078051, createdName=gj0740, createdTime=Sat Feb 20 20:23:49 CST 2021, time=2021-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830604, encodeId=d1401830604ac, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Apr 05 17:23:49 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657319, encodeId=075a165e3194b, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Wed Jun 24 00:23:49 CST 2020, time=2020-06-24, status=1, ipAttribution=)]
    2020-09-18 xlysu
  5. [GetPortalCommentsPageByObjectIdResponse(id=2001035, encodeId=18ae20010350a, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Oct 03 05:23:49 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947493, encodeId=2108194e493a3, content=<a href='/topic/show?id=c11f29e67e' target=_blank style='color:#2F92EE;'>#ATRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2976, encryptionId=c11f29e67e, topicName=ATRA)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Sun Jun 07 19:23:49 CST 2020, time=2020-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1678190, encodeId=86a616e81905c, content=<a href='/topic/show?id=7f2c1e736f1' target=_blank style='color:#2F92EE;'>#TRALI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17736, encryptionId=7f2c1e736f1, topicName=TRALI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Jul 23 10:23:49 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650455, encodeId=244b1650455c0, content=<a href='/topic/show?id=b14384624a3' target=_blank 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topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Apr 05 17:23:49 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657319, encodeId=075a165e3194b, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Wed Jun 24 00:23:49 CST 2020, time=2020-06-24, status=1, ipAttribution=)]
    2020-05-05 snf701207
  6. 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  7. 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  8. 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    2021-02-20 gj0740
  9. 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    2021-04-05 howi
  10. 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topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Apr 05 17:23:49 CST 2021, time=2021-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657319, encodeId=075a165e3194b, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Wed Jun 24 00:23:49 CST 2020, time=2020-06-24, status=1, ipAttribution=)]
    2020-06-24 bsmagic9140

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2023年度巨献:中国罕见病领域十大医学研究出炉

2023年梅斯年终巨献:中国重磅级医学研究成果解读!

STTT:华中科技大学王伟团队证明CAR-T细胞疗法能够安全有效治疗复发或难治性视神经脊髓炎谱系障碍

这项首次在人体中进行的研究初步证明了CAR-BCMA T细胞CT103A可以作为复发或难治性AQP4-IgG血清阳性NMOSD患者的一种安全且潜在的单一疗法,并值得在更广泛的应用中进行进一步评估。

JNNP:髓鞘少突胶质细胞糖蛋白抗体相关疾病,视神经脊髓炎谱系障碍中脑干和小脑受累对比

髓鞘少突胶质细胞糖蛋白(MOG)抗体相关疾病(MOGAD)是一种中枢神经系统(CNS)炎症性脱髓鞘疾病,定义为MOG IgG血清阳性,不同于多发性硬化症(MS)和水通道蛋白-4-IgG血清阳性的视神经

Lancet Neurology:Satralizumab单药治疗视神经脊髓炎谱系障碍的安全性和有效性:一项随机、双盲、多中心、安慰剂对照的3期试验

视神经脊髓炎谱系障碍(NMOSD)是一种自身免疫性神经疾病,全球发病率为估计为1.82/10万人。这种疾病的特点是视神经、脊髓、脑干和大脑的炎症性病变,可能会导致严重的运动和感觉障碍、膀胱功能障碍等。

罗氏的白细胞介素6受体单抗Satralizumab治疗视神经脊髓炎谱系障碍的临床试验成功

罗氏(Roche)宣布了其SAkuraSky研究的数据,该研究中评估了靶向白细胞介素6(IL-6)受体单抗satralizumab(SA237)用于治疗视神经脊髓炎谱系障碍(NMOSD)的安全性和疗效。NMOSD是一种中枢神经系统炎症。

NEJM:Eculizumab治疗AQP4-IgG阳性视神经脊髓炎谱系障碍

在AQP4-IgG阳性的NMOSD患者中,接受Eculizumab治疗可显著降低患者的复发风险