Biomaterials:研制出具有光热促成骨作用的复合生物材料

2019-02-20 佚名 深圳先进技术研究院

近日,中国科学院深圳先进技术研究院副研究员童丽萍、研究员王怀雨与香港城市大学教授朱剑豪等合作,成功研制出一种具有光热响应的智能生物材料,该材料可用于促进骨缺损部位的再生修复。相关论文以Near-Infrared Light Control of Bone Regeneration with Biodegradable Photothermal Osteoimplant 为题发表在生物材料领域期刊B

近日,中国科学院深圳先进技术研究院副研究员童丽萍、研究员王怀雨与香港城市大学教授朱剑豪等合作,成功研制出一种具有光热响应的智能生物材料,该材料可用于促进骨缺损部位的再生修复。相关论文以Near-Infrared Light Control of Bone Regeneration with Biodegradable Photothermal Osteoimplant 为题发表在生物材料领域期刊Biomaterials上。

热疗是一种对正常组织损伤较小的传统疗法,自古代以来就被广泛地用于治疗诸多慢性疾病。然而常规的热疗方法受限于外部直接加热传递效率低下的问题,治疗效果较为有限。近年来随着纳米技术的快速发展,纳米光热治疗已经成为肿瘤治疗领域的一个研究热点,具有适用范围广、选择性强、操作简便等显着优点。

受肿瘤光热治疗研究的启发,团队基于前期与喻学锋课题组在黑磷基生物材料方面的研究合作,将黑磷纳米片与可生物降解的医用高分子PLGA相复合,制备出一种具有光热响应作用的新型骨科植入材料。此种新型的复合生物材料仅需要添加0.2%的黑磷纳米片,就能够在肌肉组织覆盖下具有较高的光热转化效果,甚至在植入大鼠骨缺损部位后仍对近红外光照具有很强的光热响应。研究团队进一步研究发现,40~42℃范围的局部光热刺激就能够显着促进骨缺损部位的组织再生,而黑磷纳米片的添加还能够调控高分子基材的降解,因此可用作一种理想的骨科植入材料。在此项工作中,研发团队还深入探讨了光热促成骨的分子生物学机制,为骨科植入材料的功能设计提供了一条全新思路。

该项研究得到国家自然科学基金、中科院青促会、深圳市孔雀团队、中科院STS区域重点项目等的资助。

原始出处:

LipingTong,et al.Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant.Biomaterials.Volume 193, February 2019, Pages 1-11

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    2019-12-25 sunylz
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    2019-02-22 zhaojie88
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    2019-02-21 医者仁心5538

    学习了

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